Clinical trials: sponsored by Zhejiang University
Vertigo, Vestibular Diseases
China Dizziness and Vertigo Cohort Study （VERIDICAL STUDY）
The goal of this observational study is to characterize the clinical features, etiological distribution, and longitudinal outcomes of patients with dizziness and/or vertigo in real-world neurological and otolaryngological…
- Trial name
- dizziness (NCT07778901)
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Routine Angiography Follow-Up After Percutaneous Coronary Intervention in High-Risk Patients
Comparison of clinical outcomes between routine angiography follow-up and routine clinical follow-up after percutaneous coronary intervention in high-risk patients.
- Trial name
- NCT05923489
- Testing
- Routine Angiography Follow-up, Routine Clinical Follow-up
- Where
- China
- Volunteers
- 2,618 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Type B Aortic Dissection, Tevar
Research on Predicting Aortic Remodeling Following TEVAR for Type B Aortic Dissection Based on VDM and CFD
This study proposes a retrospective analysis that systematically integrates multidimensional biomechanical and anatomical data to construct an early and accurate predictive model for adverse aortic remodeling following thoracic…
- Conditions
- Type B Aortic Dissection, Tevar, CFD
- Trial name
- NCT07779291
- Testing
- Thoracic Endovascular Aortic Repair
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cervical Spinal Stenosis, Thoracic Spinal Stenosis
The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery
Postoperative delirium is a delirium that occurs within 7 days after surgery or before hospital discharge. It has been shown that combined POD can increase the incidence of postoperative pulmonary infections, deep vein thrombosis…
- Conditions
- Cervical Spinal Stenosis, Thoracic Spinal Stenosis, Lumbar Spinal Stenosis, Rotator Cuff Injury
- Trial name
- NCT06945926
- Testing
- oxytocin nasal spray
- Where
- China
- Volunteers
- 227 people
- Sponsor
- Zhejiang University
T-Cell Acute Lymphoblastic Leukemia, T-Cell Lymphoblastic Lymphoma
Chidamide Maintenance to Prevent Relapse After Allogeneic Hematopoietic Stem Cell Transplantation in Acute T-Lymphoblastic Leukemia/Lymphoma
This study evaluates whether chidamide maintenance therapy can effectively reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with high-risk T-cell acute lymphoblastic…
- Trial name
- CHI-HSCT (NCT07774377)
- Testing
- Chidamide, Control Group
- Volunteers
- 132 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Medical Education, Clinical Skills
AI-Assisted Feedback for Learning Standardized Tuina Skills
The goal of this educational study is to determine whether personalized feedback generated using sensor data and generative artificial intelligence (AI) can improve the learning of standardized Tuina skills among rehabilitation…
- Trial name
- AI-TUINA (NCT07767916)
- Testing
- AI-Supported Personalized Feedback, Sensor-Based Data Feedback, Traditional Instructor Feedback
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Critical Illness, Multiple Organ Dysfunction Syndrome
AI-Based Precision Transfusion Prediction Model in Critically Ill Patients
This multicenter observational study aims to develop and validate an artificial intelligence-based precision transfusion prediction model for critically ill patients.
- Conditions
- Critical Illness, Multiple Organ Dysfunction Syndrome, Blood Transfusion
- Trial name
- NCT07762131
- Testing
- Red Blood Cell Transfusion Exposure
- Volunteers
- 2,598 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Assessment of CT-FFR in Patients With CCS: A Prospective Multicenter Cohort Study
The ACCURATE-PRO study is an investigator-initiated, prospective, multicenter, observational, real-world cohort study. The core objective in managing chronic coronary syndrome (CCS) is to identify clinically significant…
- Trial name
- ACCURATE-PRO (NCT07659119)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intrahepatic Cholangiocarcinoma (Icc), Liver Injury
Protective Mechanisms of Phycocyanin in Partial Hepatectomy-Associated Liver Injury
The goal of this study is to find out whether phycocyanin, a natural protein from spirulina, can help protect the liver and support recovery in adults having part of their liver removed.
- Trial name
- NCT07760038
- Testing
- Phycocyanin, Maltodextrin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aortic Regurgitation, Aortic Valve Insufficiency
ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy
The overall purpose of ART trial is to establish the Safety and Efficacy of the J-VALVE Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in Patients with Grade≥3+ Native Aortic Regurgitation.
- Conditions
- Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency
- Trial name
- ART (NCT07453407)
- Testing
- J-VALVE Transfemoral Aortic Valve system, Commercially available surgical biological aortic valve replacement device
- Where
- 28 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Axillary Lymph Node Metastasis
A Prospective Multicenter Study of the TuFEst-LN Model for Axillary Lymph Node Status Assessment in Breast Cancer
Through the research of this project, we expect to validate the clinical utility of the TuFEst-LN model in assessing axillary lymph node status in breast cancer patients.
- Trial name
- PRO-TuFEst-LN (NCT07304934)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Medical Education, Cardiac Rehabilitation
Blended Cardiac Rehabilitation Training for Cardiology Residents
This randomized controlled trial compares supervised hospital-based practice with matched online activities as part of a common cardiac rehabilitation curriculum for cardiology residents.
- Trial name
- CR-BLEND (NCT07755878)
- Testing
- Common online cardiac rehabilitation curriculum, Matched supplementary online learning, Hospital-based case and practice sessions
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vestibular Migraine
A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention: Rimegepant Versus Flunarizine Non-inferiority Study
Vestibular migraine is a common condition that causes repeated episodes of dizziness or vertigo, often with migraine headaches, sensitivity to light and sound, and nausea.
- Trial name
- VERIFY (NCT07751497)
- Testing
- Rimegepant, Flunarizine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Zhejiang University
The Impact of Fexofenadine Hydrochloride on the Prognosis of Patients Post-Acute Myocardial Infarction
The goal of this study is o evaluate the prognostic effect of fexofenadine hydrochloride in patients with myocardial infarction
- Trial name
- NCT07381803
- Testing
- Fexofenadine 60 Mg Oral Tablet
- Where
- China
- Volunteers
- 2,804 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence
Ezetimibe for Arrhythmia Recurrence After AF Ablation
This single-center, prospective, single-blind randomized controlled pilot trial aims to explore whether oral ezetimibe can reduce the 6-month recurrence rate of atrial tachyarrhythmia after catheter ablation in patients with…
- Trial name
- EAFA (NCT07752758)
- Testing
- Ezetimibe, Standardized post-ablation clinical management
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
an Intelligent Teaching Agent for the "Epidemiology" Course of the MBBS Program, Students' Critical Thinking, Practical Ability and Learning Outcomes
Research and Application of an AI Agent-Based MBBS Course Assistant
Prior to the quasi-experiment, this study performed semi-structured interviews among Bachelor of Medicine and Bachelor of Surgery(MBBS) undergraduate students from the Belt and Road International Medical College, Zhejiang…
- Trial name
- NCT07752160
- Testing
- Socratic Agent for Guided Epidemiology, General LLM
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Coronary Artery Calcifications, Intravascular Lithotripsy
Intravascular Lithotripsy Versus Rotational Atherectomy for Severe Coronary Artery Calcification: A Prospective, Multicenter, Non-inferiority Randomized Controlled Trial
Severely calcified coronary lesions represent one of the major challenges in interventional cardiology. Severe coronary calcification increases the difficulty and complexity of percutaneous coronary intervention (PCI), impedes…
- Conditions
- Coronary Artery Calcifications, Intravascular Lithotripsy, Rotational Atherectomy, Intravascular Ultrasound
- Trial name
- LIRAC (NCT07750964)
- Testing
- intravascular lithotripsy, rotational atherectomy
- Volunteers
- 190 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lens Diseases, Cataract
Multicenter Study on the Use of Intraoperative OCT in the Diagnosis and Management of Lens Diseases
This multicenter retrospective study will collect clinical data to investigate the associations between preoperative and intraoperative anterior segment structural changes and postoperative surgical outcomes in patients with lens…
- Conditions
- Lens Diseases, Cataract, Age-related Cataract, Complicated Cataract
- Trial name
- NCT07741370
- Testing
- Intraoperative Optical Coherence Tomography
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
General Anesthesia, Aged
Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery
This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing…
- Conditions
- General Anesthesia, Aged, Intraoperative Hypotension, Anxiety
- Trial name
- NCT07746505
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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