Clinical trials: sponsored by Case Comprehensive Cancer Center
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Magnetic Resonance Guided Focal Stereotactic Body Radiation Therapy for Localized Prostate Cancer
This pilot clinical trial studies magnetic resonance (MRI)-guided focal stereotactic radiosurgery (SRS) in treating patients with low- or intermediate-risk localized prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer
- Trial name
- NCT02163317
- Testing
- stereotactic radiosurgery, magnetic resonance imaging, quality-of-life assessment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Stage IV Non-Small Cell Lung Cancer
Pembrolizumab Alone or Sequentially Following Single Fraction Non-ablative Radiation to One of the Target Lesions, in Previously Treated Patients With Stage IV NSCLC
The goal of this clinical trial is to determine if low single palliative dose radiation to the lung cancer will improve your immune response against the tumor and if sequential treatment with pembrolizumab (the study drug) would…
- Trial name
- NCT02658097
- Testing
- Pembrolizumab, Single Fraction Radiation Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Trastuzumab in Treating Older Women With Early-Stage Breast Cancer
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00796978
- Testing
- trastuzumab, laboratory biomarker analysis, adjuvant therapy
- Where
- 11 sites in United States
- Volunteers
- 56 people
- Sponsor
- Cynthia Owusu, MD
Sickle Cell Disease, Sickle Cell Anemia
Hematopoietic Stem Cell Transplant for Sickle Cell Disease
This is a study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem cell transplants.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, SCD
- Trial name
- NCT02065596
- Testing
- Fludarabine, Hematopoietic Stem Cell Transplant (HSCT)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Comprehensive Cancer Center
Autologous Transplant, Myeloma
Mycobiome Supporting Diet to Reduce GI Toxicity Associated With ASCT
The purpose of this study is to determine if this specific Mycobiome Supporting Diet (MSD diet) can help reduce gut inflammation during post-transplant period.
- Trial name
- NCT04685525
- Testing
- Mycobiome Supporting Diet
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Rectal Cancer
Circulating Tumor DNA to Monitor the Efficacy of Total Neoadjuvant Therapy for Rectal Cancer
The purpose of this study is to use the SignateraTm assay created from rectal tumor biopsies to monitor participants' blood for fragments of DNA shed by tumor cells.
- Trial name
- NCT05356585
- Testing
- SignateraTM assay
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma
Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This phase II trial studies the efficacy (activity), and tolerability of curcumin and cholecalciferol combination in treating patients with previously untreated stage 0-II chronic lymphocytic leukemia or small lymphocytic…
- Conditions
- Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma, Stage 0 Chronic Lymphocytic Leukemia, Stage I Chronic Lymphocytic Leukemia
- Trial name
- NCT02100423
- Testing
- curcumin, cholecalciferol, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Paolo Caimi, MD
Post-transplant Lymphoproliferative Disorder
Rituximab and Acalabrutinib in Newly Diagnosed B Cell Post Transplant Lymphoproliferative Disorder
The purpose of this study is to evaluate how effective rituximab and acalabrutinib are when given as a combination treatment for newly diagnosed B cell post transplant lymphoproliferative disorder (PTLD).
- Trial name
- NCT04337827
- Testing
- Rituximab, Acalabrutinib, CT scans
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Deepa Jagadeesh
Multiple Myeloma
Melphalan on Disease Burden Measured by Next Generation Sequencing Before AHCT (Autologous Hematopoietic Cell Transplant) for Multiple Myeloma
The purpose of this study is to see if Multiple Myeloma (MM) cells are sensitive to the chemotherapy used in transplant or not. The main chemotherapy agent utilized in stem cell transplant is melphalan.
- Trial name
- AHCT (NCT05013437)
- Testing
- Evomela, Next Generation Sequencing, Prochlorperazine
- Where
- United States
- Sponsor
- Koen van Besien
Metastatic Renal Cell Carcinoma
Intermittent Therapy in Metastatic Renal Cell Carcinoma Patients Treated With Ipilimumab and Nivolumab
This study is being done with patients with advanced kidney cancer (also called renal cell carcinoma or RCC). This is a research study involving the use of the drug Nivolumab (also known as Opdivo®).
- Trial name
- NCT03126331
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Renal Cell Carcinoma, Kidney Cancer
Neoadjuvant MEDI 4736 +/- Tremelimumab in Locally Advanced Renal Cell Carcinoma
The purpose of this study is to investigate the safety and feasibility of administering investigational drugs (meaning not Food and Drug Administration (FDA)-approved for kidney cancer) prior to surgical treatment for kidney…
- Trial name
- NCT02762006
- Testing
- Durvalumab, Tremelimumab
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Moshe Ornstein
NSCLC, Non-small Cell Lung Cancer
Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC
Investigating potential of controlling brain metastases in patients with EGFR positive NSCLC.
- Trial name
- NCT03535363
- Testing
- Osimertinib
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Case Comprehensive Cancer Center
Smoking Behaviors
C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)
The purpose of this research is to understand how flavor affects young adult's perceptions of little cigar or cigarillo use.
- Trial name
- NCT04358705
- Testing
- Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey
- Where
- United States
- Volunteers
- 658 people
- Sponsor
- Case Comprehensive Cancer Center
Adolescent and Young Adult Cancers
CyberCycling to Reduce Therapeutic Side Effects and Improve Quality of Life in AYA Cancers
Only a few clinical trials evaluating the potential benefits of exercise have been conducted in adolescents and young adults (AYA) with cancer and, no prior studies have evaluated the potential effects of 'cybercycling'…
- Trial name
- NCT02916472
- Testing
- CyberCycling, Stretching, Resistance Bands
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Case Comprehensive Cancer Center
Non-Small Cell Lung Cancer
Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC
The purpose of this study is to treat participants with the combination of durvalumab (the study drug) and proton beam therapy. Proton beam therapy is a type of radiotherapy (RT) with a unique characteristic where the proton…
- Trial name
- NCT03818776
- Testing
- Durvalumab, Proton beam therapy RT
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Reconstruction
Free Flap Breast Reconstruction Using Virtual Surgical Planning and 3-D Modeling
The purpose of this study is to determine if 3D modeling and Virtual Planning Surgery can improve the clinical outcome with patient who have a mastectomy requiring breast reconstruction.
- Trial name
- NCT03949491
- Testing
- 3D medical models
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Case Comprehensive Cancer Center
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma
This phase II trial studies how well oxaliplatin, leucovorin calcium, and fluorouracil followed by surgery and response based concurrent chemotherapy and radiation therapy works in treating patients with cancer of the esophagus…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Gastric Cardia, Stage IIIA Esophageal Cancer
- Trial name
- NCT02037048
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Digital PET/CT Using [Ga-68]PSMA for Characterization of Prostate Lesions
The purpose of this study is to evaluate a radioactive diagnostic study drug, which is called Gallium-68 Prostate Specific Membrane Antigen ([Ga-68]PSMA) for characterization of prostate abnormalities.
- Trial name
- NCT04867603
- Testing
- [Ga-68]PSMA, PET/CT imaging
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Norbert Avril, M.D.
Breast Cancer
Paclitaxel Plus Radiation Therapy in Treating Women With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00006256
- Testing
- paclitaxel, adjuvant therapy, radiation therapy
- Where
- 9 sites in United States
- Volunteers
- 44 people
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Pancreatic Adenocarcinoma
Regorafenib Plus Gemcitabine in Metastatic Pancreatic Cancer
This phase II trial studies how well regorafenib and gemcitabine hydrochloride work as second-line therapy (treatment given when initial treatment doesn't work) in treating patients with pancreatic cancer that has spread to other…
- Trial name
- NCT02383433
- Testing
- Regorafenib, Gemcitabine Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center