Clinical trials: sponsored by Aarhus University Hospital
Psoriasis Vulgaris, Psoriasis
Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study
Psoriasis is a non-communicable chronic immune-mediated disease. Psoriatic skin is characterized by excessive proliferation of skin cells and infiltration of immune cells. The cause of psoriasis is so far unknown.
- Conditions
- Psoriasis Vulgaris, Psoriasis, Skin Diseases, Skin Diseases, Papulosquamous
- Trial name
- MEMPSOLAR (NCT05185258)
- Testing
- Enstilar
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Oncology, Infections
A Comparison of Static and Dynamic PET/CT (HYPOTHESIS Generation Study)
The general purpose of this initial study is to evaluate whether parametric PET/CT improves diagnosis and treatment monitoring in select diseases. The specific aim of the HYPOTHESIS GENERATION study is: 1.
- Conditions
- Oncology, Infections, Inflammation
- Trial name
- NCT05110443
- Testing
- D-WB PET/CT
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Endothelial Dystrophy, Secondary Bullous Keratopathy
Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation
After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. However, the optimal postoperative treatment regimen is unknown.
- Conditions
- Endothelial Dystrophy, Secondary Bullous Keratopathy, Posterior Lamellar Keratoplasty, Descemet's Stripping Endothelial Keratoplasty
- Trial name
- NCT01682421
- Testing
- Weak steroid (Flurolon, Allergan), Potent steroid (Maxidex, Alcon)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Astigmatism
Surgical Correction of Astigmatism
Laser correction for myopia and astigmatism using an excimer laser has been performed with success for several years. During the last 2 years, a new method for correction of refractive errors has emerged.
- Trial name
- NCT01680354
- Testing
- ReLEx, LASIK
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Myopia
Wavefront-guided LASIK for Correction of Myopia
Laser in situ keratomileusis is a successful procedure for the treatment of low to moderate myopia. Advances over the last decade have allowed LASIK to also correct higher order wavefront aberrations.
- Trial name
- NCT01682434
- Testing
- Laser in situ keratomileusis (LASIK)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Type 1
INfluenza VaccInation To Mitigate typE 1 Diabetes
In a multicenter, prospective, randomized, controlled clinical trial to compare influenza vaccination and placebo in sustaining β cell function in early type 1 diabetes mellitus.
- Trial name
- INVITED (NCT05585983)
- Testing
- Vaxigrip Tetra Sanofi Pasteur Europe
- Where
- 10 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Peanut Allergic Subjects, Peanut Allergies
Oral Immunotherapy for Children With Peanut Allergy
This clinical trial aims to investigate if oral immunotherapy can help children with peanut allergy tolerate peanut. Children aged 6 months to 4 years can take part in the trial.
- Conditions
- Peanut Allergic Subjects, Peanut Allergies, Peanut Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07895095
- Testing
- Oral immunotherapy with peanut
- Where
- 5 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Laura Ozer Kettner
Small Bowel Adenocarcinoma
Molecularly Redefining Small Bowel Adenocarcinoma to Accelerate Precision Patient Care
Small bowel adenocarcinoma is a rare malignancy, and there is limited knowledge about its optimal clinical management and molecular background.
- Trial name
- SBAMOL (NCT06234306)
- Where
- 3 sites in Denmark
- Volunteers
- 500 people
- Sponsor
- Copenhagen University Hospital at Herlev
Lung Cancer (NSCLC)
Sublobar Wedge Resection or Stereotactic Radiotherapy Treatment of High-risk Patients With Early-stage Lung Cancer
In low-risk patients with stage I non-small cell lung cancer (NSCLC) surgical treatment with an anatomical resection is currently the standard of care.
- Trial name
- STRADOS (NCT07432802)
- Testing
- Stereotactic radiation therapy intervention, Surgical intervention
- Where
- 4 sites in Denmark
- Volunteers
- 182 people
- Sponsor
- Aarhus University Hospital
Acute Myocardial Infarction
The SORT OUT IX STEMI OCT Trial
The aim of the Danish Organization for Randomized Trials with Clinical Outcome (SORT OUT) IX STEMI OCT is to compare early vascular healing of the polymer-free Biolimus-eluting BIOFREEDOM stent with a biodegradable-polymer…
- Trial name
- OCT STEMI SOIX (NCT02915107)
- Testing
- BioFreedom, Orsiro
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Odense University Hospital
Ischaemic Heart Disease
BIOFREEDOM Stent Versus ORSIRO Stent: SORT OUT IX
The aim of the Danish Organization for Randomized Trials with Clinical Outcome (SORT OUT) is to compare the safety and efficacy of the polymer-free Biolimus-eluting BIOFREEDOM stent with a biodegradable-polymer Sirolimus-eluting…
- Trial name
- SORT OUT IX (NCT02623140)
- Testing
- Biofreedom, Orsiro
- Where
- Denmark
- Volunteers
- 3,150 people
- Sponsor
- Odense University Hospital
Egg Allergy, Egg Hypersensitivity
Oral Immunotherapy for Children With Egg Allergy
This clinical trial aims to investigate if oral immunotherapy can help children with egg allergy tolerate eggs. Children aged 6-18 months can take part in the trial.
- Conditions
- Egg Allergy, Egg Hypersensitivity, Food Allergy in Children, Food Allergies
- Trial name
- NCT07888439
- Testing
- Oral immunotherapy with egg
- Where
- 5 sites in Denmark
- Volunteers
- 76 people
- Sponsor
- Laura Ozer Kettner
Cardiotoxicity, HER2-positive Breast Cancer
Imaging Versus Cardiac Biomarker Monitored HER2 Directed Therapy in Patients With Breast Cancer
Due to a risk of heart failure during HER2 directed therapy in breast cancer, treatment is monitored with imaging of myocardial function, which is resource demanding for both patients and the health care system.
- Trial name
- HER2BIC (NCT05406635)
- Testing
- Biomarkers: Troponins and natriuretic peptides
- Where
- 3 sites in Denmark
- Volunteers
- 191 people
- Sponsor
- Odense University Hospital
Laparotomy, Bowel Obstruction
Early vs Postponed Parenteral Nutrition After Emergency Abdominal Surgery
The aim of this study is to investigate the effect of early, supplementary parenteral nutrition following emergency laparotomy. Currently, parenteral nutrition is used in postoperative patients if or when oral or enteral…
- Conditions
- Laparotomy, Bowel Obstruction, Ischemia, Mesenteric
- Trial name
- EATERS (NCT06089551)
- Testing
- SmofKabiven
- Where
- Denmark
- Volunteers
- 342 people
- Sponsor
- Copenhagen University Hospital at Herlev
Heart Transplantation
Donor Derived Cell Free DNA (Dd-cfDNA) as a Biomarker for Allograft Rejection in Heart Transplant Recipients
Following heart transplantation (HTx), lifelong immunosuppressive treatment is required to prevent the immune system from attacking, damaging, and rejecting the donor hear (allograft).
- Trial name
- TRANSCEND (NCT07886489)
- Testing
- Donor-derived cell free DNA
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Atrial Fibrillation, Left Atrial Appendage Absent
Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)
Left atrial appendage (LAA) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Absent, Anticoagulant Adverse Reaction
- Trial name
- NCT06401616
- Testing
- OAC will be discontinued for the duration of the trial
- Where
- 6 sites in Denmark
- Volunteers
- 1,220 people
- Sponsor
- Odense University Hospital
Pregnancy, Obesity
When to INDuce for OverWeight? (WINDOW)
The rate of overweight and obese women becoming pregnant is increasing. Obesity in pregnancy along with delivery by cesarean section in obese women is associated with several complications as compared to normal weight women.
- Conditions
- Pregnancy, Obesity, Parturition
- Trial name
- WINDOW (NCT04603859)
- Testing
- Elective induction of labor at 39 gestational weeks and 0 to 3 days
- Where
- 12 sites in Denmark
- Volunteers
- 1,901 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Kidney Transplant Infection, Bloodstream Infection
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation
Kidney transplant recipients take medicines that suppress the immune system to prevent rejection of the transplanted kidney. As a result, they have a high risk of infections, especially urinary tract infections (UTIs).
- Conditions
- Kidney Transplant Infection, Bloodstream Infection, Kidney Transplant, Kidney Transplant Recipients
- Trial name
- PREDICT (NCT07407673)
- Testing
- Pivmecillinam
- Where
- 3 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Susanne Dam Nielsen, MD, DMSc
Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis
Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction
A multi-center double-blinded placebo-controlled randomized clinical trial. The patients will be randomized into two groups. To investigate the efficacy of SNM to improve the key bladder diary variables compared to placebo (i.e.
- Conditions
- Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis, Sacral Neuromodulation, Bowel Dysfunction
- Trial name
- NCT05380856
- Testing
- Turning ON the neuromodulator, Turning OFF the neuromodulator
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
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