Clinical trials: sponsored by Zhejiang University
Critical Illness
Bedside Air Quality in ICU and Clinical Outcome
There is a close relationship between air pollution and cardiovascular disease. Small particulate matter and inhalable particulate matter in the air are the main components of air pollution, which can enter the respiratory system…
- Trial name
- NCT06201754
- Testing
- Measure air quality
- Where
- 3 sites in China
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pheochromocytoma
18F-mFBG PET Imaging in the Evaluation of Pheochromocytoma
The aim of this study is to evaluate the diagnostic performance and tumor burden of 18F-metafluorobenzylguanidine (18F-MFBG) positron emission tomography (PET) in patients with pheochromocytoma.
- Trial name
- NCT06813742
- Testing
- 18F-MFBG
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
CNI-resistant Steriod Resistant Nephrotic Syndrome, CNI-intolerent
Blinatumomab for CNI-Resistant/Intolerant SRNS in Children
This exploratory clinical trial aims to evaluate the efficacy and safety of Blinatumomab in treating children with calcineurin inhibitor (CNI)-resistant or multidrug-resistant steroid-resistant nephrotic syndrome (SRNS).
- Conditions
- CNI-resistant Steriod Resistant Nephrotic Syndrome, CNI-intolerent, Steriod Resistant Nephrotic Syndrome, Multidrug Resistant Nephrotic Syndrome
- Trial name
- NCT06607991
- Testing
- Blinatumomab Treatment
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Immune Evasion, Tumor, Pancreas Cancer
Construction and Clinical Application of the Immune Map of Pancreatic Cancer Evolution
The intricate interplay between systemic immunity and tumors profoundly influences not only the onset and progression of tumors but also serves as a crucial window into understanding tumor evolution and treatment status.
- Trial name
- NCT07034339
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Leukemia, Relapse
Effectiveness and Safety of Blinatumomab and Donor Lymphocyte Infusion in Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation for High-risk Ph Negative B Cell Acute Lymphoblastic Leukemia
A single-arm trial to evaluate the effectiveness and safety of Blinatumomab and Donor Lymphocyte Infusion in maintenance therapy after allogeneic hematopoietic stem cell transplantation for high-risk Ph negative B cell acute…
- Trial name
- NCT07105579
- Testing
- BITE and DLI
- Where
- China
- Volunteers
- 31 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Advanced Solid Tumors
Study of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumors.
A Phase I Study of Dose Escalation and Dose Expansion To Evaluate the Safety、Tolerability、Pharmacokinetics and Preliminary Efficacy of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumor.
- Trial name
- NCT04778839
- Testing
- Paclitaxel Micelles for Injection, Paclitaxel injection
- Where
- China
- Volunteers
- 98 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Liver Transplant
Outcomes and Risk Factors for Liver Transplantation Using Significant Fibrotic Grafts
This is a multi-center study to investigate the impact of fibrotic liver greafts in liver transplant recipient.
- Trial name
- NCT07101718
- Testing
- No intervention
- Where
- China
- Volunteers
- 25,419 people
- Sponsor
- Zhejiang University
Sleep Deprivation, Aging
The Peripheral Blood Multi-Omics Study on Sleep Loss
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related…
- Conditions
- Sleep Deprivation, Aging, Alzheimer Disease, Healthy Lifestyle
- Trial name
- NCT06492109
- Testing
- Sleep manipulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Primary Central Nervous System Hodgkin Lymphoma
Orelabrutinib, Sintilimab and Temozolomide in Relapsed or Refractory Central Nervous System Lymphoma
This phase II trial is evaluating the efficacy and side effect of orelabrutinib, sintilimab and temozolomide as possible treatments for relapsed or refractory central nervous system lymphoma.
- Trial name
- NCT04961515
- Testing
- Orelabrutinib, Sintilimab, Temozolomide (TMZ)
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Relapsed/Refractory Primary Central Nervous System Lymphoma
A Study of Selinexor in Combination With Temozolomide and Anti-PD-1 Antibody in Patients With Relapsed/Refractory Primary Central Nervous System Lymphoma
This study is a prospective, single-arm, open label, Phase Ib/II clinical study to evaluate the safety and efficacy of selinexor in combination with temozolomide and anti-PD-1 monoclonal antibody in patients with…
- Trial name
- NCT06556199
- Testing
- Selinexor, Temozolomide, Anti-PD-1 monoclonal antibody
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Breast Fibroadenoma
Exploring a Breast Cancer Early Screening Model Based on cfDNA
The goal of this observational study is to use cfDNA multi-omics technology to explore a new breast cancer early detection model to improve the accuracy of early diagnosis in breast cancer patients.
- Conditions
- Breast Cancer, Breast Fibroadenoma, Breast Hypoplasia
- Trial name
- NCT06016790
- Testing
- cfDNA sequencing
- Where
- 8 sites in China
- Volunteers
- 839 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Cancer, Advanced Adenoma
China Colorectal Cancer Screening Trial 2 (C-Cost2)
Colorectal cancer (CRC) is one of the most common malignancies in China. Currently, its incidence rate is increasing at a rate of 4% per year, exceeding the global annual average growth rate.
- Trial name
- NCT07090304
- Testing
- FIT, FIT-sDNA
- Volunteers
- 7,504 people
- Sponsor
- Zhejiang University
Pulmonary Arterial Hypertension (PAH)
Comparison of Sequential to Initial Combination Therapy in PAH
This is a multicenter, randomized, controlled, double-blind, and non-inferiority clinical trial to compare the efficacy of sequential to initial combination therapy in patients with pulmonary arterial hypertension (PAH).
- Trial name
- ORIENTATION (NCT06968962)
- Testing
- Tadalafil, Ambrisentan, Ambrisentan mimic
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cognitive Impairment, Dementia
Smartphone Multimodal Health Intervention for Neurological Enhancement (SHINE)
This randomized controlled trial will enroll individuals aged ≥ 40 years without dementia who are at high risk for stroke, collecting multi-modal MRI imaging, serum, and fecal samples to investigate the effects of a…
- Conditions
- Cognitive Impairment, Dementia, Artificial Intelligence (AI), Stroke
- Trial name
- NCT07092371
- Testing
- Digital Multimodal Intervention
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hereditary Ataxia
Hereditary Ataxia Research on Multi-Omics and Neuroclinical Insights in the Yangtze Delta
The goal of this observational study is to explore the clinical and genetic characteristics, multi-omics profiles, disease mechanisms, biomarkers, and potential therapeutic targets of hereditary ataxia (HA) in patients diagnosed…
- Trial name
- HARMONY (NCT07092358)
- Testing
- None of intervention
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Edentulous Alveolar Ridge In Mandible
Clinical Effects of Keratinized Mucosa Augmentation Around Dental Implant With Free Gingival Graft in Different Surgical Timing at Mandibular Posterior Sites
This study aims to compare clinical outcomes and tissue stability at implant sites in the mandibular posterior region with insufficient buccal keratinized gingiva.
- Trial name
- NCT07088172
- Testing
- free gingival grafts during the second stage of implant surgery, free gingival grafts prior to the implantaion
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Ulcerative Colitis
Study of the Effect of Vedolizumab on Intestinal Microecological Changes and Its Efficacy in the Treatment of Ulcerative Colitis
Inflammatory bowel disease is a group of chronic, non-specific inflammatory diseases of the intestinal tract whose etiology has not yet been fully elucidated, including ulcerative colitis and Crohn's disease.
- Trial name
- NCT05481619
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Headache Disorders, Primary, Headache Disorders, Secondary
China Headache and Vertigo Registry Study
In the Chinese Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular…
- Conditions
- Headache Disorders, Primary, Headache Disorders, Secondary, Migraine, Tension-Type Headache
- Trial name
- CHRS (NCT04939922)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Migraine, Transcranial Magnetic Stimulation Repetitive
Individualized Location-based rTMS for Migraine Treatment: A Multicenter Clinical Study
For migraine patients experiencing at least four attack days per month and undergoing transcranial magnetic stimulation (TMS) treatment, a randomized, double-blind controlled trial is conducted, dividing participants into a…
- Trial name
- individua rTMS (NCT07086274)
- Testing
- Individualized location-based Repetitive Transcranial Magnetic Stimulation, Traditional location-based Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
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