Clinical trials: sponsored by Zhejiang University
Stem Cell Transplant Complications, Oral Mucositis
Compound Staphylococcal Lysostaphin Vs. Chlorhexidine Mouthrinse for Oral Mucositis in Patients Undergoing Allo-HSCT
Oral mucositis (OM) is a common complication in patients receiving myeloablative conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT06791746
- Testing
- compound Staphylococcal lysostaphin mouthrinse, chlorhexidine mouthrinse
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Zhejiang University
Delirium
Effect of Nasal Spray Dexmedetomidine on Emergence Delirium Prevention in Total Hip Replacement
Emergence Delirium (ED) is a common postoperative complication refers to an acute brain dysfunction that occurs during the recovery from general anesthesia, which is mainly characterized by sudden attention and consciousness…
- Trial name
- NCT06579001
- Testing
- Nasal spray dexmedetomidine
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
BPD - Bronchopulmonary Dysplasia
Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, which is a major complication of very low and ultra-low preterm infants.
- Trial name
- MSC，BPD (NCT06788470)
- Testing
- MSC
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Relapsed/Refractory Acute Myeloid Leukemia(AML)
Clinical Study on the Safety and Efficacy of Autologous CD84 Chimeric Antigen Receptor T-Cell Therapy for Adult Relapsed/Refractory Acute Myeloid Leukemia.
Acute Myeloid Leukemia (AML) is an aggressive type of leukemia, with high relapse rate and poor long term survival in adults. Traditional treatment regimens mainly include chemotherapy and hematopoietic stem cell transplantation.
- Trial name
- NCT06786299
- Testing
- RD-IIT-001, CD84-CART
- Where
- China
- Volunteers
- 18 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bone Marrow Failure Syndrome
CD7 CAR-T Cell Sequential Allo-HSCT for Non-malignant Blood and Immune System Diseases
A Clinical Study on the Safety and Effectiveness of CD7 CAR-T Cell Sequential Allogeneic Hematopoietic Stem Cell Transplantation for Non-malignant Blood and Immune System Diseases
- Trial name
- NCT06787560
- Testing
- CD7 CAR-T cells injection, Allo-HSCT
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Schimke Immuno-osseous Dysplasia
Clinical Study on the Safety and Efficacy of CD7 CAR-T Cell Sequential Allo-HSCT and Kidney Transplantation in the Treatment of SIOD
A Clinical Study on the Safety and Effectiveness of CD7 CAR-T Cell Sequential Allo-HSCT and Kidney Transplantation in the treatment of Schimke immuno-osseous dysplasia
- Trial name
- NCT06769191
- Testing
- CD7 CAR-T cells injection, Allo-HSCT, Kidney Transplantation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Lymphedema Arm
Efficacy of Home-based Treatment for Breast Cancer-related Lymphedema
The goal of this clinical trials is to explore the effectiveness of home-based iymphedema treatment and the differences between the home-based and outpatient treatment.
- Trial name
- NCT06783543
- Testing
- Comprehensive detumescence treatment with education video, Comprehensive detumescence treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Unresectable or Metastatic Advanced Solid Tumors
A Dose Escalation and Dose Expansion Trial of WTX212A in the Treatment of Patients with Advanced Malignant Tumors
This trial is a multi-center, open-label investigator-initiated clinical study (IIT) to evaluate the safety, pharmacokinetics, pharmacodynamics and effectiveness of WTX212A injection in the treatment of patients with unresectable…
- Trial name
- NCT06026605
- Testing
- WTX212A
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Zhejiang University
Acute Lymphoblastic Leukemia, B Cell ALL
Inaticabtagene Autoleucel (Inati-cel; CNCT19) Treatment for Newly Diagnosed B-cell ALL Patients in CR1
This investigator-initiated, prospective, single-arm, open-label, single-center phase II study aims to evaluate the long-term survival benefit and safety of a commercial CD19 CAR-T product in newly diagnosed Philadelphia…
- Trial name
- JUVENTAS-ALL05 (NCT06777264)
- Testing
- Biological: single dose of Inaticabtagene autoleucel
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Perioperative Anemia
Effect of Perioperative Roxadustat in Elective Lumbar Interbody Fusion Surgery.
The goal of this clinical trial is to assess whether Roxadustat can reduce perioperative blood transfusions in patients with anemia undergoing elective lumbar interbody fusion surgery.
- Trial name
- PRELIFS (NCT06772272)
- Testing
- Roxadustat
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Cirrhosis
Spirulina Tablets Treat Liver Fibrosis/Cirrhosis
Spirulina (Spirulina platensis, SP) is a nutrient-rich blue-green algae that has been widely studied and applied in various health fields.
- Trial name
- NCT06770283
- Testing
- Spirulina tablet
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Patient Blood Management, Cardiac Surgery
Effect of the Combined Programme on Perioperative Anaemia（CPPA）
We used the preoperative intervention of iron sucrose in combination with human erythropoietin and vitamin C as an innovative combination therapy.
- Conditions
- Patient Blood Management, Cardiac Surgery, Iron Deficiency Anemia
- Trial name
- NCT05353348
- Testing
- Iron Sucrose, recombinant human erythropoietin, ascorbic acid, conventional treatment
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreas Cancer
Bortezomib Combined with PD-1 MAb and MFOLFIRINOX for Metastatic Pancreatic Cancer
This is an single-center, prospective, open-label clinical trial, to explore the safty and efficacy of combination of Bortezomib, Sindilizumab, and mFOLFIRINOX Chemotherapy (oxaliplatin, fluorouracil, irinotecan, leucovorin) in…
- Trial name
- CISPD-7 (NCT06572813)
- Testing
- Bortezomib Injection, Sintilimab, mFOLFIRINOX
- Where
- China
- Volunteers
- 63 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Breast Tumor
Sub-regional Tumor Segmentation Based on CEUS Perfusion Characteristics: Enhancing Breast Tumor Diagnosis
The goal of this study is to investigate breast cancer's internal heterogeneity and enhance diagnostic accuracy. The investigators aim to achieve this by utilizing Contrast-Enhanced Ultrasound (CEUS) technology, which provides…
- Trial name
- NCT06172270
- Where
- China
- Volunteers
- 339 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA)
A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases.
Ankylosing spondylitis, radiographically negative axial spondyloarthritis, psoriatic arthritis, polymyalgia rheumatica, Takayasu arteritis, giant cell arteritis, non-ocular Behcet's disease, and enthesitis-related arthritis are…
- Conditions
- Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Nr-axSpA, Polymyalgia Rheumatica (PMR)
- Trial name
- V-MIRACLE (NCT06766552)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Eye-tracking Technology, Medical Education
The Application of Eye-Tracking Technology in Perioperative Management and Education
The goal of this observational study is to explore the value of eye-tracking technology in perioperative management and teaching.
- Conditions
- Eye-tracking Technology, Medical Education, Perioperative Management, Attention Distribution
- Trial name
- NCT06766539
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Overactive Bladder (OAB)
Transcutaneous Tibial Nerve Stimulation Therapy in Children With Overactive Bladder
Overactive bladder (OAB) is a syndrome characterized by urinary urgency, often accompanied by frequency and nocturia, with or without urge incontinence, without urinary tract infection or other clear pathological changes.
- Trial name
- NCT06765629
- Testing
- Non-invasive Percutaneous Tibial Nerve Stimulation (TTNS) group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Occupational Burnout
A Survey Study on the Job Burnout of Chinese Endoscopy Nurses
Occupational burnout (burnout) was proposed by American psychologist Herbert Freudenberger in 1974, who it as a syndrome caused by prolonged exposure to workplace stress that is not successfully managed.
- Trial name
- NCT06766695
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric
NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL
The goal of this clinical trial is to determine whether pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients with negative deep minimal residue disease (MRD) can benefit from blinatumomab treatment.
- Conditions
- B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric, Minimal Residual Disease, Next Generation Sequencing (NGS)
- Trial name
- NCT06763302
- Testing
- Blinatumomab
- Volunteers
- 1,220 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Low Back Pain
Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain
This study tests the hypothesis that radial extracorporeal shock wave therapy (rESWT) in combination with the non-steroidal anti-inflammatory drug Celecoxib and the antispasmodic drug Eperisone (hereafter, "C-E drug therapy") is…
- Trial name
- NCT03337607
- Testing
- rESWT, Celecoxib, Eperisone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
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