Clinical trials: Phase 4, open to volunteers
Atrial Fibrillation (AF), Coronary Arterial Disease (CAD)
Net Clinical Benefit of Edoxaban Versus Apixaban in Patients With Atrial Fibrillation and Coronary Artery Disease
Non-vitamin K antagonist oral anticoagulants(NOACs) are standard care for thromboembolism prevention in patients with Aterial Fibrillation(AF).
- Trial name
- SMARTDECISION3 (NCT07753200)
- Testing
- Edoxaban, Apixaban
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Peripartum Cardiomyopathy, Postpartum
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and…
- Trial name
- REBIRTH (NCT05180773)
- Testing
- Bromocriptine, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban
- Where
- 64 sites in United States
- Volunteers
- 250 people
- Sponsor
- Dennis M. McNamara, MD, MS
Acute Heart Failure
Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure
FACILITATE-HF is a multicenter, randomized, double-blind, placebo-controlled trial designed to determine whether initiation of finerenone during the early phase of hospitalization has beneficial effects in patients with AHF who…
- Trial name
- FACILITATE-HF (NCT07397650)
- Testing
- Finerenone Oral Tablet
- Where
- 21 sites in Japan
- Volunteers
- 550 people
- Sponsor
- Juntendo University
Urinary Tract Infection
Topical Steroids to Prevent Recurrent Urinary Tract Infections in Uncircumcised Male Infants: a Pilot Study
The goal of this smaller clinical trial is to evaluate the study design of this research to help prepare for a larger research study in the future.
- Trial name
- STRUMI-T (NCT07508124)
- Testing
- betamethasone valerate 0.1% cream
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Neurodegenerative Diseases, Parkinson Disease
Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases
It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group.
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease Psychosis
- Trial name
- NCT05357612
- Testing
- Pimavanserin
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postoperative Pain After Spinal Surgery
Compined Lumber Longissimus Plane Block and Multifidus Longissimus Plane Block Versus Infiltration Field Block in Lumber Spine Surgery
Lumbar spine surgery is one of the most commonly performed procedures for degenerative spinal disorders, including lumbar disc herniation, spinal stenosis, and degenerative disc disease.
- Trial name
- LLP/MLP (NCT07681648)
- Testing
- Ultrasound-Guided Bilateral Combined LLP and MLP Block, [Ultrasound-Guided Bilateral Combined LLP and MLP Block], [Conventional Wound Infiltration with Bupivacaine]
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Engy Emil
Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence
Ezetimibe for Arrhythmia Recurrence After AF Ablation
This single-center, prospective, single-blind randomized controlled pilot trial aims to explore whether oral ezetimibe can reduce the 6-month recurrence rate of atrial tachyarrhythmia after catheter ablation in patients with…
- Trial name
- EAFA (NCT07752758)
- Testing
- Ezetimibe, Standardized post-ablation clinical management
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rheumatoid Arthritis (RA
JAK Inhibitor Dose TAPering Strategy Study
This study aims to assess the feasibility of tapering JAK inhibitors in rheumatoid arthritis patients in low disease activity by comparing a group of patients tapering the JAK inhibitor dosage to a group of patients continuing…
- Trial name
- JAK-TAP (NCT06687551)
- Testing
- Baricitinib (LY3009104) 4 mg, filgotinib 200mg/day, Tofacitinib 5 mg twice daily
- Where
- 24 sites in France
- Volunteers
- 308 people
- Sponsor
- University Hospital, Toulouse
Thyroidectomy, Cervical Plexus Block
The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy
Total thyroidectomy triggers a systemic surgical stress response involving neuroendocrine and inflammatory pathways. Ultrasound-guided bilateral intermediate cervical plexus block (BICPB) is commonly utilized for postoperative…
- Conditions
- Thyroidectomy, Cervical Plexus Block, Surgical Stress Response
- Trial name
- NCT07740460
- Testing
- Ultrasound-Guided Bilateral Intermediate Cervical Plexus Block Using 0,25% Levobupivacaine
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
Diabetic Macular Edema
South Asian Patients With Diabetic Macular Oedema Treated With Faricimab Assessing the Efficacy, Durability, and Safety (SEAFAR Study)
The YOSEMITE and RHINE trials, which studied DMO treated with faricimab, had a majority Caucasian cohort, and the small Asian cohort was East Asian, with no South Asian representation.
- Trial name
- SEAFAR (NCT07753616)
- Testing
- Intravitreal anti-VEGF injection, Faricimab
- Volunteers
- 120 people
- Sponsor
- Birmingham and Midland Eye Centre Sandwell and west Birmingham NHS trust
COVID-19 Vaccines
A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age
The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age.
- Trial name
- NCT07730450
- Testing
- BNT162b2 Vaccine, Tdap Vaccine
- Where
- 5 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Opioid Use Disorder
Assessing Optimal XRB Initiation Points in Jail
This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial…
- Trial name
- NCT06051890
- Testing
- Extended-Release Buprenorphine (XRB), Sublingual Buprenorphine (SLB)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Viral Wart, Plantar Wart
Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir
The goal of this clinical trial is to learn if injecting acyclovir (an antiviral drug) or vitamin D3 directly into skin warts works to clear them in people aged 12 and older with common, plantar, flat, or periungual (around the…
- Conditions
- Viral Wart, Plantar Wart, Common Warts (Verruca Vulgaris), Common Wart
- Trial name
- NCT07448844
- Testing
- Intralesional Acyclovir, Intralesional Vitamin D3
- Where
- 2 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
HELICOBACTER PYLORI INFECTIONS
Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression
Background: Helicobacter pylori (H. pylori) infection affects approximately 50% of the global population and is closely associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Eradication of H.
- Trial name
- NCT07750938
- Testing
- Keverprazan Hydrochloride 20 mg TID, Minocycline 100 mg (10-Day Regimen), Keverprazan Hydrochloride 20 mg BID
- Volunteers
- 316 people
- Sponsor
- Qilu Hospital of Shandong University
Asthma
Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
Single center, randomized, placebo- controlled study to assess change in mucociliary clearance of moderate to severe asthma patients after treatment with dupilumab or placebo.
- Trial name
- NCT04743791
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sally E. Wenzel MD
COPD (Chronic Obstructive Pulmonary Disease)
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests.
- Trial name
- ADORE (NCT07749001)
- Testing
- Mepolizumab 100 MG Injection
- Volunteers
- 36 people
- Sponsor
- Western University, Canada
Tissue Plasminogen Activator, Intraventricular Brain Hemorrhage
CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance
The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone.
- Trial name
- NCT07643493
- Testing
- Tissue Plasminogen Activator (tPA), Isotonic solution
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- David Dornbos
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Venous Leg Ulcer (VLU)
Nonhealing Venous Leg Ulcers Treated With a Standard of Care (SoC) Alone or Standard of Care and Dehydrated Human Placenta Tissue (dHPT) With Crossover
The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure of venous leg ulcers.
- Trial name
- EVOLVE (NCT07230340)
- Testing
- Amnion-Intermediate-Chorion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Cellution Biologics
Epidermolysis Bullosa (EB), Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Phase 4 Master Protocol for Patients Prescribed Prademagene Zamikeracel for the Treatment of Wounds
The Master Protocol includes 3 studies (Study A, Study B, and Study C) that will evaluate pz-cel and related processes in the post-marketing setting.
- Conditions
- Epidermolysis Bullosa (EB), Recessive Dystrophic Epidermolysis Bullosa (RDEB), Dystrophic Epidermolysis Bullosa (DEB)
- Trial name
- NCT07717736
- Testing
- Non-conforming pz-cel surgical application to RDEB wounds, Additional biopsies, Pz-cel surgical application to DEB wounds
- Volunteers
- 100 people
- Sponsor
- Abeona Therapeutics, Inc
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