Clinical trials: sponsored by Unity Health Toronto
Early Detection of Cancer, Cancer
Comparing Methods of Recall for Cancer Screening in Primary Care: a Pragmatic Clinical Trial
This randomized trial aims to understand how effective a reminder letter is compared to a reminder phone call in improving breast, cervical and colorectal cancer screening rates and reducing screening disparities.
- Conditions
- Early Detection of Cancer, Cancer, Socioeconomic Status
- Trial name
- NCT02457143
- Testing
- Letter, Phone call
- Where
- Canada
- Volunteers
- 5,270 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Overweight
Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Canadian statistics indicate that the incidence of obesity is increasing and that the occurrence of diabetes in obese individuals is 5-fold greater than those with a healthy weight, making weight control in this population…
- Conditions
- Diabetes Mellitus, Overweight, Obesity
- Trial name
- LOSS (NCT01403571)
- Testing
- Salba (Salvia hispanica L.), Oat-based Control
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type II Diabetes Control
Effect of Ginseng in Type 2 Diabetes
Objective: We aim to evaluate longer term efficacy and safety of AG as an add-on therapy in patients with type 2 diabetes controlled by conventional treatment.
- Trial name
- NCT02923453
- Testing
- CNT 2000 American ginseng extract
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Unity Health Toronto
Aortic Stenosis, Cardiac Valve Replacement Complication
Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions
Frailty is a state of decreased physiologic reserves and vulnerability to stressors. Several tools exist to measure frailty, some based on physical tests and others on questionnaires, yet there is no agreement on which tool to…
- Conditions
- Aortic Stenosis, Cardiac Valve Replacement Complication, Fragility
- Trial name
- NCT01845207
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 800 people
- Sponsor
- Jewish General Hospital
Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors
EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELs
Sub epithelial lesions (SELs) of the gastrointestinal (GI) tract are commonly identified during routine endoscopy. Most of these lesions are benign.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms
- Trial name
- NCT02866045
- Testing
- EUS-guided fine needle biopsy, Single incision needle knife biopsy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Self-regulation, Forethought
Exploring Self-regulatory Processes in Anesthesiologists During Massive Transfusion
The purpose of the project is to investigate the function of self-regulatory processes in anesthesiologists and how application of these processes influence performance in a crisis situation.The investigators intend to explore…
- Conditions
- Self-regulation, Forethought, Performance
- Trial name
- NCT02199210
- Testing
- Prompting forethought
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
End Stage Renal Disease
The Use of Furosemide in Patients on Dialysis
Patients often begin dialysis taking diuretics (stimulate the kidney to excrete salt and water). Once on dialysis, these drugs are often continued.
- Trial name
- NCT01815892
- Testing
- Withdrawal of furosemide, furosemide administration
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Revascularization Strategies for STEMI; The CMR Endpoint Study
Revascularization strategies for ST elevation myocardial infarction (STEMI) study (ASSIST-CMR) will compare the effects of two revascularization strategies [same sitting multivessel primary PCI (SS-PCI) and culprit vessel only…
- Trial name
- ASSIST-CMR (NCT01818960)
- Testing
- IRA-PCI, SS-PCI
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Unity Health Toronto
Myocardial Infarction
Chronic Remote Ischemic Conditioning to Modify Post-MI Remodeling
During a heart attack, an artery carrying blood and oxygen to the heart becomes blocked, which causes damage to the heart muscle.
- Trial name
- CRIC-RCT (NCT01817114)
- Testing
- Auto Remote Ischemic Conditioning (AutoRIC) device
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Blood Pressure
Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials
High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality.
- Trial name
- CHO-MUFA (NCT02626325)
- Testing
- High-carbohydrate or High-monounsaturated fat diets
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Type 2
Konjac-Glucomannan Fibre Blend and American Ginseng in Type 2 Diabetes
The purpose of this study was to determine whether the co-administration of a konjac-glucomannan fibre blend and American ginseng in a randomized, placebo-controlled, cross-over trial can improve diabetes management.
- Trial name
- NCT02806349
- Testing
- American Ginseng, Konjac-glucomannan fiber blend, Control
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Vladimir Vuksan
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
CARDIOVASCULAR DISEASES
A Multi-centered Feedback and Education Intervention Designed to Reduce Inappropriate Transthoracic Echocardiograms
This study is an international, prospective, multi-centred, investigator blinded, randomized control trial of an educational and feedback-based intervention vs.
- Trial name
- NCT02038101
- Testing
- Education and Feedback
- Where
- 6 sites in United States, Canada
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Agitation
Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Our proposal is to administer asenapine to patients who are clinically agitated and in need of immediate intervention. At present there are no controlled studies that we know of that explores the use of asenapine for this…
- Trial name
- NCT01400113
- Testing
- Asenapine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
End Stage Renal Disease, Kidney Failure
Virtual Ward for Home Dialysis
Home based renal replacement therapy (RRT), including peritoneal dialysis (PD) and home hemodialysis(HHD), offers enhanced quality of life and clinical advantages compared to conventional in-center hemodialysis.
- Conditions
- End Stage Renal Disease, Kidney Failure, Home Dialysis
- Trial name
- Virtual Ward (NCT01912001)
- Testing
- Telephone follow-up, Sympton Assessment
- Where
- 7 sites in Canada
- Volunteers
- 215 people
- Sponsor
- Christopher Chan
C.Surgical Procedure; Cardiac
HELIox CardiOPlegia Trial During Cardiac surgERy
The HELICOPTER-1 Trial is a single centre pilot study to determine the feasibility of administering Heliox in cardioplegia during cardiac surgery and whether it has the potential to reduce the incidence and severity of myocardial…
- Trial name
- HELICOPTER-1 (NCT02745951)
- Testing
- Heliox, Standard of care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Acute HIV Infection
Effects of Intensive cART During Acute/Early HIV Infection
This trial will investigate the efficacy and safety of intensified antiretroviral treatment that includes raltegravir and maraviroc during the early stages of HIV infection.
- Trial name
- NCT01154673
- Testing
- raltegravir, maraviroc, emtricitabine 200mg /tenofovir 300mg
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- University of Toronto
Breast Cancer
Monitoring of Breast Tissue Change Due to Hormone Replacement Therapy in Post-menopausal Women Using OBS
Hormone Replacement Therapy (HRT) is a double edged sword: it can alleviate the effects of menopause for a significant proportion of the female population, however for a smaller proportion, it will induce a significant increase…
- Trial name
- TiBS-HRT (NCT00797199)
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy
Comparison of Dietary Fats on Vascular Parameters
The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels.
- Trial name
- COIL (NCT01876394)
- Testing
- Coconut Oil, Canola Oil, Grapeseed Oil
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes Mellitus
ALA on Glycemic Control in T2DM Participants
With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community.
- Trial name
- NCT02701894
- Testing
- Alpha-Linolenic Acid
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto