Clinical trials: sponsored by University of Oklahoma
Endometrial Cancer
Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer
This is a single arm, Phase II study using the combination of atezolizumab and bevicacizumab in women with advanced, recurrent or persistent endometrial cancer.
- Trial name
- NCT03526432
- Testing
- Bevacizumab, Atezolizumab
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Oklahoma
Prostate Cancer, Renal Cell Carcinoma (RCC)
Characterizing the Genomic Landscape of Cancer in Native American Populations (NAT-Geno)
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prespecified cancers of interest.
- Trial name
- NCT06960798
- Testing
- Bio-specimen Collection, Blood Draw
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Cognitive Coping, Cancer
Evaluating Feasibility and Acceptability of Pain Education
The purpose of this study is to implement a healthy, non-invasive therapeutic alternative for managing cancer-related pain in chronic cancer patients (Cancer Pain 101).
- Trial name
- NCT07869420
- Testing
- Cancer Pain 101, Pharmacotherapy Informational Packet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Oklahoma
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Proton Therapy, Radiation Therapy, Secondary Skin Reactions
Protoacoustic Imaging For 3D Mapping
The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy.
- Conditions
- Proton Therapy, Radiation Therapy, Secondary Skin Reactions, Liver Cancer, Prostate Cancer
- Trial name
- NCT07832617
- Testing
- Radiacoustic Imaging w/Ultrasound.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Oklahoma
Breast Cancer
Biopsy-site-marker in Breast Cancer
The purpose of this study is to explore pro-metastatic changes in breast cancer (BC) associated with the stiffness of biopsy site markers.
- Trial name
- NCT07833566
- Testing
- Biopsy-Site Marker Placement.
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation
Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery.
- Trial name
- STOP_AF (NCT04514757)
- Testing
- active tVNS
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of California, Los Angeles
Communication Research, Communication Programs
The Fundamentals of Communication in Surgery
The goal of this observational study is to evaluate the impact of the FCS curriculum on achieving the learning objectives and resident reported self-efficacy with communication skills and determine the scalability of the training…
- Trial name
- FCS (NCT06654310)
- Testing
- Delivery of FCS Skills Curriculum
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Immune Checkpoint Inhibitors, Metastatic Solid Tumor
Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population
The aim of this study is to describe the outcomes in American Indian patients receiving immunotherapy in a multi-institution retrospective study at several other high-volume centers that care for this patient population and to…
- Conditions
- Immune Checkpoint Inhibitors, Metastatic Solid Tumor, Nonsmall Cell Lung Cancer, Melanoma
- Trial name
- NCT05863052
- Testing
- Immunotherapy
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Oklahoma
Glioblastoma
OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma
This is a pilot study exploring the potential benefit of adding OKN-007 with Temozolomide for treatment in patients with malignant Glioblastoma undergoing adjuvant concomitant radiotherapy.
- Trial name
- NCT03587038
- Testing
- OKN 007, Temozolomide, Photon/Proton IMRT
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Oklahoma
Cancer, Pain
Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment
This project will evaluate the feasibility and acceptability of Empowered Relief (ER) among American Indian adults who are currently receiving or have completed active cancer treatments at Stephenson Cancer Center (SCC).
- Conditions
- Cancer, Pain, Pain Management, Chronic Pain
- Trial name
- ejames3 (NCT07742449)
- Testing
- Empowered Relief
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Oklahoma
Risk Perceptions, Decision Making
Designing Effective Alcohol Health Warnings: An Experimental Study With Adults in the U.S.
Consuming alcohol is a dose-dependent and modifiable risk factor for breast cancer. Although alcohol consumption contributes to an estimated 16% of breast cancer cases, awareness of the link between alcohol and breast cancer risk…
- Conditions
- Risk Perceptions, Decision Making, Alcohol
- Trial name
- NCT07812545
- Testing
- Health warning statement evaluations (bottles), Health warning statement evaluations (ads)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Oklahoma
Obesity, Pregnancy
Maternal Obesity, Breast Milk Composition, and Infant Growth
Today the majority of pregnant women in the United States are either overweight or obese at conception with their offspring having greater adiposity at birth, a 2-fold greater risk of later obesity, and neonatal insulin…
- Conditions
- Obesity, Pregnancy, Breastmilk Collection, Infant Overnutrition
- Trial name
- (MILK) (NCT03301753)
- Where
- 2 sites in United States
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Neuropathy Ulnar
Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow
This research is studying two surgical procedures in a large group of people to learn about how well these procedures work as a treatment for ulnar neuropathy at the elbow (UNE).
- Trial name
- NCT04254185
- Testing
- Simple decompression, Subcutaneous anterior transposition
- Where
- 10 sites in United States
- Volunteers
- 378 people
- Sponsor
- University of Michigan
Paramedian Forehead Flap
Topical CBD Scar Healing Study
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
- Trial name
- NCT06129591
- Testing
- Vantage Hemp CBD Isolate + Silicone patch, Silicone patch
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Oklahoma
Colorectal Cancer (CRC)
Raising Awareness of Colorectal Screening in American Indian Communities
This study focuses exclusively on American Indian individuals within their communities to enhance health equity and address a critical tribal health priority.
- Trial name
- AIC-DC (NCT07515729)
- Testing
- Navigator-led intervention
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pregnancy
Therapeutic Omegas for Triglyceride Suppression
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood.
- Trial name
- TOTS (NCT04349475)
- Testing
- Intervention Omega 3 Supplementation
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smoking, Sleep Disturbance
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity.
- Conditions
- Smoking, Sleep Disturbance, Nicotine Dependence
- Trial name
- NCT03968900
- Testing
- Sleep restriction condition, Sleep extension condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Multiple Chronic Conditions, Disability Physical
Behavioral Activation + Occupational Therapy
Approximately 45% of older adults in the U.S. have 2 or more chronic health conditions (e.g., arthritis, hypertension, diabetes) in addition to functional limitations that prevent performance of health self-management activities.
- Trial name
- BA+OT (NCT05600465)
- Testing
- Behavioral Activation + Occupational Therapy, Enhanced Usual Care
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma