Clinical trials: sponsored by Zhejiang University
Non-Small Cell Lung Cancer
SIB Accelerated Hyperfractionated RT for High-Proliferation NSCLC
This is a prospective, single-arm, single-center phase I/II clinical trial evaluating the safety, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) of simultaneous integrated boost…
- Trial name
- HP-SIB-AHFRT (NCT07823855)
- Testing
- hyperfractionated radiotherapy
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Neoplasms, Colonic Polyp
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial
This study is a multi-center, randomized controlled trial designed to evaluate whether an artificial intelligence (AI) system can assist endoscopists to improve the detection rate of colorectal adenomas and cancers during…
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Colorectal Cancer
- Trial name
- AI-COLOADR (NCT07307547)
- Testing
- AI-Assisted Colonoscopy
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
ST-segment Elevation Myocardial Infarction (STEMI)
Effect and Safety of Fexofenadine Hydrochloride vs Placebo in Patients With Acute Myocardial Infaction: A Randomized Clinical Trial
The purpose of this study was to evaluate the efficacy and safety of fexofenadine hydrochloride on the basis of standard treatment after PCI in STEMI patients.
- Trial name
- FEND-AMI (NCT06548204)
- Testing
- Fexofenadine Hydrochloride
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypertrophic Cardiomyopathy (HCM)
The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction
This study is a prospective interventional cohort study aimed at evaluating the therapeutic efficacy and clinical utility of Mavacamten-a targeted myosin inhibitor specifically developed for obstructive hypertrophic…
- Trial name
- BRAVE-HCM (NCT07103655)
- Testing
- mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Locally Advanced Rectal Cancer (LARC), 5-12cm to Anal Verge
Iparomlimab and Tuvonralimab Combined With Chemotherapy and Bevacizumab as Neoadjuvant Therapy for Locally Advanced Rectal Cancer
This study aims to observe and evaluate the efficacy and safety of Iparomlimab and Tuvonralimab（QL-1706） combined with chemotherapy and bevacizumab ± radiotherapy as neoadjuvant therapy in patients with locally advanced rectal…
- Trial name
- IT-CABLE (NCT07769853)
- Testing
- Iparomlimab and Tuvonralimab（QL-1706）combined with Chemotherapy and Bevacizumab
- Volunteers
- 56 people
- Sponsor
- Zhejiang University
Hypertrophic Cardiomyopathy (HCM)
A Real-World Study on Hypertrophic Cardiomyopathy in Chinese Population
This study is a prospective cohort study aimed at exploring the baseline characteristics and treatment patterns of the Chinese population with hypertrophic cardiomyopathy (HCM) in real-world settings.
- Trial name
- HCM (NCT06775665)
- Testing
- No interventions were applied to the patients.
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Extensive-stage Small Cell Lung Cancer (ES-SCLC), Extensive Stage Lung Small Cell Cancer
Sintilimab Combined With Tafolecimab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer
This is a single arm, multi-center clinical trial. The goal of this clinical trial is to evaluate the efficacy, safety and biomarkers of Tafolecimab combined with Sintilimab and Chemotherapy as first-line treatment for patients…
- Conditions
- Extensive-stage Small Cell Lung Cancer (ES-SCLC), Extensive Stage Lung Small Cell Cancer, Extensive-Stage Small-Cell Lung Cancer, Extensive Disease Small Cell Lung Cancer
- Trial name
- STAR-SCLC (NCT07061535)
- Testing
- Tafolecimab, Sintilimab (approved), Etoposide
- Where
- 5 sites in China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Malignancy
LEAF (Liver Tumor dEtection And classiFication AI)
This study aims to assess the feasibility of leveraging non-contrast CT and artificial intelligence to detect liver cancer in consecutive real-world patients.
- Trial name
- LEAF (NCT06859840)
- Testing
- LEAF(Liver tumor dEtection And classiFication AI)
- Where
- China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Large-Artery Atherosclerosis (Embolus/Thrombosis)
18F-S2P PET Imaging in the Evaluation of Large Artery Atherosclerosis
The aim of this study is to evaluate the lesion detection performance and safety of 18F-S2P positron emission tomography (PET) in patients with large-artery atherosclerosis.
- Trial name
- NCT07815860
- Testing
- 18F-S2P
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Severe Sepsis, Carbapenem Resistant Bacterial Infection
Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients
This prospective observational study is conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from June 1, 2021 to January 1, 2024.
- Trial name
- NCT05413343
- Testing
- Ceftazidime-avibactam
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Lymphoblastic Leukemia, Pediatric
Ph+ ALL in Chinese Children: Diagnosis, Treatment, and Survival
The study aims to conduct a real-world investigation of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in China, assessing their diagnosis, treatment status, survival outcomes, and…
- Trial name
- RWD-Ph+ ALL (NCT07813208)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Solid Tumors
Physician and Patient Preferences for Cell Therapies in Advanced Solid Tumors
Cell therapies - including chimeric antigen receptor T-cell (CAR-T) therapy, tumor-infiltrating lymphocyte (TIL) therapy, T-cell receptor-engineered T-cell (TCR-T) therapy, and natural killer (NK) cell therapy - are emerging…
- Trial name
- NCT07813000
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 1,020 people
- Sponsor
- Zhejiang University
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT07170358)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
pMMR/MSS, Locally Advanced Rectal Carcinoma
16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer
Although standard neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC) effectively reduces local recurrence, radiotherapy-related toxicities and surgical complications severely impair patients' quality…
- Conditions
- pMMR/MSS, Locally Advanced Rectal Carcinoma, Fasting, Intermittent
- Trial name
- NCT07779694
- Testing
- 16-Hour Fasting, Serplulimab + chemotherapy
- Volunteers
- 51 people
- Sponsor
- Zhejiang University
Systemic Sclerosis (SSc)
Clinical Study of CD19 CAR-T in the Treatment of Refractory Systemic Sclerosis
This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-CD19 CAR-T cells in the treatment of childhood-onset systemic sclerosis
- Trial name
- NCT06792344
- Testing
- anti-CD19 CAR-T cells
- Where
- 2 sites in China, Christmas Island
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Polymyalgia Rheumatica
Induction and Tapering Therapy With Tofacitinib and Glucocorticoid in Patients With Polymyalgia Rheumatica
This will be efficacy and safety of Induction and Tapering Therapy with Tofacitinib and Glucocorticoid in patients with Polymyalgia Rheumatica (ITTG PMR): An open-label 52-week randomized controlled trial
- Trial name
- ITTGPMR (NCT06172361)
- Testing
- Prednisone+Tofacitinib, Prednisone
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zhejiang University
Cardiac and Respiratory Arrest
SST in Emergency Education
This study looks back at how the investigatorsll two different teaching methods work for training medical and nursing students in CPR (cardiopulmonary resuscitation), a life-saving emergency procedure used when someone's heart…
- Trial name
- SST (NCT07803861)
- Testing
- case-based scenario simulation teaching
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ovarian Mass, Adnexal Mass
An AI-Assisted Agentic System for Ultrasound Scanning and Diagnosis of Ovarian Lesions
Investigators developed an interactive agentic system designed to guide newly qualified sonographers in ovarian lesion scanning and improve their scanning quality and diagnostic performance toward expert-level standards.
- Trial name
- NCT07801209
- Testing
- non-AI assisted and then AI assisted, AI assisted and then non-AI assisted
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Pregnant Women
Association of Gestational Cardiovascular Health With Pregnancy Outcomes
Pregnancy is a critical period for cardiovascular health risk assessment and interventions to reduce the incidence of cardiovascular disease in both mother and child generations.
- Trial name
- NCT05776082
- Testing
- Questionnaire survey and specimen collection
- Where
- 3 sites in China, Rwanda
- Volunteers
- 5,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Generalized Anxiety Disorder (GAD)
Acupuncture for Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is a common mental disorder characterized by persistent excessive worry, which seriously affects patients' quality of life.
- Trial name
- NCT07798986
- Testing
- 2Hz electro-acupuncture, 100Hz electro-acupuncture, 2Hz/100Hz electro-acupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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