Clinical trials: sponsored by Unity Health Toronto
Acute Otitis Media, URTI
Xylitol for the Prevention of Acute Otitis Media Episodes in Children
This is a randomized controlled trial of regular daily use of xylitol (or "birch sugar"), a natural sweetener that has antimicrobial properties, for the prevention of acute otitis media (AOM, primary outcome) as well as upper…
- Conditions
- Acute Otitis Media, URTI, Dental Caries in Children
- Trial name
- POME-Xylitol (NCT03055091)
- Testing
- Xylitol syrup
- Where
- 2 sites in Canada
- Volunteers
- 472 people
- Sponsor
- Unity Health Toronto
Rhegmatogenous Retinal Detachment
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment in Patients With Extended Criteria
Objective: To compare outcomes of retinal detachment repair following pneumatic retinopexy (PnR) versus pars plana vitrectomy in terms of anatomical success, functional success and patient quality of life in patients with…
- Trial name
- NCT02871531
- Testing
- Pneumatic retinopexy, Vitrectomy
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Cardiovascular Risk Factor
An Urban Trail Network and Cardiovascular Disease: A Natural Experiment
Associations between the built environment and health behaviours are robust, however (1) it remains unclear if the behaviours they elicit lead to meaningful improvements in health outcomes, at the population level and (2) little…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Diabetes Mellitus
- Trial name
- NCT04057417
- Testing
- Urban Trail
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Laparoscopic Roux-en-y Gastric Bypass
The BlackBox Study
This is a hypothesis generating pilot study to compare the impact of 2D versus 3D visualization on surgical performance, as measured by the OR BlackBox platform, during laparoscopic bariatric surgery.
- Trial name
- NCT03252470
- Testing
- Laparoscopic Roux-en-y Gastric Bypass Surgery
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Olympus Corporation of the Americas
Major Depressive Disorder, Cognitive Impairment
Modafinil's Effects on Cognition in Remitted MDD
Cognitive difficulties such as indecisiveness or inability to concentrate are core symptoms of depression with up to 90% of untreated depressed individuals experiencing these symptoms.
- Trial name
- NCT03620253
- Testing
- Modafinil
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Multiple Sclerosis
Decision Making in Multiple Sclerosis Care Under Uncertainty
The main objectives of this study are: i) To determine patient-level, physician-level and health system factors influencing therapeutic decisions in multiple sclerosis (MS) care by applying conjoint discrete experiments.
- Trial name
- NCT04035720
- Testing
- Quantitative risk
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- Unity Health Toronto
Cardiopulmonary Resuscitation
Three Different Cardiopulmonary Resuscitation (CPR) Training Methods
The goal of this study is to compare three methods of teaching medical and nursing students basic life saving skills. The standard method will teach students how to push on the chest and to analyze the heart rhythm using a…
- Trial name
- BLSPilot (NCT01361919)
- Testing
- Feedback During CPR Training and Testing, No Feedback Group, Feedback during CPR Training Not Testing
- Where
- Canada
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Arthroplasty, Replacement, Hip
Assessing the Wear Rates of the ADM/MDM Hips Using 3D X-ray Analysis
A common complication post hip replacement is hip dislocation or hip instability which can lead to the hip implants being revised.
- Trial name
- NCT04019925
- Testing
- ADM/MDM hip
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Respiratory Tract Infections, Asthma
DO IT Trial: Vitamin D Outcomes and Interventions In Toddlers
Vitamin D can be made in the skin by exposure to sunlight and can be found in certain foods. Vitamin D levels are alarmingly low in many North American children. Several health issues have been linked with low vitamin D.
- Conditions
- Respiratory Tract Infections, Asthma, Avitaminosis
- Trial name
- DO IT (NCT01419262)
- Testing
- Vitamin D - Cholecalciferol 400 IU, Vitamin D3 - Cholecalciferol 2000 IU
- Where
- 2 sites in Canada
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Ocular Melanoma
The Role of Inflammation in Ocular Tumours
This prospective, non-therapeutic study will determine whether a novel imaging technique can identify presumptive tumour associated macrophages (TAMs) in patients with ocular tumours. The investigators will evaluate 5 groups: 1.
- Trial name
- NCT02909517
- Testing
- cSLO imaging
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Age-Related Macular Degeneration
The Role of Inflammation in AMD and Related Disorders
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
- Trial name
- NCT02588378
- Testing
- multi-modal cSLO imaging
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Coronary Syndrome
Evaluation of Varenicline (Champix) in Smoking Cessation for Patients Post-Acute Coronary Syndrome (EVITA) Trial
The EVITA study is a clinical trial that will test the effect of varenicline (Champix™), a new drug used to help people quit smoking, in patients who have suffered a heart attack.
- Trial name
- EVITA (NCT00794573)
- Testing
- varenicline
- Where
- 4 sites in Canada
- Volunteers
- 302 people
- Sponsor
- Mark Eisenberg
Headache Disorders, Post-Concussion Syndrome
Can Targeted Education Impact the Current Standard of Care in Patients With Mild Traumatic Brain Injury?
The study will ask the question as to whether or not it is possible to deliver education material to patients with a mild traumatic brain injury in a consistent matter.
- Conditions
- Headache Disorders, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT03391583
- Testing
- Education
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
HIV/AIDS
Decision Support Intervention Adapted for HIV Pre-Exposure Prophylaxis for Adoption and Adherence for Black Canadians
Aim 1: Adapt Ottawa Decision Support Framework for the HIV PrEP decisional needs of African, Caribbean and Black (ACB) Canadian patients Aim 2.
- Trial name
- PrEPDSA (NCT03637244)
- Testing
- Decision Support Aid and PrEP for Black Canadians
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV, Post Traumatic Stress Disorder
Accelerated Resolution Therapy for HIV Positive African, Caribbean and Black
Nearly two-thirds of ACB people living in Ontario are classified as immigrant, refugee or undocumented [non-status/NS] (IRNS) individuals.
- Trial name
- NCT03649607
- Testing
- Accelerated Resolution Therapy
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus (DM), Congestive Heart Failure (CHF)
Expanding Paramedicine in the Community
Initiatives aimed at reducing Emergency Department (ED) wait times and improved community health initiatives are major priorities in Canada.
- Conditions
- Diabetes Mellitus (DM), Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- EPIC (NCT02034045)
- Testing
- Community Paramedicine, Usual Care
- Where
- 4 sites in Canada
- Volunteers
- 467 people
- Sponsor
- Unity Health Toronto
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Primary Anterior Shoulder Dislocation
A Randomized Evaluation of Emergent Immobilization in External Rotation in the Management of Acute Anterior Dislocations of the Shoulder
Shoulder dislocations are quite common, the prevalence over a lifetime being estimated at 2% in the general population. In young patients, recurrence after a primary dislocation is also common (~60%) and multiple recurrent…
- Trial name
- EERAADS (NCT02197819)
- Testing
- Sling, External Rotation Brace
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Clinical Decision-making
Review and Assessment of Network Meta-analyses for Knowledge Uptake Study
This randomized controlled trial will assess the interpretability of the rank-heat plot for presenting the results of network meta-analysis in comparison to SUCRA (surface under the cumulative ranking) plots which are suggested…
- Trial name
- RANK (NCT03283592)
- Testing
- Rank-Heat Plot, SUCRA Plot
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Arthroplasty Complications, Hip Arthritis
An Assessment of 4 Different Bearing Types in Hip Replacement Types to Analsye the Lowest Wear Rates of Polyethylene
The aim of the study is to assess the ideal bearing surfaces in hip replacement by comparing 4 different combinations. In a hip replacement this means what the head and the socket liner are made of.
- Trial name
- NCT03900039
- Testing
- Highly Cross Linked Polyethylene and oxidized zirconium femoral head
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto