Clinical trials: sponsored by Unity Health Toronto
Pain, Disruption or Dehiscence of Closure of Sternum or Sternotomy
Use of a Support Bra to Reduce Pain and Improve Surgical Healing in Women Undergoing Sternotomy for Cardiac Surgery
The primary purpose of this study is to examine whether a properly fitted support bra on females improves their quality of life post-sternotomy. Specifically, does a support bra reduce discomfort, pain and wound dehiscence.
- Conditions
- Pain, Disruption or Dehiscence of Closure of Sternum or Sternotomy, Quality of Life
- Trial name
- NCT02453945
- Testing
- Adjustable Support Bra
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
The Effect of Viscous Fiber on Glycemic Control in Individuals With Diabetes
Purpose of Study (The Effect of Viscous Fiber on Glycemic Control (VF \& GC) in Individuals with Diabetes Mellitus. According to the World Health Organization, about 347 million individuals are living with diabetes.
- Trial name
- VF&GC (NCT02629263)
- Testing
- Viscous Fiber
- Where
- Canada
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Risk Factor, Hypercholesterolemia
The Effect of Viscous Dietary Fibers on LDL-cholesterol
This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.
- Trial name
- NCT04133805
- Testing
- viscous fiber
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity, Morbid, Stem Cells
Effect of Weight Loss Surgery on Stem Cells.
Obesity and diabetes are linked to increased risk for health problems such as heart attack, stroke, and death. At the cellular level, obesity and diabetes increase levels of harmful inflammatory cells (M1 macrophages) and…
- Conditions
- Obesity, Morbid, Stem Cells, Cardiovascular Morbidity
- Trial name
- NCT04132531
- Testing
- Bariatric (weight loss) surgery
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Fine Motor Function Deficit and Visual Neglect Post-stroke
iPad Technology for HOME Rehabilitation in Patients After Stroke: iHOME Acute/Chronic
A pilot randomized, two parallel group study comparing an iPad software game application versus standard care in post-stroke patients.
- Trial name
- NCT01836159
- Testing
- iPad Intervention, Standard/ Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Unity Health Toronto
Arthroplasty, Replacement, Knee
COPE: Cannabinoids to Obviate Pain Experiment After Knee Replacement
Total knee replacement is a major and painful orthopaedic (joint and bone) surgery where the knee joint is replaced with an artificial joint.
- Trial name
- COPE (NCT03675971)
- Testing
- Cannabinol
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest, Sepsis
Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry
Rescu Epistry includes data points pertaining to prehospital and in-hospital clinical treatments and responses to therapy, survival to discharge and functional outcome data for all cases.
- Conditions
- Cardiac Arrest, Sepsis, Trauma, Stroke
- Trial name
- NCT04110912
- Testing
- This is a registry and no interventions are taking place.
- Where
- 3 sites in Canada
- Sponsor
- Unity Health Toronto
Social Determinants of Health, Poverty
Implementation and Impact of an Online Tool Used in Primary Care to Improve Income Security
We will evaluate the acceptability, feasibility and impact of an online tool that helps patients identify financial benefits that they are entitled to at six clinic sites over a three month period.
- Conditions
- Social Determinants of Health, Poverty, Social Isolation, Social Marginalization
- Trial name
- NCT02959866
- Testing
- online income tool
- Where
- 2 sites in Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Heart Failure
Comparison of BNP and NT-proBNP in the Management of Patients With Chronic and Acute Heart Failure
The purpose of this study is to compare the changes in B-type Natriuretic Peptide (BNP) and amino-terminal fragment of proBNP (NT-proBNP) in outpatients managed in the heart failure (HF) clinic initiated on the Angiotensin…
- Trial name
- NCT04107220
- Testing
- Sacubitril/Valsartan
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Unity Health Toronto
Glaucoma, Open-Angle
Saccadic Eye Movements Are Impaired In Glaucoma
The purpose of this study is to determine whether rapid eye movements called saccades are impaired in glaucoma, a neurodegenerative disease of visual pathways.
- Trial name
- NCT01254058
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Cytokine Levels in Patients With Persistent Diabetic Macular Edema Treated With Triamcinolone Acetonide
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02221453
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Diabetic Macular Edema
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02441907
- Testing
- aflibercept
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Unity Health Toronto
Rhegmatogenous Retinal Detachment
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment
The purpose of this research study is to compare the outcomes of pneumatic retinopexy with the outcomes of vitrectomy (with or without scleral buckle) for the management of retinal detachment, in terms of anatomical success…
- Trial name
- NCT01639209
- Testing
- Vitrectomy, Pneumatic retinopexy
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- Unity Health Toronto
Cervical Radiculopathy, Cervical Myelopathy
The Collar Post Anterior Cervical Spine Surgery Study
The Anterior Cervical Discectomy and Fusion (ACDF) represents one of the most commonly performed spinal operations internationally, often in the context of symptomatic radiculopathy or myelopathy secondary to cervical…
- Trial name
- C-PASS (NCT03842072)
- Testing
- Cervical collar
- Where
- 2 sites in Canada
- Volunteers
- 244 people
- Sponsor
- Unity Health Toronto
Asthma
The Electronic Asthma Action Plan System for Implementation in Primary Care
Asthma is a common and potentially fatal chronic disease. An asthma action plan (AAP) is a written plan produced by a physician for a patient with asthma, to provide education and guidelines for self-management of worsening…
- Trial name
- eAAPS (NCT01070095)
- Testing
- Electronic Asthma Action Plan System
- Where
- 3 sites in Canada
- Volunteers
- 19 people
- Sponsor
- Unity Health Toronto
Acute Graft Rejection, Renal Failure Chronic Requiring Dialysis
Kidney Transplant Failure
Primary Hypotheses: 1. Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have more deaths than patients who discontinue these drugs 2.
- Trial name
- NCT01296061
- Where
- Canada
- Volunteers
- 270 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Otitis Media, URTI
Xylitol for the Prevention of Acute Otitis Media Episodes in Children
This is a randomized controlled trial of regular daily use of xylitol (or "birch sugar"), a natural sweetener that has antimicrobial properties, for the prevention of acute otitis media (AOM, primary outcome) as well as upper…
- Conditions
- Acute Otitis Media, URTI, Dental Caries in Children
- Trial name
- POME-Xylitol (NCT03055091)
- Testing
- Xylitol syrup
- Where
- 2 sites in Canada
- Volunteers
- 472 people
- Sponsor
- Unity Health Toronto
Formularies
Differences Between Essential Medicines Lists in 135 Countries and Model List of Essential Medicines
The World Health Organization (WHO) has developed a model list of more than 400 medicines and recommends that each country adapt the list to its own circumstances. More than 100 countries have developed essential medicines lists.
- Trial name
- NCT03218189
- Testing
- Country characteristics
- Where
- Canada
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Rhegmatogenous Retinal Detachment
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment in Patients With Extended Criteria
Objective: To compare outcomes of retinal detachment repair following pneumatic retinopexy (PnR) versus pars plana vitrectomy in terms of anatomical success, functional success and patient quality of life in patients with…
- Trial name
- NCT02871531
- Testing
- Pneumatic retinopexy, Vitrectomy
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Cardiovascular Risk Factor
An Urban Trail Network and Cardiovascular Disease: A Natural Experiment
Associations between the built environment and health behaviours are robust, however (1) it remains unclear if the behaviours they elicit lead to meaningful improvements in health outcomes, at the population level and (2) little…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Diabetes Mellitus
- Trial name
- NCT04057417
- Testing
- Urban Trail
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Manitoba