Clinical trials: sponsored by Institut Pasteur
Influenza
Clinical Efficacy of Trivalent Live-Attenuated Influenza Vaccine (LAIV) Among Children in Senegal
This study will provide the Senegal Ministry of Health with data on the clinical efficacy of the Live-Attenuated Influenza Vaccine (LAIV). This data will inform future policy considerations for influenza vaccine.
- Trial name
- NCT01854632
- Testing
- SIIL Live Attenuated Influenza Vaccine
- Where
- Senegal
- Volunteers
- 1,761 people, healthy volunteers welcome
- Sponsor
- PATH
Individuality
Genetic & Environmental Determinants Of Immune Phenotype Variance: Establishing A Path Towards Personalized Medicine
The purpose of this study is to assess the determinants of immunologic variance within the general healthy population.
- Trial name
- LabExMI (NCT01699893)
- Testing
- unique arm
- Where
- France
- Volunteers
- 1,012 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Vivax Malaria
Assessment of Plasmodium Vivax Chloroquine Resistance in Cambodia:
The investigators propose to leverage the unique infrastructures and expertise of National Centre for Parasitology Entomology and Malaria Control and the Pasteur Institute in Cambodia and combine modern fieldwork, including a…
- Trial name
- CRePViCam (NCT02118090)
- Testing
- Chloroquine sulfate, DHA-PP
- Where
- Cambodia
- Volunteers
- 73 people
- Sponsor
- Institut Pasteur, Cambodia
Glycaemia
Glycaemic and Insulinaemic Responses After Consumption of FOS.
The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.
- Trial name
- GLYCOFOS-cake (NCT02352857)
- Testing
- Sugar, FOS
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Glycaemia
Glycaemic and Insulinaemic Responses After Consumption of FOS.
The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.
- Trial name
- GLYCOFOS-cream (NCT02353403)
- Testing
- Sugar, FOS
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Ascaris Lumbricoides, Ascaris Suum
Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Objectives: The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH). The primary objective is: (1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against…
- Conditions
- Ascaris Lumbricoides, Ascaris Suum, Trichuris Trichiura, Trichuris Vulpis
- Trial name
- ConWorm (NCT01379326)
- Testing
- Mebendazole
- Where
- 9 sites in Argentina, Australia and 6 more
- Volunteers
- 250 people
- Sponsor
- University Ghent
Prebiotics Effect
Prebiotics Change Microflora and Decrease LPS
The purpose of the present study was to establish the prebiotic effect of a new xylo-oligosaccharides (XOS) and of an inulin-and-XOS mixture (INU-XOS) and to determine their effect on endotoxaemia (lipopolysaccharides (LPS)) and…
- Trial name
- PIB (NCT02287844)
- Testing
- XOS, INU-XOS
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Chronic Hepatitis C
Evaluation of the National Treatment Program of Hepatitis C in Egypt
The aim of the study is to analyse data coming from two treatment centres of the National Treatment Program Centres of hepatitis C in Egypt
- Trial name
- eNTC (NCT02101177)
- Where
- 2 sites in Egypt
- Sponsor
- ANRS, Emerging Infectious Diseases
Bacterial Infections
Children's Antibiotic Resistant Infections in Low Income Countries
The main challenge of the ChARLI program is to assess the clinical burden of severe neonatal and childhood bacterial infections in low-income countries,in particular those caused by antibiotic resistant bacteria.
- Trial name
- ChARLI (NCT02074865)
- Testing
- biological samples
- Where
- Madagascar
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Benign Breast Disease, Breast Cancer
Prolactin Receptor and Breast Diseases
Prolactin is known to play an important role in breast development and differentiation. Thus proliferative breast diseases are good models to unravel PRl / PRLR function in proliferative processes.
- Trial name
- Prolacsein (NCT00842465)
- Testing
- blood collection for hormonal status analysis, breast Biopsy or surgery, blood collection
- Where
- France
- Volunteers
- 735 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Influenza
Inactivated Influenza Vaccine Effectiveness in Tropical Africa
Influenza, a highly communicable acute respiratory disease, is one of the major infectious disease threats to the human population.
- Trial name
- NCT00893906
- Testing
- seasonal trivalent inactivated influenza vaccine, inactivated polio vaccine
- Where
- Senegal
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- PATH
Age-related Macular Degeneration
Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment
This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical…
- Trial name
- ALGOVUE (NCT01480700)
- Testing
- Nutritional study
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Melanoma
Safety and Toxicity Study of Vaccination for Advanced Metastatic Melanoma Patients
In this phase I study, the investigators want to vaccine with THERAVAC® (an inactivated toxin coupled to melanoma antigen) some patients with advanced metastatic melanoma disease.
- Trial name
- THERAVAC (NCT01331915)
- Testing
- Theravac
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Schistosomiasis, Anemia
Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their…
- Conditions
- Schistosomiasis, Anemia, Underweight, Stunting
- Trial name
- SchistoVAN (NCT01553552)
- Where
- Senegal
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
Whooping Cough, Malaria
Study of the Environmental Factors Modulating Children Immune Response in Northern Senegal
Longitudinal survey in Northern Senegal to investigate the environmental factors modulating the immune response to childhood vaccines and to malaria.
- Conditions
- Whooping Cough, Malaria, Malnutrition
- Trial name
- AnoPalAnoVac (NCT01545115)
- Where
- Senegal
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
HIV
Study to Evaluate the Dosage and Safety of Two Intramuscular Injections of an Investigational Clade B HIV Vaccine
This study aimed to evaluate the safety and reactogenicity of two intramuscular injections of two different dosages of an investigational clade B HIV vaccine.
- Trial name
- NCT01320176
- Testing
- Investigational HIV vaccine dose A, Investigational HIV vaccine dose B
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Breast Cancer
Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer
This project consists on the realization followed by the clinical validation of two medical instruments dedicated to the precise sentinel lymph nodes identification and localization in the case of breast cancer: an intra…
- Trial name
- NCT00357487
- Testing
- peroperative scintillating probe, operative gamma camera
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Strasbourg, France
HIV Infections
Immunology of the Infection Perinatal
ANRS-EP38-IMMIP is a non interventional study. A single blood sample (30 mL) was drawn during a hospital visit for clinical follow-up. Immunological assays were performed on fresh blood.
- Trial name
- EP38 (NCT01055873)
- Testing
- A single blood sample (30 mL)
- Volunteers
- 93 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Healthy
Safety and Efficacy Study of Plasmodium Falciparum LSA-3 Malaria Vaccine
Malaria is responsible for over 2 million deaths each year. The development of an efficient vaccine would present by far the best solution for solving this disastrous situation.
- Trial name
- LSA-3-rec (NCT00509158)
- Testing
- arm I: PfLSA-3-rec with aluminium hydroxide as adjuvant, arm 2: PfLSA-3-rec with Montanide Isa 720 as adjuvant
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Fever, Suspected Malaria
ACT for the Home Management in Malagasy Children
The purpose of this study is to assess the feasibility, the acceptability and the effectiveness of the use of the Artesunate + Amodiaquine Fixed Dose Combination for the home management of presumed malaria in Malagasy children by…
- Trial name
- NCT00612547
- Testing
- Artesunate + Amodiaquine Fixed Dose Combination (CoArsucam)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- National Malaria Control Programme, Madagascar