Clinical trials: sponsored by Emory University
Breast Cancer, Ovarian Cancer
Evaluating an Evidence-Based Family History Screening Program Adapted to Increase Reach and Uptake of Screening for BRCA-Associated Cancers in Rural Public Health Clinics
This clinical trial adapts and evaluates the effectiveness of a family history screening program (GA CORE) for increasing uptake of genetic screening for BRCA-associated cancers in women who have received care in rural public…
- Trial name
- RSPH5973-23 (NCT06760507)
- Testing
- Adapted Family History Screening Program
- Where
- United States
- Volunteers
- 3,209 people, healthy volunteers welcome
- Sponsor
- Emory University
IgA Monoclonal Gammopathy, IgG Monoclonal Gammopathy
Rifaximin in Patients With Monoclonal Gammopathy
This trial studies how well rifaximin works in treating patients with monoclonal gammopathy. Antibiotics, such as rifaximin, may help to kill bacteria in the intestines and reduce the abnormal protein or cells in patients with…
- Conditions
- IgA Monoclonal Gammopathy, IgG Monoclonal Gammopathy, IgM Monoclonal Gammopathy, Light Chain Deposition Disease
- Trial name
- NCT03820817
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Sickle Cell Disease
Biotin-RBC Transfusion in SCD
This is a single-arm, mechanistic clinical trial to measure predictors of senescence and the in vivo survival of transfused red blood cells (RBCs) in individuals with sickle cell disease (SCD) receiving chronic transfusion…
- Trial name
- NCT04426591
- Testing
- Biotin Labeled Red Blood Cells, Pathogen-reduced Biotin Labeled Red Blood Cells
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Marianne Yee
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Asthma in Children
Asthma Navigator Intervention to Improve Health Equity in Children
The goal of this study is to improve health equity in children aged 5-16.9 years admitted to the PICU for asthma. The objectives are: To identify the factors related to differential experiences of asthma self-management To pilot…
- Trial name
- NCT06513832
- Testing
- The asthma navigator
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Colorectal Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma
Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer
This phase Ib trial studies the side effects and best dose of Hsp90 inhibitor XL888 when given together with pembrolizumab in treating patients with advanced gastrointestinal cancer that has spread to other places in the body.
- Conditions
- Colorectal Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Recurrent Colorectal Carcinoma, Recurrent Pancreatic Carcinoma
- Trial name
- NCT03095781
- Testing
- XL888, Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- Emory University
Stroke, Acute, Ischemic Stroke, Acute
Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition
Most stroke patients are initially evaluated at the closest hospital but some need to be transferred to a hospital that can provide more advanced care.
- Conditions
- Stroke, Acute, Ischemic Stroke, Acute, Hemorrhagic Stroke
- Trial name
- HI-SPEED (NCT06094478)
- Testing
- HI-SPEED Protocol
- Where
- 8 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Chicago
Type 1 Diabetes
Expansion of the T1DES Pilot to a Public Hospital
Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-30 years with type 1 diabetes (T1D).
- Trial name
- NCT06494722
- Testing
- Diabetes Education, T1DES
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Sports Medicine Injuries
Effect of Personalized Pain Coaches After Orthopaedic Surgery for Patients With Sports Medicine Injuries
Patients experiencing sports medicine-related injuries are particularly vulnerable to developing both chronic pain and experiencing prolonged opioid use.
- Trial name
- NCT05821699
- Testing
- LCS (Life Care Specialist), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 148 people
- Sponsor
- Emory University
Communication Disorder, Childhood, Autism
Evaluating Georgia Part C Implementation Outcomes
This study aims to answer the question: What is the best way to help Early Intervention (EI) providers deliver high-quality services to children with communication delays for autism? The primary goal of this project is to examine…
- Trial name
- NCT07148258
- Testing
- Project ImPACT Training As Usual, Project ImPACT Training Plus Co-Production, Routine Project ImPACT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Depression, Suicidality
Assessing Improvements in Mood and Sleep Trial
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt).
- Conditions
- Depression, Suicidality, Sleep
- Trial name
- AIMS (NCT06639477)
- Testing
- Treatment As Usual, Active Condition, Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- University of Pittsburgh
Stress Disorders, Post-Traumatic
Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life.
- Trial name
- ANG-P (NCT02560805)
- Testing
- Microneurography, Combat virtual reality video clip, Handgrip Exercise
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Emory University
Cystic Fibrosis
Role of Body Fat Distribution in Metabolic and Pulmonary Decline in Cystic Fibrosis (ORBIT-CF)
Nutrition and body composition, the amount of muscle and fat in the body, has a role in overall health. This study wants to learn more about how nutrition and body composition affects health outcomes like glucose tolerance and…
- Trial name
- NCT04002882
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Emory University
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Chronic Kidney Disease
Sympatholysis in Chronic Kidney Disease
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e.
- Trial name
- Sym-CKD (NCT02411773)
- Testing
- Sodium Bicarbonate, Exercise Training, Control to Exercise (Stretching)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Emory University
Infertility, Pregnancy
Lifestyle and Fertility Study on Antioxidant Status, Diet and Early Pregnancy
Researchers believe that certain lifestyle factors can influence a couple's ability to conceive and have a baby. The ISIS Study will look at the health habits of couples who are planning their first pregnancy, and then attempt to…
- Conditions
- Infertility, Pregnancy, Fertility, Nutrition
- Trial name
- NCT00642590
- Where
- 2 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Renal Insufficiency, Chronic
Neurovascular Transduction During Exercise in Chronic Kidney Disease
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and to explore what causes an increase in blood pressure during exercise (i.e.
- Trial name
- NeurovEx (NCT02947750)
- Testing
- 6R-BH4, Folic acid, Exercise training
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer
This phase II trial examines transcutaneous electrical nerve stimulation (TENS) in patients with stage I-III breast cancer with chemotherapy induced peripheral neuropathy.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05368428
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
Radiosurgery Before Surgery for the Treatment of Brain Metastases
This early phase I trial identifies the side effects of stereotactic radiosurgery before surgery in treating patients with cancer that has spread to the brain (brain metastases).
- Trial name
- NCT04895592
- Testing
- Dexamethasone, Resection, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Pediatric Cancer
Video Inspired Discussions About Ethical Outcomes in Pediatrics
The goal of this clinical trial is to learn if the VIDEO-PEDS intervention works to improve Goals of Care communication between clinicians and parents of children with cancer.
- Trial name
- VIDEO-PEDS (NCT06786104)
- Testing
- VIDEO-PEDS, VIDEO-PEDS pilot, Focus Group
- Where
- 4 sites in United States
- Volunteers
- 567 people
- Sponsor
- Massachusetts General Hospital
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