Clinical trials: not yet recruiting
Chronic Pain, Sickle Cell Disease
Focused Ultrasound Neuromodulation for Chronic Pain
This study will evaluate the feasibility, tolerability, and preliminary analgesic effects of individualized Precision Confidence Mapping-guided low-intensity focused ultrasound neuromodulation in adults with chronic pain.
- Conditions
- Chronic Pain, Sickle Cell Disease, Chronic Pelvic Pain Syndrome
- Trial name
- NCT07910396
- Testing
- Focused PCM-Guided CMN LIFU, Unfocused Control LIFU
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Immune Related Disorder, Tissue Damage
Clonal Fetal Mesenchymal Stem Cells (cfMSCs) for the Control of Immune-related Disorders
The primary objectives are to evaluate the safety and efficacy of infusion of the third party fully-characterized clonally derived fetal MSCs (cfMSCs) for the control of severe symptoms associated with acute and chronic…
- Trial name
- NCT03123458
- Testing
- clonal fetal MSCs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Primiparity (First-Time Mothers), Breastfeeding
The Effect of Music Play and Stress Ball Application on Placental Separation Time, Episious Pain and Breastfeeding Success
Although the female body and fetus are physiologically equipped to carry out the birthing process, the increasing medical interventions in the birthing process today are pushing women into the background during labor.
- Conditions
- Primiparity (First-Time Mothers), Breastfeeding, Episiotomy, Labour
- Trial name
- NCT07706881
- Testing
- music performance, stress ball squeezing, music listening and stress ball squeezing
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Bitlis Eren University
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA
Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease: A Randomized Controlled Trial
To compare the efficacy of fixed-dose versus treat-to-target statin regimens in achieving the predefined LDL-C target at 12 weeks in patients with established ASCVD.
- Conditions
- Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA, Cardio Vascular Disease
- Trial name
- NCT07909915
- Testing
- Dose adjustment of statins, no dose adjustment
- Where
- Pakistan
- Volunteers
- 178 people
- Sponsor
- Rehman Medical Institute - RMI
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Pain
Screening Protocol
This study is a screening evaluation for volunteers who are interested in participating in National Center for Complementary and Integrative Health (NCCIH) research studies about pain and related processes, such as emotion, mood…
- Trial name
- NCT07712874
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Food Choices
Environmental Harm Menu Labels and Overall Dietary Quality
The primary objective of this study is to evaluate whether repeated exposure to environmental harm menu labels on fast-food restaurant menus changes overall dietary quality.
- Trial name
- MENU (NCT07910617)
- Testing
- Control (QR Code) Menu Labels, Traffic-Light Style Environmental Harm Menu Labels
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Femoropopliteal In-Stent Restenosis (ISR)
Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis
Femoropopliteal in-stent restenosis (ISR) remains an important cause of recurrent symptoms and repeat revascularization after lower-extremity endovascular treatment.
- Trial name
- NCT07277218
- Testing
- Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy
- Where
- 10 sites in China
- Volunteers
- 600 people
- Sponsor
- Chunshui He
Psychological Resilience, Nursing Students
The Effect of Happiness Workshops on Nursing Students' Levels of Psychological Resilience
This study was designed as a randomized controlled trial to determine the effect of positive psychology-based happiness workshops on the psychological resilience levels of nursing students.
- Trial name
- NCT07910890
- Testing
- Positive Psychology-Based Happiness Workshops
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Healthy
Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Background: Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat.
- Trial name
- NCT06120244
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity
Background: Obesity affects 1 in 5 children in the United States. Childhood obesity often persists into adolescence and adulthood.
- Trial name
- NCT07437976
- Testing
- Weight loss intervention, No Weight loss intervention
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Thyroid Cancer
177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer
Background: Oncocytic (Hurthle cell) thyroid cancer (HTC) is a rare disease with few treatment options. Researchers are developing a radioactive drug that targets a protein that appears in high numbers on HTC cancer cells.
- Trial name
- NCT06991738
- Testing
- 68Ga-DOTA-TATE PET Scan, Amino acid infusions, 177Lu-DOTA-EB-TATE
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Glioma Patients
Flubendazole Added to Standard Concurrent Chemoradiotherapy With Temozolomide in Patients With High-Grade Glioma
This study To evalute the efficacy and safety of adding flubendazole to standard concurrent chemoradiotherapy with temozolomide in patients with high grade glioma and also to evaluate DFS,OS for those patients in clinical…
- Trial name
- NCT07847476
- Testing
- Flubendazole
- Volunteers
- 122 people
- Sponsor
- Assiut University
Inguinal Hernia, Incarcerated Inguinal Hernia
Bassini Repair Versus Desarda Technique in Urgent Complicated Inguinal Hernia Repair
Inguinal hernias occur when abdominal contents, such as intestine or fat, protrude through a weakness in the lower abdominal wall.
- Conditions
- Inguinal Hernia, Incarcerated Inguinal Hernia, Strangulated Inguinal Hernia
- Trial name
- NCT07910240
- Testing
- Bassini Inguinal Herniorrhaphy, Desarda Inguinal Hernia Repair
- Volunteers
- 70 people
- Sponsor
- Assiut University
Preeclampsia Severe, Preeclampsia Postpartum
Biomarkers in Management of Post Partum Preeclampsia
Participants are recruited for a research study about how lab values change following delivery in people with Preeclampsia with Severe Features.
- Trial name
- NCT07478055
- Testing
- Magnesium Sulfate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Alexander Harrison
Head & Neck Cancer
Gut-Liver-Muscle Axis in Cancer Cachexia
The purpose of this study is to determine if consuming a nutritional supplement before surgery affects weight loss, inflammation, and muscle in people with head and neck cancer cachexia.
- Trial name
- NCT07911150
- Testing
- Impact Advanced Recovery (Impact AR), Boost® High Protein + Beneprotein®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
X-linked Adrenoleukodystrophy
IT and IV Lentiviral Gene Therapy for X-ALD
This is a Phase I/II clinical trial of gene therapy for treating X-linked adrenoleukodystrophy using a high-safety, high-efficiency, self-inactivating lentiviral vector (LV) TYF-ABCD1 to functionally correct the defective gene.
- Trial name
- NCT03727555
- Testing
- Intrathecal and intravenous LV gene therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Post-Acute COVID-19 Syndrome
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years.
- Trial name
- NCT07388550
- Testing
- Keytruda
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Total Knee Arthroplasty, Knee Osteoarthristis
Application of Perinatal Derivatives in Total Knee Arthroplasty
This pilot study investigators whether the use of perinatal derivatives during knee replacement, in the form of an injection around the joint and patch over the knee joint incision, improves patient outcomes (including…
- Trial name
- NCT07908342
- Testing
- Intraoperative application of CTM Flow and CTM Thick, Total knee arthroplasty (TKA)
- Volunteers
- 48 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
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