Clinical trials: sponsored by Xuanwu Hospital, Beijing
Blood Pressure Control, Hypertension
Direct Electrical Stimulation of Central Autonomic Network for Blood Pressure Control: a Mechanism Study
The primary objective of this research is to study direct electrical stimulation of central autonomic network for blood pressure control.
- Trial name
- NCT07844239
- Testing
- direct electrical stimulation
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Rehabilitation
Neuromodulation for Functional Recovery After Stroke
This study used a multicenter, double-blind, randomized controlled design. The trial protocol was jointly designed by the principal investigator and an executive committee composed of experts in functional neurosurgery…
- Conditions
- Stroke, Rehabilitation, Vagus Nerve Stimulations
- Trial name
- VNS-EARLY (NCT07841431)
- Testing
- active VNS (0.8 mA), Control VNS (0.0 mA)
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Frailty at Older Adults, Sarcopenia
A Clinical Study on the Improvement of Frailty and Sarcopenia in Elderly Community Residents Through Pulsed Electromagnetic Field Therapy
The entire clinical study will be conducted strictly following the following procedure: 1) Informed Consent If you decide to participate in this trial, we will first ensure that you fully understand the research purpose…
- Trial name
- NCT07834697
- Testing
- Standard treatment with pulsed magnetic therapy apparatus, Fake stimulation therapy with pulse magnetic therapy device
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurodegenerative Disease, Dementia
Cognition and Affective Research in China
This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive…
- Conditions
- Neurodegenerative Disease, Dementia, Alzheimer's Disease, Parkinson's Disease
- Trial name
- CARE (NCT07833267)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Femoropopliteal Occlusive Disease
The Efficacy of Endovascular Treatment in FPOD With TASC C and D Lesions
Based on the development of new tools, including drug coated balloon, paclitaxel eluting stent, interwoven stents, debulking tools, more challenging femoropopliteal arterial lesions have been treated with endovascular procedures.
- Trial name
- NCT04698304
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 1,518 people
- Sponsor
- RenJi Hospital
Subarachnoid Hemorrhage, Traumatic
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH).
- Trial name
- OSMO-SAH (NCT05858060)
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
The Effect of GD-iExo-003 in Acute Ischemic Stroke
This is a multicenter, randomized, double-blinded, placebo-controlled, dose-escalation trial. The objective of this study is evaluating safety and preliminary efficacy of intravenous exosomes derived from human induced…
- Trial name
- ExoCURE (NCT06138210)
- Testing
- exosomes derived from human induced pluripotent stem cell for injection
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Endarterectomy, Carotid Stenting
Carotid Endarterectomy and Stenting Timing
To compare the safety and efficacy of carotid revascularization performed within 48 hours versus after 14 days in patients with symptomatic carotid stenosis accompanied with MRI-confirmed acute infarction (high signal on…
- Trial name
- CEST (NCT06898151)
- Testing
- CEA/CAS plus best medical treatment
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Xuanwu Hospital, Beijing
Neuropathic Pain
Effect of Multitarget tDCS for Neuropathic Pain
This study aims to conduct a randomized controlled trial to evaluate the effect of multitarget transcranial direct current stimulation (tDCS) on pain, depression, anxiety, quality of life and sleep, in patients with neuropathic…
- Trial name
- NCT06510725
- Testing
- Multitarget tDCS, Single-target tDCS
- Where
- 3 sites in China
- Volunteers
- 204 people
- Sponsor
- Xuanwu Hospital, Beijing
Symptomatic Intracranial Atherosclerotic Stenosis
Medeliver Intracranial Drug Coated Balloon Catheter for Symptomatic Intracranial Atherosclerotic Stenosis
To evaluate the safety and efficacy of the Medeliver® Intracranial Drug-Coated Balloon Catheter (developed by Beijing Jiu Shi Shen Kang Medical Technology Co., Ltd.) in the endovascular treatment of symptomatic intracranial…
- Trial name
- NCT07542938
- Testing
- Intracranial Drug-Coated Balloon Catheter (Medeliver®), Intracranial Balloon Dilatation Catheter (Diveroad®)
- Where
- 15 sites in China
- Volunteers
- 264 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Vertebral Artery Stenosis
Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis
Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery.
- Trial name
- VISTA (NCT05885932)
- Testing
- Drug-eluting stenting plus aspirin and clopidogrel or ticagrelor, Aspirin and clopidogrel or ticagrelor, mono anti-platelet therapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Xuanwu Hospital, Beijing
Central Nervous System Infections
Safety and Efficacy of Ventricular Irrigation for Ventriculitis
Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis.
- Trial name
- NCT06358209
- Testing
- Ventricular irrigation
- Where
- 35 sites in China
- Volunteers
- 310 people
- Sponsor
- RenJi Hospital
Spinal Cord Injury, Acute Spinal Cord Injury (SCI)
Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn whether expansile duraplasty can improve neurological recovery in adult patients with acute severe traumatic spinal cord injury, as well as evaluate the safety of this surgical…
- Trial name
- GLAD (NCT07733401)
- Testing
- Expansile duraplasty
- Where
- 13 sites in China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Relevant Conditions Identification
Improving the Reliability of LLMs as Medical Assistants for the General Public
This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public.
- Trial name
- LAMP-1 (NCT07651280)
- Testing
- three minutes six dimensions education, ChatGPT, Gemini
- Where
- China
- Volunteers
- 527 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Creutzfeldt-Jakob Disease
Efavirenz for the Treatment of Creutzfeldt-Jakob Disease
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial designed to evaluate the efficacy and safety of efavirenz in patients with Creutzfeldt-Jakob disease (CJD).
- Trial name
- NCT07482085
- Testing
- Efavirenz
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke
AI-Driven Health Management to Prevent Ischemic Stroke in High-Risk Adults
This study will evaluate whether an artificial intelligence (AI)-driven dynamic health management strategy can help prevent ischemic stroke in adults at high risk of stroke.
- Trial name
- AI-ExpoStroke (NCT07779668)
- Testing
- Usual Community-Based Health Management, AI-Driven Dynamic Health Management
- Volunteers
- 26,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder
Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression
The goal of this clinical trial is to evaluate whether precision closed-loop neuromodulation treatments can improve depressive symptoms and daily functioning in people with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT07783906
- Testing
- Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Cognitive Impairment
Scaffolding in AI-Empowered Cognitive Training Improves Outcomes in Cognitive Impairment
This retrospective study aimed to validate and compare two individualized, closed-loop, AI-driven computerized cognitive training programs with a conventional non-AI training program in a real-world clinical setting.
- Trial name
- NCT07788209
- Testing
- AI-Based Adaptive CCT Optimized for Cognitive Improvement, AI-Based Adaptive CCT Optimized for Cognitive Performance, Conventional Non-AI CCT
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Xuanwu Hospital, Beijing