Clinical trials: sponsored by Turku University Hospital
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Tick Borne Encephalitis (TBE), Lyme Borreliosis
FINtick - a Prospective Multicenter Study on Tick-borne Infections in Finland
Ticks in Finland can carry several microbes that may infect humans. The best known tick-borne diseases are Lyme borreliosis and tick-borne encephalitis (TBE).
- Conditions
- Tick Borne Encephalitis (TBE), Lyme Borreliosis, Neoehrlichiosis, Tick-Borne Diseases
- Trial name
- FINtick (NCT07897825)
- Where
- 3 sites in Finland
- Volunteers
- 850 people
- Sponsor
- Turku University Hospital
Gestational Diabetes
Liraglutide in the Prevention of Type 2 Diabetes After Gestational Diabetes
Obese women with history of gestational diabetes are in great danger to develop type 2 diabetes (T2D) within 5-10 years after delivery.
- Trial name
- Liragest (NCT04324229)
- Testing
- Liraglutide 6 MG/ML [Victoza]
- Where
- Finland
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pain, Postoperative
Dose Response Study of Dexmedetomidine in Orthopaedic Spine Surgery Patients
To study the multimodal protocol combining adjunct dexmedetomidine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoserespDex (NCT02454881)
- Testing
- Dexmedetomidine, Oxycodone
- Where
- Finland
- Volunteers
- 107 people
- Sponsor
- Turku University Hospital
Celiac Disease, Celiac Disease in Children
Celiac Disease in Childhood-Adulthood Transition
Aims of this study are to evaluate adolescents with celiac disease during their transition from pediatrics to adult care, and to develop better healthcare follow-up practices.
- Conditions
- Celiac Disease, Celiac Disease in Children, Transition of Care, Follow-up
- Trial name
- CeliCAT (NCT05084937)
- Testing
- CeliCAT form
- Where
- 5 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Tampere University Hospital
Acute Otitis Media, AOM - Acute Otitis Media
Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children
The goal of this trial is to compare amoxicillin to amoxicillin-clavulanate and to placebo in the treatment of acute middle ear infections in small children.
- Trial name
- SAVOtitis (NCT07878910)
- Testing
- Amoxicillin, Amoxicillin + Clavulanate
- Where
- 3 sites in Finland
- Volunteers
- 219 people
- Sponsor
- Kuopio University Hospital
Atheroscleroses, Inflammation
Vascular Inflammation in Atherosclerosis - Whole Body Molecular PET/CT Imaging Using Folate Receptor β
This study investigates inflammation in the blood vessels of people with coronary artery disease (CAD) or a recent myocardial infarction.
- Trial name
- ATHERO-FOL (NCT07877324)
- Testing
- 18F-AlF-NOTA-Folate PET
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Localized Prostate Carcinoma, Castration-Naive Prostate Cancer
Neoadjuvant ADT With TULSA in the Treatment of Intermediate Risk Prostate Cancer
Clinical studies have shown that magnetic resonance imaging-guided transurethral ultrasound ablation (TULSA) of the prostate is safe and effective. In the TULSA procedure, prostate tissue is killed by heating with ultrasound.
- Conditions
- Localized Prostate Carcinoma, Castration-Naive Prostate Cancer, Intermediate Risk Prostate Cancer, Prostate Cancer
- Trial name
- NeoADT-TULSA (NCT05917860)
- Testing
- Degarelix, MRI-guided transurethral ultrasound ablation (TULSA)
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Turku University Hospital
Pulmonary Sarcoidosis
Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis
The goal of the current study is to evaluate the potential of the selected PET tracers to detect sarcoidotic lesions in lungs. The tracers are already in clinical use for the detection of certain inflammatory processes or…
- Trial name
- NCT02824419
- Testing
- Methionine, DOTANOC
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Turku University Hospital
Possible Interaction Between Losartan and Cephalexin, Healthy
The Effect of Losartan on Cephalexin
The goal of this clinical trial is to investigate the effects of the blood pressure-lowering drug losartan on the blood levels and urinary excretion of the antibiotic cephalexin during simultaneous and staggered ingestion in…
- Trial name
- KEFALOS (NCT07300670)
- Testing
- losartan, cephalexin
- Where
- Finland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Aleksi Tornio
Rectal Cancer, Rectal Adenocarcinoma
Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
The goal of this one-arm clinical trial is to implement and study the oncological outcomes of nonoperative management of rectal cancer having complete clinical response to neoadjuvant therapy.
- Trial name
- NORPPA-1 (NCT06328361)
- Testing
- Nonoperative surveillance
- Where
- 13 sites in Estonia, Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Arthrosis
Changes in Physical Activity, Sleep and Knee Function After Same-Day Discharge Knee Arthroplasty
The goal of this observational study is to examine changes in physical activity, sleep quality, knee extension and flexion strength, knee range of motion, and patient-reported outcomes before and after same-day discharge knee…
- Trial name
- ORTOMOVE (NCT07840391)
- Testing
- Medial unicompartmental knee arthroplasty (UKA), Total knee arthroplasty (TKA)
- Where
- 2 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Infection Post Op, Hysterectomy
Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections
During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%.
- Conditions
- Infection Post Op, Hysterectomy, Antibiotics, Prophylactic
- Trial name
- NCT05337566
- Testing
- Azithromycin Pill + Cefuroxime
- Where
- 6 sites in Finland
- Volunteers
- 2,278 people
- Sponsor
- Helsinki University Central Hospital
Healthy, Vaginal Discharge
Vaginal and Oral Microbiome Crosstalk
To study the vaginal and oral microbiome by swab samples. On selected cases, also papa smear will be studied.
- Trial name
- NCT02898818
- Testing
- vaginal and oral swab sample, questionnaire, papa smear
- Where
- Finland
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Otitis Media, Otitis Media
Parent-led Assessment and Recognition of AOM Using Digital Ear Imaging
Acute otitis media (AOM) is the most common bacterial infection in young children and a major contributor to healthcare utilization and costs.
- Trial name
- PARENT-EAR (NCT07640568)
- Testing
- Assigning of a digital otoscope to the families in the intervention group
- Where
- 2 sites in Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Necrotizing Soft Tissue Infection
Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial).
Necrotizing soft-tissue infection (NSTI) is a rare, severe, fast-progressing bacterial infection within the soft tissue compartment. The NSTI mortality rate remain high and largely unaltered in the last decades.
- Trial name
- HOT-NSTI (NCT07489274)
- Testing
- Hyperbaric oxygen treatment, Standard of Care (Investigator Choice)
- Where
- 2 sites in Belgium, Norway
- Volunteers
- 1,480 people
- Sponsor
- Ole Hyldegaard
Uterine Fibroids (Leiomyoma)
Microwave Ablation of Uterine Fibroids
This prospective observational study aims to evaluate the effectiveness and acceptability of percutaneous or vaginal ultrasound guided microwave ablation for the treatment or symptomatic uterine fibroids.
- Trial name
- MyoMwa (NCT07780019)
- Testing
- microwave ablation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Borderline Symptoms, Borderline Personality Disorder
The Effectiveness of Group Schema Therapy in the Treatment of Borderline Symptoms in Adolescents
The goal of this randomized and controlled trial is to assess the effectiveness of group schema therapy in the treatment of adolescents with borderline symptoms.
- Trial name
- NCT06606002
- Testing
- Group schema therapy, Treatment as Usual (TAU)
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Turku University Hospital
Infratentorial Neoplasms, Mutism
Cerebellar Mutism Syndrome Study
The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS).
- Trial name
- NCT02300766
- Where
- 32 sites in Austria, Belgium and 12 more
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet