Clinical trials: sponsored by Turku University Hospital
Asthma
Viral Inception of Asthma: Prospective Study From Infancy to School-age
The purpose of this study is to study prospectively the early clinical and immunological events in children susceptible to rhinovirus induced early wheezing (i.e., recently found highest risk factor for recurrent wheezing/asthma)…
- Trial name
- VINKU2 (NCT00731575)
- Testing
- prednisolone
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Turku
Healthy
Effect of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol
Tramadol is an opioid analgesic, which is widely used in the treatment of acute and neuropathic pain. After oral administration, tramadol is rapidly and almost completely absorbed.
- Trial name
- NCT01304069
- Testing
- Selecoxib, Etoricoxib
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Shoulder Arthroscopy
Continuous Subacromial Bupivacaine
The investigators wanted to re-evaluate the effects of subacromial bupivacaine infusion after shoulder arthroscopy with standard surgical techniques, including rotator cuff operations.
- Trial name
- NCT01377415
- Testing
- bupivacaine
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Bone Tumors
Bioactive Glass Granules in Filling of Bone Defects
This is a randomized clinical trial that will be carried out to examine the use of bioactive glass granules (S53P4) as bone graft substitute in filling small and large bone defects as compared with autogenous and allogeneic bone…
- Trial name
- NCT01304121
- Testing
- Bioactive glass (SP53P4)
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Turku University Hospital
Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine
Effects of Posaconazole and Voriconazole on the Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine
Variability in drug response can be due to either pharmacokinetic or pharmacodynamic factors. The reasons why people differ in pharmacokinetics or pharmacodynamics are manifold and include, e.g., genetic factors, diseases, age…
- Trial name
- PosaBupre (NCT01367808)
- Testing
- vorikonazole, posakonazole
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type 2 Diabetes Mellitus, Healthy Volunteers
The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes
The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive…
- Trial name
- HITPET (NCT01344928)
- Testing
- HIT exercise intervention, Aerobic exercise intervention
- Where
- Finland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Turku University Hospital
Arteriosclerosis Obliterans
Preoperative Heart Rate Variability and Baroreflex Sensitivity in ASO Patients During Various Sleep Stages
The goal of this study is to evaluate the possible preoperative predictive value of altered heart rate variability (HRV) and baroreflex sensitivity in different sleep stages for postoperative adverse cardiac events (i.e.
- Trial name
- Barosleep (NCT00712946)
- Where
- Finland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Pharmacokinetics, Pharmacodynamics
Effect of Itraconazole and Ticlopidine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol
Tramadol is an opioid analgesic, which is widely used in the treatment of acute and neuropathic pain. After oral administration, tramadol is rapidly and almost completely absorbed.
- Trial name
- NCT01214941
- Testing
- Ticlopidine, Ticlopidine and itraconazole
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
GERD
Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication
This is a long-term follow-up of a prospective randomized trial comparing open and laparoscopic Nissen fundoplication.
- Trial name
- NCT01230944
- Testing
- Laparoscopic Nissen fundoplication, Open Nissen fundoplication
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Bone Substitutes
Bioactive Glass Composite Implants in Cranial Bone Reconstruction
The purpose of this study is to study composites of bioactive glass and methylmetacrylate with glass fibre reinforcement in cranial bone defect reconstruction.
- Trial name
- NCT01202838
- Testing
- Composite Implant
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Neuromuscular Blocking Agents
Effect of Nitrous Oxide on Cisatracurium Infusion Demands
Background: Recent studies have questioned our previous understanding on the effect of nitrous oxide on muscle relaxants, since nitrous oxide has been shown to potentiate the action of bolus doses of mivacurium, rocuronium and…
- Trial name
- NCT01152905
- Where
- Finland
- Volunteers
- 70 people
- Sponsor
- Turku University Hospital
Gut Microbiota, Skin Microbiota
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in…
- Conditions
- Gut Microbiota, Skin Microbiota, Humoral Immune Responses, Severity of Atopic Dermatitis
- Trial name
- NCT01148667
- Testing
- Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
CYP3A Phenotyping, CYP3A5 and MDR1 Genotyping
Study of Usefulness of Genotyping to Predict Docetaxel Exposure and Adverse Events
Twenty patients with verified high risk breast cancer will be included in the study. Patients will receive three cycles of docetaxel followed by three cycles of CEF for their adjuvant treatment.
- Conditions
- CYP3A Phenotyping, CYP3A5 and MDR1 Genotyping, Docetaxel Toxicity, Associations Between Genetic Data and Docetaxel Toxicity
- Trial name
- Docetaxel (NCT01110291)
- Testing
- docetaxel + CEF
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Turku
Hip Osteoarthritis
Comparison of Hip Resurfacing and Cementless Metal-on-metal Total Hip Arthroplasty
To compare clinical, functional and radiological outcome after hip resurfacing and cementless metal-on-metal total hip arthroplasty.
- Trial name
- NCT00570167
- Testing
- Hip resurfacacing, Cementless total hip arthroplasty with m-o-m bearings
- Where
- 3 sites in Finland
- Volunteers
- 71 people
- Sponsor
- University of Helsinki
Infertility, In Vitro Fertilization
Nordic Luveris Study
To study whether addition of human LH hormone (Luveris) during the final days of stimulation with recombinant FSH (Gonal-f) for controlled ovarian stimulation will be of benefit for patients undergoing in vitro fertilisation.
- Trial name
- NCT00553293
- Testing
- recombinant luteinizing hormone (Luveris), recombinant follicle stimulating hormone (Gonal-f)
- Where
- Denmark
- Volunteers
- 526 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 1 Diabetes
Intranasal Insulin for Prevention of Type 1 Diabetes
Children born in Turku, Oulu and Tampere university cities in Finland are screened at birth for HLA alleles that carry increased risk to or protection from development of type 1 diabetes.
- Trial name
- NCT00223613
- Testing
- daily intranasal administration of insulin
- Where
- Finland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Turku