Clinical trials: not yet recruiting
Acute Lymphobkastic Leukemia, Medication Adherence
The AYA Oncology Self-care Movement
This trial will test the impact of a social media intervention for improving oral chemotherapy adherence among adolescents and young adults (AYAs) with acute lymphoblastic leukemia.
- Trial name
- #AYAOSM (NCT07724652)
- Testing
- Educational Website, #AYAOSM
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Diabetic Peripheral Neuropathy
Adaptive Gamified Sensory Training on Sensory Function and Limb-Specific Functional Performance in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) will be considered a clinically important complication of diabetes mellitus that may impair sensory function and interfere with the performance of daily activities involving the hands and…
- Trial name
- NCT07907289
- Testing
- Adaptive Gamified Sensory Training, Conventional Physical Therapy Group
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Irreversible Pulpitis, Anesthesia, Local
Cost-Effectiveness of Upfront Supplemental Anaesthesia in Symptomatic Irreversible Pulpitis
The goal of this clinical trial is to learn whether giving extra (supplemental) local anaesthetic injections at the start of treatment, rather than only after the standard injection fails, makes numbing of painful lower molar…
- Trial name
- UPFRONT-SIP (NCT07907120)
- Testing
- Inferior Alveolar Nerve Block With 2% Lidocaine With 1:80,000 Adrenaline, Upfront Buccal Infiltration With 4% Articaine With 1:100,000 Adrenaline, Upfront Intraligamentary Injection With 2% Lidocaine With 1:80,000 Adrenaline
- Where
- India
- Volunteers
- 234 people
- Sponsor
- Jamia Millia Islamia
Patello-femoral Osteoarthritis
Hybrid Closed Wedge High Tibial Osteotomy
Osteoarthritis (OA) is the most prevalent condition of the knee joint. High tibial osteotomy (HTO) is an effective treatment for medial compartmental osteoarthritis (OA) of the knee with good clinical outcomes.
- Trial name
- NCT07907159
- Testing
- Hybrid Closed Wedge High Tibial Osteotomy
- Volunteers
- 20 people
- Sponsor
- Assiut University
Cortical Blindness
Multisensory Rehabilitation of Vision Loss After Cortical Damage
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
- Trial name
- NCT07659691
- Testing
- Multisensory Rehabilitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Forward Head Posture, Chronic Nonspecific Neck Pain
Digital Use, 24-Hour Movement Behaviors, and Myofascial Release in University Students With Neck Pain
This study will examine how smartphone use recorded by the phone and daily sleep, sitting, and physical activity are related to neck posture, sensitivity to pressure, and body awareness in university students aged 18 to 30 years.
- Trial name
- NCT07907458
- Testing
- Integrated Myofascial Release, Light-Touch Control
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Karabuk University
Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
This study is for adults aged 18 years and older who have a type of fatty liver disease called metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- NCT07850063
- Testing
- Survodutide
- Where
- 34 sites in United States, China and 3 more
- Volunteers
- 600 people
- Sponsor
- Boehringer Ingelheim
Critical Illness Recovery, Mental Health
Building Resilience Through Anxiety Virtual Education in PICU Survivors
Survivors of Pediatric Intensive Care Unit (PICU) admissions often experience adverse mental health consequences, either as a result of, or associated with, their intensive care stay.
- Trial name
- BRAVE-PICU (NCT07906366)
- Testing
- Digital Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Solid Tumors
A Study to Evaluate the Safety and Effectiveness of Different Doses of RO7836748 Alone or in Combination With Other Cancer Therapies in People With Solid Tumors With a Rat Sarcoma Viral Oncogene Homolog Glycine 12 Valine (RAS G12V) Mutation
The study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of RO7836748 as monotherapy and in combination with other anti-cancer therapies, including…
- Trial name
- NCT07905924
- Testing
- RO7836748, Pembrolizumab, mFOLFIRINOX
- Volunteers
- 540 people
- Sponsor
- Hoffmann-La Roche
Amyotrophic Lateral Sclerosis (ALS)
A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS)
This is a first-in-human study of NI112, an investigational medicine given as an injection under the skin, in adults with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT07906665
- Testing
- NI112
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sachi Bioworks Inc.
Moderate to Severe Insomnia
HALO Clarity™ Cranial Alternating Current Stimulation Therapy for Adults With Moderate-to-Severe Insomnia
A prospective, decentralized, individually-randomized, triple-blind* sham-controlled, superiority trial to evaluate the safety and efficacy of HALO Clarity™ device in reducing insomnia severity.
- Trial name
- NCT07659366
- Testing
- Transcranial alternating current stimulator
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nexalin Technology
Parkinson Disease
Estimates of the Efficacy of Talineuren (TLN) and Placebo in Patients With Parkinson Disease
This study is double-blinded placebo controlled followed by an open-label extension placebo-to-active switch to estimate the efficacy of Talineuren.
- Trial name
- LIBRA (NCT06431971)
- Testing
- Talineuren
- Where
- 6 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- InnoMedica Schweiz AG
Neuropathic Pain, Chronic Pain
Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain
This is a study evaluating the Scrambler Therapy device as a non-invasive treatment for neuropathic pain in pediatric oncology patients with metastatic bone disease.
- Trial name
- PEACE-NP (NCT07264920)
- Testing
- Scrambler Therapy MC-5A Device
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University
Kidney Transplantation, Delayed Graft Function
Bioimpedance and Multiparametric Ultrasound-Guided Fluid Management After Kidney Transplantation
After a kidney transplant, the amount of fluid in the body must be carefully balanced. Too much fluid can accumulate in the lungs, the tissues and the new kidney itself and may delay its recovery; too little fluid can also damage…
- Conditions
- Kidney Transplantation, Delayed Graft Function, Fluid Overload
- Trial name
- VLMM-MC (NCT07905963)
- Testing
- Multiparametric assessment, Structured usual care
- Volunteers
- 650 people
- Sponsor
- Hospital Universitario Ramon y Cajal
PSMA Positive Tumors or Tumor Tissues
PSMA-specific CAR-T Cell Therapy
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of PSMA-specific CAR-T cell therapy in patients with PSMA positive tumor.
- Trial name
- NCT04429451
- Testing
- 4SCAR-PSMA T cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
PTSD, PTSD - Post Traumatic Stress Disorder
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
PRE-EMPT will assemble a cohort of 150 participants from three populations (low risk, intermediate risk, and high risk for self-harm).
- Conditions
- PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression, Suicidality
- Trial name
- PRE-EMPT (NCT07745569)
- Testing
- Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
Varicose Veins
Phenotyping Rehabilitation for Improving Frailty, Functional Capacity
Chronic venous insufficiency (CVI) is associated with reduced mobility, frailty, impaired physical performance, and decreased quality of life in older adults.
- Trial name
- Frailty (NCT07907978)
- Testing
- Phenotype-Guided Individualized Rehabilitation, Standardized Multicomponent Rehabilitation
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Metastatic Non-Small Cell Lung Cancer, Cancer-Associated Weight Loss
Tocilizumab Combined With First-Line Chemo-Immunotherapy in Metastatic Non-Small Cell Lung Cancer
This is a Phase 1b/2, multi-site, single-arm, open-label, non-randomized study looking at whether adding tocilizumab to standard treatment for metastatic Non-Small Cell Lung Cancer (NSCLC) is safe, possible, and effective.
- Conditions
- Metastatic Non-Small Cell Lung Cancer, Cancer-Associated Weight Loss, Elevated Inflammatory Markers
- Trial name
- TOCI (NCT07889232)
- Testing
- Tocilizumab, Pembrolizumab, Platinum-Doublet Chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- VA Office of Research and Development
Myopia
Corneal Biomechanics and Stromal Tissue Characteristics in Patients Undergoing SMILE
This prospective observational cohort study will investigate corneal biomechanical characteristics and their relationships with corneal stromal tissue features in adult patients undergoing clinically indicated small-incision…
- Trial name
- SMILE (NCT07906327)
- Testing
- SMILE
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji University
Hemodialysis, Kidney Disease, End-Stage
Cycling During Dialysis: A Feasibility and Safety Study
People who receive hemodialysis sit for about 4 hours, three times a week, and often feel tired and weak. Exercise can help, but many patients find it hard to exercise on their own.
- Conditions
- Hemodialysis, Kidney Disease, End-Stage, Fatigue
- Trial name
- NCT07905885
- Testing
- Supervised Intradialytic Cycling
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
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