Clinical trials: not yet recruiting
Hip Fracture Surgeries, High Risk Population of Hip Fractures
A Decision Support Tool for Common Surgical Fixations of Hip Fractures
This study aims to improve how patients, families, and healthcare professionals work together to make important medical decisions, especially in cases involving hip fractures.
- Conditions
- Hip Fracture Surgeries, High Risk Population of Hip Fractures, Decision Surrogate of Hip Fixations
- Trial name
- NCT07909876
- Testing
- IDeA for Hip Fracture, Non-IDeA for hip fracture
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Crowding of Teeth, Malocclusion; Displaced Teeth
Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE)
Dental crowding is the most common malocclusion affecting up to 45% of the population and represents one of the leading reasons for seeking orthodontic treatment.
- Conditions
- Crowding of Teeth, Malocclusion; Displaced Teeth, Malocclusion in Children
- Trial name
- cSPACE (NCT07911176)
- Testing
- Early first premolar extraction with observation, Early first premolar extraction with planned fixed orthodontic treatment
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee
PPV-06 Vaccine in Inflammatory Knee Osteoarthritis
PPV-06 targets interleukin-6, a key molecule implicated in many inflammatory diseases such osteoarthritis. PPV-06 is used to induce the production of antibodies directed against IL-6.
- Trial name
- NCT06605963
- Testing
- PPV-06
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Peptinov SAS
Breast Cancer, Advanced Breast Cancer
Trastuzumab Deruxtecan and Lovastatin in HER2-low and Ultralow Advanced or Metastatic Breast Cancer
The purpose of this study is to evaluate the use of lovastatin, a cholesterol-depleting pro-drug that may lower CAV-1 levels, in order to increase HER2 expression on the cell surface of cancer cells and enhance the uptake and…
- Conditions
- Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT07619365
- Testing
- Trastuzumab deruxtecan, Lovastatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
X-linked Adrenoleukodystrophy
IT and IV Lentiviral Gene Therapy for X-ALD
This is a Phase I/II clinical trial of gene therapy for treating X-linked adrenoleukodystrophy using a high-safety, high-efficiency, self-inactivating lentiviral vector (LV) TYF-ABCD1 to functionally correct the defective gene.
- Trial name
- NCT03727555
- Testing
- Intrathecal and intravenous LV gene therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Hemorrhoidal Disease
A Three-Arm, Randomized, Placebo-Controlled, Double-Blind Phase 2 Study to Evaluate the Safety and Efficacy of Two Dosage Regimens of a Novel Hydrocortisone Acetate Suppository Formulation Administered With a Proprietary Suppository Applicator in Subjects With Hemorrhoidal Disease
The goal of this clinical trial is to evaluate the efficacy of two dosage regimens of hydrocortisone acetate suppository administered with a proprietary suppository applicator (Study Drug) compared to placebo in the treatment of…
- Trial name
- NCT07909291
- Testing
- hydrocortisone acetate 50 mg, hydrocortisone acetate 75 mg, proprietary suppository applicator
- Volunteers
- 78 people
- Sponsor
- Cristcot LLC
End Stage Kidney Disease (ESKD), Hypertension (HTN)
Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot Trial
The GOAL-BP pilot study will help determine whether a study comparing two blood pressure goals can be carried out in adults with end-stage kidney disease and high blood pressure who receive peritoneal dialysis.
- Conditions
- End Stage Kidney Disease (ESKD), Hypertension (HTN), Peritoneal Dialysis (PD)
- Trial name
- GOAL-BP (NCT07910773)
- Testing
- Target systolic blood pressure <120 mmHg., Target systolic blood pressure <140 mmHg
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Non-invasive Donor Liver Assessment
Comparison of Liver Biopsy Versus Fibroscan With CAP ( Controlled Attenuation Parameter) in Donors Evaluation for Liver Transplant
In our study we aiming that liver biopsy histological analysis as a reference standard, to examine the precision of fbroscan controlled attenuation parameter (CAP) for quantitative evaluation of macrovesicular steatosis in living…
- Trial name
- DonorFibroScan (NCT07451379)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ischemic Stroke
Brain-Machine Interface With Virtual Reality and Neuromuscular Electrical Stimulation for Upper Limb Rehabilitation After Stroke
Stroke is a major cause of long-term disability, and many stroke survivors experience persistent difficulties moving and using their affected arm and hand.
- Trial name
- NCT07911384
- Testing
- Brain-Machine Interface Training With Virtual Reality and NMES, Neuromuscular Electrical Stimulation
- Where
- Portugal
- Volunteers
- 68 people
- Sponsor
- Marta Sofia Ramos Torres
Glioma Patients
Flubendazole Added to Standard Concurrent Chemoradiotherapy With Temozolomide in Patients With High-Grade Glioma
This study To evalute the efficacy and safety of adding flubendazole to standard concurrent chemoradiotherapy with temozolomide in patients with high grade glioma and also to evaluate DFS,OS for those patients in clinical…
- Trial name
- NCT07847476
- Testing
- Flubendazole
- Volunteers
- 122 people
- Sponsor
- Assiut University
Cognitive Impairment, Chronic Traumatic Encephalopathy (CTE)
A Prospective Study of Cognitive Changes in Retired and Late-Career Professional Soccer Players
Repeated head impacts and concussions may be associated with cognitive difficulties and neurodegenerative changes in athletes. Although this association has been studied primarily in contact sports such as boxing and American…
- Trial name
- TC COG (NCT07910994)
- Volunteers
- 75 people
- Sponsor
- University Hospital, Strasbourg, France
Premenstrual Syndrome
Integrated Core Stability Exercises and Yoga Program on Premenstrual Syndrome
This study aims to evaluate the effect of an integrated yoga and core stability exercises program on the severity of premenstrual syndrome symptoms and quality of life among nursing students.
- Trial name
- Exercise (NCT07889141)
- Testing
- exercises program
- Where
- 2 sites in Egypt
- Volunteers
- 92 people
- Sponsor
- Mansoura University
Portal Hypertension Related to Cirrhosis, Ascites
Development and Validation of a TIPS Prognostic Model
This multicenter, prospective observational study aims to learn whether a prediction model using routine clinical data, imaging findings (including spleen stiffness measurement), and circulating biomarkers can predict stent…
- Conditions
- Portal Hypertension Related to Cirrhosis, Ascites, Esophageal Variceal Bleeding
- Trial name
- C-SIPS (NCT07909850)
- Volunteers
- 1,490 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Acute Myeloid Leukemia
Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of multi-CAR T cell therapy targeting different AML surface antigens in patients with relapsed or refractory acute myeloid leukemia (AML).
- Trial name
- NCT03222674
- Testing
- Muc1/CLL1/CD33/CD38/CD56/CD123-specific gene-engineered T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Myeloma
A Randomized Controlled Trial of a Wearable Core Body Temperature Sensor Versus Standard Temperature Monitoring for Early Detection of Cytokine Release Syndrome in Patients Undergoing CAR T-Cell Therapy in an Outpatient Setting
The purpose of this research study is to see if a wearable temperature monitoring patch can detect cytokine release syndrome earlier than traditional oral temperature monitoring.
- Trial name
- NCT07911540
- Testing
- TempShield Continuous Temperature Monitoring, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia
A Study to Assess the Safety, Tolerability and Pharmacokinetics of XEP527 in Patients With Stable Schizophrenia
This study is designed to assess the safety and tolerability of the effects of XEP527, with particular emphasis on disease status and its compatibility with the standard of care in patients with stable schizophrenia.
- Trial name
- NCT07908680
- Testing
- XEP527
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Breastfeeding Expectations, Breastfeeding Avoidance
The Effect of a Virtual Reality Breastfeeding Experience on Breastfeeding Expectations and Avoidance
This randomized controlled trial aims to examine the effect of a virtual reality breastfeeding experience on breastfeeding expectations during pregnancy and breastfeeding avoidance after childbirth.
- Trial name
- NCT07901010
- Testing
- Simulation of Virtual Reality
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ebru Ertas
Oral Lichen Planus
Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus
Background: Oral Lichen Planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, with the erosive form causing painful ulcerations and erosions, significantly impacting the patient's quality of life and…
- Trial name
- NCT07910175
- Testing
- Nano- Curcumin-Mediated Photodynamic Therapy (PDT), Photobiomodulation Therapy (PBM)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Alexandria University
Discogenic Low Back Pain
PRP Versus NP Injections for Chronic Discogenic Low Back Pain
The purpose of this randomized, single-blind comparative-effectiveness pilot study is to compare the effectiveness of two types of injections on pain and function over 6 months in patients with chronic discogenic (originating…
- Trial name
- NCT07895225
- Testing
- Platelet-Rich Plasma (PRP) Injection, Nucleus Pulposus (NP) Injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Walter Reed National Military Medical Center
Femoropopliteal In-Stent Restenosis (ISR)
Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis
Femoropopliteal in-stent restenosis (ISR) remains an important cause of recurrent symptoms and repeat revascularization after lower-extremity endovascular treatment.
- Trial name
- NCT07277218
- Testing
- Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy
- Where
- 10 sites in China
- Volunteers
- 600 people
- Sponsor
- Chunshui He
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.