Clinical trials: sponsored by Beijing Tongren Hospital
Low Vision in Children
Research and Development of Reading Visual Aids for Low-Vision Individuals Based on Virtual Reality Technology
Low vision substantially impairs reading ability and educational participation in adolescents. Existing assistive technologies, including optical magnifiers and electronic visual aids, are often limited by fragmented system…
- Trial name
- NCT07703449
- Testing
- VR-Based Intelligent Reading Aid, Natural Vision Reading (No Assistive Device)
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Retinitis Pigmentosa
Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa
This project intends to transplant a clinical level human embryonic stem cells derived retinal pigment epithelium into subretinal space to treat eetinitis pigmentosa(RP) diseases.
- Trial name
- NCT03944239
- Testing
- Retinal pigment epitheliums transplantation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Qi Zhou
Dry Eye
Perfluorohexyloctane Eye Drops vs. Sodium Hyaluronate for Video Display Terminal-Associated Dry Eye
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of perfluorohexyloctane (PFHO) eye drops (Hengqin®, Chengdu Shengdi Pharmaceutical Co., Ltd.) compared with…
- Trial name
- NCT07679685
- Testing
- 0.1% Sodium Hyaluronate Eye Drops, Perfluorohexyloctane Eye Drops (PFHO)
- Where
- 9 sites in China
- Volunteers
- 159 people
- Sponsor
- Beijing Tongren Hospital
Diabetic Kidney Disease, Type 2 Diabetes
Development and Validation of a Machine Learning Model for Differentiating Diabetic Kidney Disease and Non-Diabetic Kidney Disease in Type 2 Diabetes
This multicenter retrospective observational study aims to develop and validate an interpretable machine learning model for differentiating diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) in patients with…
- Conditions
- Diabetic Kidney Disease, Type 2 Diabetes, Chronic Kidney Disease
- Trial name
- NCT07672639
- Where
- China
- Volunteers
- 2,201 people
- Sponsor
- Beijing Tongren Hospital
Bell's Palsy
Bell's Palsy With a Duration of Greater Than 8 Weeks Treated With Multiwave Locked System Intervention
OBJECTIVE: To determine whether photobiomodulation therapy by class IV Multiwave Locked System laser treatment could relieve symptoms in patients with Bell's palsy with a duration of greater than 8 weeks.
- Trial name
- NCT05846217
- Testing
- Multiwave Locked System
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tongren Hospital
Visual Fatigue, Dry Eye
Evaluation of New Color Temperature Adjustment Mode in Preventing Dry Eye and Visual Fatigue
The purpose of this study was to investigate the effects of visual fatigue and dry eye level under different correlated color temperature modes, and to evaluate the effect of new designed dynamic color temperature change modes on…
- Trial name
- NCT07201493
- Testing
- color temperature change mode
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
This is a single-center, randomized, double-blinded, placebo-controlled clinical trial in adults with moderate-to-severe chronic rhinosinusitis with nasal polyps (CRSwNP) who have no previous nasal surgery.
- Trial name
- NCT07616609
- Testing
- Stapokibart
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tongren Hospital
Immune Thrombocytopenia
ATRA for Management of Primary ITP
A multicenter, randomized, double-blind placebo-controlled study to report the efficacy and safety of all-trans etinoic acid compared to placebo for the treatment of adults with corticosteriod-resistant/relapsed primary immune…
- Trial name
- NCT07597395
- Testing
- all-trans retinoic acid (ATRA)
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Peking University People's Hospital
HNSCC
Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC
This is a single-arm, phase Ib study involving HNSCC patients who had received first-line treatment with either PD-1 combined with platinum-based drugs or PD-1 monotherapy.
- Trial name
- LONG'E (NCT07040072)
- Testing
- Stapokibart and Finotonlimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tongren Hospital
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Extranodal NK/T-cell Lymphoma
Selinexor Combined With Reduced-Dose Radiotherapy For Early-Stage Extranodal NK/T-Cell Lymphoma
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus-associated non-Hodgkin lymphoma with high incidence in Asia and Latin America.
- Trial name
- NCT07554482
- Testing
- Pegaspargase (PEG) Asparaginase, Gemcitabine (GEM), Oxaliplatin
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Beijing Tongren Hospital
Unknown Primary Tumors, DNA Methylation
PaCIFiC-CUP Classifies Cancer of Unknown Primary
This study aims to initially utilize machine learning on pan-cancer DNA methylation data from public databases to construct a DNA methylation classification model (PaCIFiC-CUP, pan-cancer integrated fingerprinting classifier of…
- Trial name
- NCT06140992
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Primary Central Nervous System Lymphoma (PCNSL), Diffuse Large B Cell Lymphoma (DLBCL)
Pomalidomide, Anti-PD-1 Antibody Combined With Selinexor (PPS) in Relapsed/Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma
Primary central nervous system diffuse large B-cell lymphoma (PCNSL-DLBCL) is a highly aggressive malignancy accounting for over 80% of primary CNS lymphomas, with an annual incidence of 0.4-0.6 per 100,000 people globally and a…
- Trial name
- NCT07523737
- Testing
- Pomalidomide, PD-1 / PD-L1 monoclonal antibody, XPO1 inhibitor
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Beijing Tongren Hospital
Extranodal NK T Cell Lymphoma, Hemophagocytic Lymphohistiocytosis (HLH)
Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)
Extranodal NK/T-cell lymphoma (NKTCL) is an aggressive EBV-associated lymphoma with poor prognosis, highly prevalent in China. Early-stage NKTCL achieves favorable long-term survival, while advanced disease shows dismal outcomes…
- Trial name
- NCT07525466
- Testing
- Mitoxantrone liposome, Etoposide, Pegaspargase (PEG) Asparaginase
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tongren Hospital
Neuromuscular Blocking Agents
Antagonism of Neostigmine in Continuous Infusion of Mivacurium
In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism…
- Trial name
- NCT07524959
- Testing
- Neostigmine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tongren Hospital
Cataract Senile
Evaluating App-Based Vision Testing (WHOeyes) Combined With the Questionnaire as a Substitute for One-Week Postoperative In-Clinic Follow-Up in Age-Related Cataract Patients: A Multi-center Randomized Controlled Trial
The goal of this clinical trial is to learn if an app-based vision testing (WHOeyes) combined with a questionnaire can recognize those who have to go back to the hospital, and thus replace the in-clinic 1-week review after an…
- Trial name
- NCT06429527
- Testing
- WHOeyes combined with a questionnaire.
- Where
- China
- Volunteers
- 334 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Emergence Agitation
Auricular Acupressure for Reducing Postoperative Emergence Agitation in Preschool Children
This study investigates whether auricular acupressure can reduce postoperative emergence agitation among preschool children following adenoidectomy.
- Trial name
- NCT07472764
- Testing
- Auricular acupressure
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tongren Hospital
NK T-Cell Lymphoma
Phaes Ⅱ Study of Golidocitinib-Pegaspargase-PD-1 Antibody First-Line for Advanced ENKTL
Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive non-Hodgkin lymphoma with poor prognosis in advanced stages, with a 5-year overall survival (OS) rate of less than 30% despite asparaginase-based regimens.
- Trial name
- NCT07457177
- Testing
- Golidocitinib + Pegaspargase + Anti-PD-1 mAb
- Volunteers
- 40 people
- Sponsor
- LIANG WANG
Marginal Zone Lymphoma
Exploratory Study of Orelabrutinib in the Treatment of Early-stage Untreated MZL
This is a single-arm, multicenter, prospective, phase II study. The primary objective is to assess the efficacy and safety of orelabrutinib in treatment-naïve patients with marginal zone lymphoma.
- Trial name
- MZL-IIT-O (NCT07441993)
- Testing
- Orelabrutinib
- Where
- 14 sites in China
- Volunteers
- 30 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Myopia
Evaluation of the Efficacy of Red Light in Adult Patients With High and Extreme Myopia
This study, led by Jie ying from the Ophthalmology Department of Beijing Tongren Hospital Affiliated to Capital Medical University, is a researcher-initiated clinical trial (IIT) designed to evaluate the therapeutic efficacy of…
- Trial name
- NCT07412678
- Testing
- Red light, Single vision spectacle lenses
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Beijing Tongren Hospital