Clinical trials: sponsored by Aarhus University Hospital
Head and Neck Cancer (H&N), Thyroid Cancer
Head and Neck Cancer Strategies
The overall aim is to investigate whether genetic and other molecular markers can improve the diagnosis, assessment of treatment response, and detection of recurrence in patients with head and neck cancer.
- Trial name
- NCT07909603
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Aarhus University Hospital
Breast Cancer (Early Breast Cancer), Obesity
Semaglutide for Weight Management During Hormone Therapy for Early Breast Cancer
This study will assess whether women with obesity and early estrogen receptor-positive breast cancer can complete 26 weeks of semaglutide treatment while continuing their prescribed hormone therapy for breast cancer.
- Trial name
- WISPER (NCT07909889)
- Testing
- Semaglutide (Wegovy®)
- Where
- 2 sites in Denmark
- Volunteers
- 32 people
- Sponsor
- Aarhus University Hospital
Achilles Tendon Rupture
Blood Flow Restriction Exercise in Patients With an Achilles Tendon Rupture
The goal of this clinical trial is to gain insights into the effects of Blood Flow Restriction Exercise (BFRE) in patients with an acute Achilles tendon Rupture.
- Trial name
- BEAN (NCT06434272)
- Testing
- Early exercise with partial Blood Flow Restriction, Late exercise with partial Blood Flow Restriction
- Where
- Denmark
- Volunteers
- 218 people
- Sponsor
- University of Aarhus
Ischemic Heart Disease, Ischemic Coronary Artery Disease
Optical Coherence Tomography in Acute Vessel Evaluation
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
- Conditions
- Ischemic Heart Disease, Ischemic Coronary Artery Disease, ACS (Acute Coronary Syndrome)
- Trial name
- OCTAVE (NCT07422688)
- Testing
- Angiographic Guided PCI, OCT Guided PCI
- Where
- 28 sites in Belgium, Denmark and 10 more
- Volunteers
- 3,000 people
- Sponsor
- Aarhus University Hospital Skejby
Pediatric Cancer, Cognitive Dysfunction
Engaging Parents in Neuropsychological Rehabilitation for Childhood Cancer Survivors: The ImPACT Program - A Pilot Study
The aim of the present pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of a novel, context-sensitive neuropsychological rehabilitation intervention for childhood cancer survivors and their…
- Trial name
- NCT05483166
- Testing
- ImPACT
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Medial Patellofemoral Dislocation, Medial Patellofemoral Ligament Reconstruction
Medial Patellofemoral Ligament Reconstruction in Children - a 2-8 Years Follow-up Study
The purpose of this project is to investigate the treatment outcome after MPFL reconstruction in children as a treatment for chronic patellar instability, where the superficial part of the quadriceps tendon is fixed to the femur…
- Trial name
- MPFL (NCT06257836)
- Testing
- MPFL-reconstruction
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Type 1
INfluenza VaccInation To Mitigate typE 1 Diabetes
In a multicenter, prospective, randomized, controlled clinical trial to compare influenza vaccination and placebo in sustaining β cell function in early type 1 diabetes mellitus.
- Trial name
- INVITED (NCT05585983)
- Testing
- Vaxigrip Tetra Sanofi Pasteur Europe
- Where
- 10 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Endothelial Dystrophy, Secondary Bullous Keratopathy
Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation
After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. However, the optimal postoperative treatment regimen is unknown.
- Conditions
- Endothelial Dystrophy, Secondary Bullous Keratopathy, Posterior Lamellar Keratoplasty, Descemet's Stripping Endothelial Keratoplasty
- Trial name
- NCT01682421
- Testing
- Weak steroid (Flurolon, Allergan), Potent steroid (Maxidex, Alcon)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Patellar Dislocation
Comparison of Two Graft Choices in Mediale Patellofemoral Ligament Reconstruction (MPFL)
The purpose of this study is to elucidate surgical techniques for reconstructing MPFL in the treatment of chronic patella instability.
- Trial name
- NCT05706363
- Testing
- Quadriceps graft
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Astigmatism
Surgical Correction of Astigmatism
Laser correction for myopia and astigmatism using an excimer laser has been performed with success for several years. During the last 2 years, a new method for correction of refractive errors has emerged.
- Trial name
- NCT01680354
- Testing
- ReLEx, LASIK
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Keratitis
Evaluation of Next-Generation Sequencing-based Metabarcoding Versus Culturing for Microbiological Assessment in Infectious Keratitis
Infectious keratitis is a potential sight threatening condition. In conventional clinical practice culturing is performed in order to identify the causative microbial organism; however in recent years Next Generation Sequencing…
- Trial name
- NCT05183906
- Testing
- Next generation sequencing
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- Aarhus University Hospital
Oncology, Infections
A Comparison of Static and Dynamic PET/CT (HYPOTHESIS Generation Study)
The general purpose of this initial study is to evaluate whether parametric PET/CT improves diagnosis and treatment monitoring in select diseases. The specific aim of the HYPOTHESIS GENERATION study is: 1.
- Conditions
- Oncology, Infections, Inflammation
- Trial name
- NCT05110443
- Testing
- D-WB PET/CT
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Baker's Cyst
Focused Ultrasound of the Popliteal Fossa for Detection of Symptomatic Baker's Cysts in Patients With Suspected Deep Vein Thrombosis: A Pilot Diagnostic Accuracy Study
Quality improvement study with prospective observational design. The study explores the feasibility of testing diagnostic accuracy of an emergency department-performed focused ultrasound scan of the popliteal fossa in detecting…
- Trial name
- BAKER-DVT (NCT07791017)
- Testing
- Index Test (Focused Ultrasound of the Popliteal Fossa), Reference test (Routine DVT Diagnostic Pathway)
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Aarhus University Hospital
Psoriasis Vulgaris, Psoriasis
Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study
Psoriasis is a non-communicable chronic immune-mediated disease. Psoriatic skin is characterized by excessive proliferation of skin cells and infiltration of immune cells. The cause of psoriasis is so far unknown.
- Conditions
- Psoriasis Vulgaris, Psoriasis, Skin Diseases, Skin Diseases, Papulosquamous
- Trial name
- MEMPSOLAR (NCT05185258)
- Testing
- Enstilar
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Myopia
Wavefront-guided LASIK for Correction of Myopia
Laser in situ keratomileusis is a successful procedure for the treatment of low to moderate myopia. Advances over the last decade have allowed LASIK to also correct higher order wavefront aberrations.
- Trial name
- NCT01682434
- Testing
- Laser in situ keratomileusis (LASIK)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Acute Tonsillitis, Peritonsillar Abscess
A Single Dose of Intravenous Penicillin as an Adjunct to Oral Penicillin in the Treatment of Acute Tonsillitis, Peritonsillar Phlegmon, and Peritonsillar Abscess
Background Tonsillar infections are highly prevalent and are associated with substantial morbidity, including severe sore throat, dysphagia, and general malaise.
- Conditions
- Acute Tonsillitis, Peritonsillar Abscess, Peritonsillar Cellulitis
- Trial name
- EGO PEN (NCT07896226)
- Testing
- Benzylpenicillin
- Where
- Denmark
- Volunteers
- 154 people
- Sponsor
- Tejs Ehlers Klug
Peanut Allergic Subjects, Peanut Allergies
Oral Immunotherapy for Children With Peanut Allergy
This clinical trial aims to investigate if oral immunotherapy can help children with peanut allergy tolerate peanut. Children aged 6 months to 4 years can take part in the trial.
- Conditions
- Peanut Allergic Subjects, Peanut Allergies, Peanut Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07895095
- Testing
- Oral immunotherapy with peanut
- Where
- 5 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Laura Ozer Kettner
Surgical Wound Infection, Neck Infection
Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive Surgery
The goal of this study is to measure how well commonly used antibiotics reach the tissue in the head and neck region in adults with a postoperative neck infection or undergoing reconstructive nasal surgery with an inferior…
- Conditions
- Surgical Wound Infection, Neck Infection, Nasal Reconstruction
- Trial name
- ANTIBIOTIKA (NCT07896239)
- Testing
- Cefuroxime, Dicloxacillin, Cloxacillin
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Tejs Ehlers Klug
Small Bowel Adenocarcinoma
Molecularly Redefining Small Bowel Adenocarcinoma to Accelerate Precision Patient Care
Small bowel adenocarcinoma is a rare malignancy, and there is limited knowledge about its optimal clinical management and molecular background.
- Trial name
- SBAMOL (NCT06234306)
- Where
- 3 sites in Denmark
- Volunteers
- 500 people
- Sponsor
- Copenhagen University Hospital at Herlev
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