Clinical trials: sponsored by Zhejiang University
Advanced Solid Tumor
A Dose Escalation and Dose Expansion Clinical Study of STI-7349 in Subjects With Advanced Solid Tumors
This is a first-in-human, Phase Ⅰ, open-label, 2-period dose escalation and expansion study of STI-7349 administered intravenously to subjects with advanced solid tumors: Period I is divided into two parts: Dose escalation for…
- Trial name
- NCT05978102
- Testing
- STI-7349, Pembrolizumab, Standard treatment（SoC）
- Where
- China
- Volunteers
- 183 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Acute Necrotizing Pancreatitis, Portal Hypertension
A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH).
- Trial name
- NCT07080697
- Testing
- Splenectomy, Control
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang University
Dup15q Syndrome, Autism Spectrum Disorder
Investigating the Therapeutic Efficacy of All-trans Retinoic Acid in Autism Spectrum Disorder Patients With 15q11-13 Duplication Syndrome
Autism spectrum disorder (ASD) , hereafter referred to as autism, is a group of neurodevelopmental disorders caused by genetic and environmental factors.
- Conditions
- Dup15q Syndrome, Autism Spectrum Disorder, Therapy, All-trans Retinoic Acid
- Trial name
- NCT07079696
- Testing
- ATRA
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Implant Failure, Bone Augmentation
Effect of Bone Augmentation Simultaneous to Implant Removal on the Prognosis of Reimplantation at the Same Site
The aim of this study was to investigate the effect of bone augmentation simultaneous to implant removal on the prognosis of reimplantation at the same sites, providing recommendations for management strategies after failed…
- Conditions
- Implant Failure, Bone Augmentation, Prognosis
- Trial name
- NCT07078890
- Testing
- bone augmentation simultaneous to implant removal
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Congenital Ptosis
Research on Precision Diagnosis and Treatment Decision of Common Eye Diseases Based on Artificial Intelligence
The goal of this observational study is to investigate the clinical features of congenital ptosis in children by analyzing eyelid movement captured through smartphone videos.
- Trial name
- NCT07078552
- Testing
- ptosis
- Where
- China
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
NENS
NALIRIFOX as Second-Line Chemotherapy in Extrapulmonary High-grade Neuroendocrine Neoplasms: a Prospective, Single-center, Single-arm Trial
High-grade neuroendocrine neoplasms (NENs) comprise both well-differentiated grade 3 neuroendocrine tumors (G3 NETs) and poorly differentiated neuroendocrine carcinomas (NECs).
- Trial name
- NCT07077551
- Testing
- NALIRIFOX
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neuroendocrine Neoplasms (Tumours)
The Efficacy of TROP2-ADC in Advanced Extrapulmonary High-Grade Neuroendocrine Neoplasms Failure of Standard Therapy
The response rate to second-line or later therapies for extrapulmonary high-grade neuroendocrine neoplasms (NENs) remains low, with no established standard treatment regimen.
- Trial name
- SKB264-II-NEN (NCT07077564)
- Testing
- Sac-TMT
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07051980
- Testing
- Supraglottic Oxygen Delivery via an Endotracheal Tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Cervical Cancer, Endometrial Cancer
A Cohort Study of Uterine Malignancies
The purposes of current study were to explore the relationship between cervical cancer/endometrial cancer and demographic information, behavior and life style, pregnancy-related factors, and disease history, and to study the…
- Trial name
- NCT05635123
- Testing
- No intervention
- Where
- China
- Volunteers
- 6,200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Ovarian Cancer
Study on the Dynamic Changes of Metabolic Biomarkers and Their Prognostic Relationship in Ovarian Cancer
Ovarian cancer is a highly lethal gynecological malignancy, often diagnosed at an advanced stage, with high rates of recurrence within 1-2 years after frontline treatment.
- Trial name
- NCT06019923
- Testing
- No intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma
Clinical Follow-up Study of CD19 CAR-T Expressing IL7 and CCL19 for Relapsed or Refractory B Cell Lymphoma
This study is designed to monitor all patients exposed to CD19 CAR-T expressing IL7 and CCL19 for 5 years following infusion, to assess their long-term efficacy, including the CAR-vector persistence, the normal immunity…
- Conditions
- Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, Transformed Follicular Lymphoma, Primary Mediastinal Large B-cell Lymphoma
- Trial name
- NCT04833504
- Testing
- CD19 CAR-T Expressing IL7 and CCL19
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
HPV Vaccination Intention Among Male College Students
Message Framing in HPV Vaccination Decision
The goal of this clinical trial is to determine if different risk communication strategies can increase the intention to receive the HPV vaccine among male college students in China.
- Trial name
- NCT07068802
- Testing
- Message framing
- Where
- China
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Crohn Disease
A Study on the Impact of Online Positive Psychological Intervention on the Mental Health and Quality of Life of Crohn's Disease Patients
Crohn's disease (CD) is a chronic, nonspecific inflammatory disease that can affect the entire digestive tract. It is difficult to cure and often relapses, causing long-term suffering for patients.
- Trial name
- NCT06939712
- Testing
- Online Positive Psychology Intervention, Routine Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Portal Vein Thrombosis, Portal Hypertension Related to Cirrhosis
Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient
This study aims to evaluate the accuracy and safety of a novel endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement technique in 42 adults with liver cirrhosis and portal vein thrombosis (blood clots in the…
- Trial name
- NCT07062289
- Testing
- endoscopic ultrasound-guided portal pressure gradient
- Volunteers
- 42 people
- Sponsor
- Zhejiang University
Hepatolithiasis, Sphincter of Oddi Dysfunction
Roux-en-Y Hepaticojejunostomy for Hepatolithiasis With Sphincter of Oddi Laxity
Objective: Evaluate the role of Roux-en-Y hepaticojejunostomy (RYHJ) in hepatolithiasis patients with sphincter of Oddi laxity (SOL).
- Trial name
- NCT01459549
- Testing
- Roux-en-Y hepaticojejunostomy
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Zhejiang University
Brain Tumor Adult, Cerebrovascular Disease
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull.
- Trial name
- NCT07049094
- Testing
- scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution, scalp nerve block with 0.50% hydrochloride bupivacaine
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Zhejiang University
Liver Injury
A Prospective Study of ¹⁸F-DFA PET Imaging for the Assessment of Liver Injury
This study is a prospective exploratory clinical study aimed at evaluating the efficacy (sensitivity, specificity) of 18F-DFA PET imaging in assessing liver function damage.
- Trial name
- NCT07050550
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Refractory Generalized Myasthenia Gravis
An Exploratory Clinical Study of GC012F Injection for Refractory gMG
This study is a single-arm, open-label early exploratory clinical trial designed to evaluate the safety, tolerability, and preliminary efficacy of GC012F injection in subjects with refractory GMG.
- Trial name
- gMG (NCT06419166)
- Testing
- GC012F injection
- Where
- China
- Sponsor
- Zhejiang University
Vestibular Migraine
The R-E-V-I-V-A-L Study
Vestibular migraine (VM) is one of the most common vestibular disorders, affecting 1.0% to 2.7% of the general population1, 7% of patients with definite migranous vertigo in dizziness clinics2, as well as 10.3% of VM patients in…
- Trial name
- NCT06992674
- Testing
- Rimegepant
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoxia, Esophageal Cancer
Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastrointestinal Endoscopy for Obese Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy, particularly in obese patients.
- Conditions
- Hypoxia, Esophageal Cancer, Gastric Cancer, Polyp of Colon
- Trial name
- NCT06812403
- Testing
- the COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.