Clinical trials: sponsored by Duke University
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Cancer, Youth Cancer
Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors
The purpose of this study is to evaluate the feasibility and acceptability of the Mindset Moments™ (MM™) program in managing psychological distress and resiliency in adolescent and young adult cancer survivors.
- Conditions
- Cancer, Youth Cancer, Young Adult Cancer, Distress, Psychological
- Trial name
- NCT06732375
- Testing
- Mindset Moments
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Infections
CIED Infection Quality Initiative Demonstration Project
The aim of this Quality Initiative (QI) demonstration project is to develop a model to increase guideline-driven care for patients with cardiovascular implantable electronic devices (CIED) infection.
- Trial name
- RECTIFY (NCT05471973)
- Testing
- Multidisciplinary Team, Outreach Visits, Multifaceted Intervention
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Chronic Pain, Depression, Anxiety
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain.
- Trial name
- NCT06978166
- Testing
- Just-In-Time Adaptive Interventions (JITAIs), Wysa for Chronic Pain
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Glycogen Storage Disease Type IV, Adult Polyglucosan Body Disease
GBE Deficiency (GSD IV and APBD) Natural History Study
Collection and review of clinical information related to glycogen branching enzyme (GBE) deficiency, diagnosed as Glycogen Storage Disease Type IV (GSD IV) or Adult Polyglucosan Body Disease (APBD generated during clinic visits.
- Conditions
- Glycogen Storage Disease Type IV, Adult Polyglucosan Body Disease, GSD4, GSD IV
- Trial name
- NCT02683512
- Testing
- No intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Post Intensive Care Syndrome (PICS)
Surviving the Pediatric Intensive Care Unit (PICU)
Improvement in pediatric intensive care unit (PICU) supportive care has led to improvement in clinical outcomes and decreased mortality in pediatric critical illness.
- Trial name
- NCT06812130
- Testing
- This is a non-interventional study.
- Where
- 2 sites in Singapore
- Volunteers
- 404 people
- Sponsor
- KK Women's and Children's Hospital
Lung Cancer Metastatic
A Randomized Pilot Study of Evolocumab Plus Nivolumab/Ipilimumab in Treatment-Naïve Patients With Metastatic NSCLC
This is a research study to find out the safety and tolerability of combining the drug evolucumab with standard immunotherapy in people with advanced lung cancer (a type called non-small cell lung cancer).
- Trial name
- TOP2101 (NCT05144529)
- Testing
- Nivolumab, Ipilimumab, Evolocumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Eziafa Oduah, MD, PhD, MPH
Sickle Cell Disease, Chronic Pain
Predictors of Pain in Sickle Cell Disease
Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling.
- Trial name
- NCT06139510
- Testing
- Quantitative sensory testing
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Duke University
ADHD - Attention Deficit Disorder With Hyperactivity, ADHD
Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition
The purpose of this study is to better understand sleep and circadian functioning in children with ADHD using home-based measures, parent report, and a lab based melatonin assessment.
- Trial name
- CIRCA (NCT06971640)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Duke University
Glaucoma, Glaucoma, Suspect
Reliability and Reproducibility of the Eye Check Tonometer
To investigate whether the new applanation tonometer (EyeCheck monitor) can provide intraocular pressure (IOP) measurements comparable to those of traditional tonometers such as the Goldmann applanation tonometer and the Tonopen.
- Trial name
- EyeCheck (NCT04639947)
- Testing
- EyeCheck, Traditional Tonometer (Goldmann and Tonopen)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Surgery
Collecting Outcomes and Managing Pain After Surgery
The primary aim of this study is to measure pain and psychosocial patient reported outcomes, objective functionality, and actual daily at home opioid usage in orthopedic patients.
- Trial name
- COMPAS (NCT03834818)
- Testing
- COMPAS Participants
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Heart Failure
Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction
Heart failure (HF) affects more than 6 million adults in the U.S. alone, with increasing prevalence. Cardiovascular congestion with resultant limitation in physical activity is the hallmark of chronic and decompensated HF.
- Trial name
- Splanchnic X (NCT06733012)
- Testing
- Splanchnic nerve block
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Duke University
Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1
GSD VI and GSD IX Natural History
Collection and review of clinical information related to Glycogen Storage Disease Type VI (GSD VI) OR Glycogen Storage Disease Type IX (GSD IX) generated during clinic visits.
- Conditions
- Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1, GLYCOGEN STORAGE DISEASE IXa2, Glycogen Storage Disease IXB
- Trial name
- NCT04454216
- Testing
- No intervention
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Heart Transplant Failure and Rejection, Heart Failure
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a…
- Conditions
- Heart Transplant Failure and Rejection, Heart Failure, Heart Diseases, Heart Failure，Congestive
- Trial name
- HEARTBiT (NCT03575910)
- Where
- 4 sites in United States, Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Smoking, Homeless Persons
Contingency Management for Smoking Cessation in Homeless Smokers
The purpose of this study is to examine the effectiveness of an internet-based contingency management program for smoking cessation in persons who are homeless. Thirty homeless smokers will be enrolled in the study.
- Trial name
- NCT01789710
- Testing
- Bupropion, Nicotine replacement therapy, Contingency Management
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Bladder Cancer
Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy
The project will include 30 patients with bladder cancer who are candidates for bladder removal. After signing the consent form, the study team will collect some clinical data, such as age, past medical history, past surgical…
- Trial name
- SR-ULM BC (NCT06986304)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Healthy
Hyperpolarized 129Xe MRI Lung Health Cohort
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function.
- Trial name
- XeLHC (NCT05766384)
- Testing
- Hyperpolarized Xe129
- Where
- 6 sites in United States
- Volunteers
- 260 people
- Sponsor
- University of Kansas Medical Center
Acute Ischemic Stroke
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders…
- Trial name
- TESSERACT 2 (NCT06440707)
- Testing
- High-definition Cathodal Transcranial Direct Current Stimulation (HD C-tDCS)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
ADCT-301 in Patients With R/R AML, MDS, or MDS/MPN
This is research study to find out if a drug called ADCT-301 is safe and to look at how patients respond to the study drug after an allogeneic transplantation.
- Conditions
- Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Myeloproliferative Neoplasm (MDS/MPN)
- Trial name
- NCT04639024
- Testing
- ADCT-301
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Gwynn Long, M.D.
Critical Illness
Multi-component Family Support Tool Intervention (FST)
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually or survive…
- Trial name
- FST (NCT05019261)
- Testing
- Multi-component Family Support Intervention
- Where
- 7 sites in United States
- Volunteers
- 1,039 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
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