Clinical trials: sponsored by Zhujiang Hospital
Parkinson's Disease
MAPT Haploid H1b and the Damage of BBB in Dorsal Medulla Oblongata and Autonomic Dysfunction in PD
This study mainly explored the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of…
- Trial name
- NCT05471713
- Testing
- Autonomic dysfunction
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Sepsis
Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock
In this prospective, single-center,randomized,controlled,single-blind clinical trial,Patients will be randomly assigned to receive granisetron or placebo for 4 days or until leaving the ICU(death or transfer from ICU to general…
- Trial name
- GRANTISS (NCT03924518)
- Testing
- Granisetron Hydrochloride
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhujiang Hospital
Bleeding, Ischemic Stroke
The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The purpose of this study is to determine whether Plasma Factor VIII Levels are related to the treatment of bleeding in ischemic stroke（IS）.
- Trial name
- NCT02677818
- Where
- China
- Sponsor
- Zhujiang Hospital
Peritoneal Dialysis, Inflammation
Association of MLR With Risk of Death and Cardiovascular Events in PD Patients
The current incidence of chronic kidney disease (CKD) in China is approximately 10.8%, with approximately 119 million patients. Among them, patients with end-stage renal disease (ESRD) are about 200-250 cases per million…
- Trial name
- NCT04238338
- Testing
- monocyte / lymphocyte ratio
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Zhujiang Hospital
Chronic Liver Disease
Delta Radiomics for Liver Function Evaluation
To evaluate the feasibility and efficacy of delta radiomics-derived index based on Gd-EOB-DTPA enhanced MRI as a new imaging biomarker for the quantitative assessment of liver function.
- Trial name
- NCT05296434
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Postpartum Depression
EEG Alterations of Uterine Contractions in the First Stage of Labor Predicting Postpartum Depression
Severe uterine contractions in labor can trigger emotional disorders including postpartum depression in women during the puerperium.
- Trial name
- NCT05217251
- Testing
- frontal alpha asymmetry in EEG
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Zhujiang Hospital
Type 2 Diabetes Mellitus and Fragility Fractures
A Prospective Cohort Study:Forecast Fracture Risk With a Serum Marker of Type 2 Diabetes in Guangzhou Community
The objective of this study is to find out the biochemical markers which have independent predictive value of fragility fractures risk with Type 2 diabetes in Guangzhou community and evaluate bone strength better and increase the…
- Trial name
- NCT03456271
- Where
- 5 sites in China
- Volunteers
- 99 people
- Sponsor
- Zhujiang Hospital
Liver Resection
The Evaluation of Surgical Decisions and Prognosis of the Radiomics and Watson Artificial Intelligence in Patients With Hepatocellular Carcinoma
The aim of this study was to evaluate the surgical decisions and prognosis of the radiomics and Watson artificial intelligence in patients with hepatocellular carcinoma.
- Trial name
- NCT03917017
- Testing
- Radiomics and Watson artificial intelligence
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Primary Liver Cancers
A Multicenter RCT Study of 3DV Technology in the Diagnosis and Treatment of PLC
Primary liver cancer is the most common malignant tumor of the liver. Radical surgery is the preferred treatment, but its 5-year recurrence rate is as high as 70%, which is often associated with incomplete surgical resection and…
- Trial name
- NCT05118451
- Testing
- 3 d visualization technology
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Zhujiang Hospital
Liver Cancer
Indocyanine Green Molecular Fluorescence Imaging Technique Using in Diagnosis and Treatment of Primary Liver Cancer
The of this study is to explore the clinical outcomes of indocyanine green molecular fluorescence imaging in local resection of primary hepatocellular carcinoma (CNLC Ⅰa stage).
- Trial name
- ICGMFITinPLC (NCT05160740)
- Testing
- Indocyanine green for injection
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Zhujiang Hospital
Vascular Anomalies
Efficacy and Safety of Rapamycin to Complex Vascular Anomalies in Pediatric Patients
KHE and TA are rare tumors and some of the cases may lead to life-threatening complications including Kasabach-Merritt Phenomenon.
- Trial name
- NCT04598204
- Testing
- Treatment with oral rapmycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital
Endometriosis
Omics Sequencing of Specimen Derived From Patients With Endometriosis
Endometriosis is a type of chronic inflammatory gynecological disease, mainly took place in peritoneal cavity. In order to investigate the possible correlation between microbes and endometriosis, the investigators planed to…
- Trial name
- NCT05086484
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Relapsed/Refractory Acute Myeloid Leukemia(AML)
CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a group of genetically highly heterogeneous malignant disease . The disease is the most common type of adult acute leukemia. Overall survival (OS) was less than 50% in 5 years.
- Trial name
- AML (NCT03473457)
- Testing
- CART therapy in Acute myeloid leukemia(AML)
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Zhujiang Hospital
Catheter Thrombosis, Catheter-Related Infections
The Central Venous Catheter Related Complications in Critically Ill Patients
In this prospective clinical study, the researchers investigate the incidence of catheter-related thrombosis and catheter-related infection during indwelling central venous catheterization in critically ill patients, and analyzed…
- Conditions
- Catheter Thrombosis, Catheter-Related Infections, Central Venous Catheter Related Bloodstream Infection, Central Venous Catheter Thrombosis
- Trial name
- NCT03841240
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital
Chronic Airway Disease
Impulse Oscillation to Evaluate Diagnostic Efficacy in Patients With Chronic Airway Disease
The aim of the research is to explore the diagnostic efficacy of impulse oscillation (IOS) before and after bronchial provocation test (BPT) and bronchial dilation test (BDT) in chronic airway disease.
- Trial name
- NCT04668027
- Testing
- impulse oscillation（IOS）, bronchial provocation test(BPT), bronchial dilation test(BDT)
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Leukemia, Acute
Population Pharmacokinetics and Safety of Oral Posaconazole in Children With Leukemia
This study is designed to evaluate the safety, efficacy and Population Pharmacokinetics of Oral Posaconazole in Children with leukemia.
- Trial name
- NCT04194086
- Testing
- posaconazole oral suspensions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Zhujiang Hospital
Cough Variant Asthma
Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
- Trial name
- NCT03573284
- Testing
- fractional exhaled nitric oxide(FeNO), impulse oscillometry(IOS)
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Zhujiang Hospital
Magnetic Resonance Imaging
The Application of Glucose CEST MR Imaging in Brain Tumor
Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier…
- Trial name
- NCT04945499
- Testing
- d-glucose
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Cerebral Small Vessel Diseases
Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease
This study was a multicenter, prospective, randomized controlled trial. In this study, 510 patients with cognitive impairment of cerebral small vessel disease who met the inclusion criteria are randomly included in multiple…
- Trial name
- NCT04041349
- Testing
- mouse nerve growth factor
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital