Clinical trials: sponsored by Cedars-Sinai Medical Center
Myocardial Infarction
Safety of Nitroglycerin for Field Treatment of STEMI
The purpose of this study is to quantify the risk of hypotension due to field treatment with nitroglycerin in patients with ST-elevation myocardial infarction, particularly right ventricular infarcts, and secondarily to evaluate…
- Trial name
- NCT02407002
- Where
- 3 sites in United States
- Volunteers
- 940 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Acromegaly
Tissue Biomarker for Pegvisomant Action
Acromegaly is a disease of the pituitary gland that involves overproduction of growth hormone. Pegvisomant works by blocking binding of GH to receptors found in tissues throughout the body.
- Trial name
- NCT01261000
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cedars-Sinai Medical Center
Deglutition Disorders, Stroke
Computerized Acoustic Swallowing Evaluation
It is the purpose of this study to determine if a commercially available electronic stethoscope synchronized with an smart phone or iPad application can be used as an accurate and objective screening tool for measuring dysphagia.
- Trial name
- CASE (NCT02925507)
- Testing
- Swallowing Screen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Inflammatory Bowel Diseases
Individualized Infiximab Dosing-Proof of Concept Study
The purpose of this study is to determine which early infliximab pharmacokinetic level is most associated with clinical remission at weeks 30 and 54 in pediatric IBD patients.
- Trial name
- NCT02027727
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure, Hypogonadism
Testosterone Therapy in Heart Failure
The purpose of this study is to evaluate whether benefits of topical testosterone on symptoms and function of male HF patients, and its effects on rehospitalization rates and quality of life.
- Trial name
- NCT01377103
- Testing
- testerone gel
- Sponsor
- Cedars-Sinai Medical Center
Inflammatory Bowel Disease, Crohn's Disease
The Role of Small Bowel Ultrasound in Initiation of Infliximab in Crohn's Disease Patients
Goal is to prospectively determine if stool calprotectin and change in bowel wall thickness and hyperemia, as seen on small bowel ultrasound, at week 0, 14, and 54 can be used to predict response at week 54 to infliximab in…
- Trial name
- NCT02330458
- Testing
- Small bowel ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Steatosis and Lipotoxicity
Regression of Myocardial Steatosis by Nebivolol
Within large number of patients with obesity, it is crucial to determine who is at the greatest risk for development of chronic heart disease.
- Trial name
- NCT01358409
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Lidia Szczepaniak
Cancer, Lung, Cancer Liver
PixelShine vs. Iterative Reconstruction (IR) Processing of CT Images
This study will compare the quality of CT images acquired with very low-dose radiation and processed with commercially available software vs. PixelShine processed images.
- Conditions
- Cancer, Lung, Cancer Liver, X-rays; Effects
- Trial name
- NCT03033615
- Testing
- PixelShine, Conventional processing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AlgoMedica, Inc.
Malignant Glioma
Dendritic Cell Vaccine With Imiquimod for Patients With Malignant Glioma
Malignant gliomas are very aggressive and among the most common of brain tumors. A diagnosis carries with it a median survival of approximately 24 months.
- Trial name
- NCT01792505
- Testing
- Dendritic Cell Vaccine in combination with Imiquimod cream
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Cedars-Sinai Medical Center
Kidney Transplantation
Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection
Organ transplantation offers the only hope for a normal life for patients with end-stage renal disease on dialysis (ESRD). For the highly-sensitized patient, patients with antibodies to human leukocyte antigens (HLA)…
- Trial name
- NCT01134510
- Testing
- C1 Esterase Inhibitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanley Jordan, MD
Cardiac Transplant Rejection, Qt Interval, Variation in
Home Electrocardiogram (ECG) Monitoring After Heart Transplantation
The long-term goal of this research is to apply novel technology for detection of donor organ (allograft) rejection to improve patient outcomes following heart transplantation.
- Trial name
- NEW HEART (NCT01365806)
- Where
- 3 sites in United States
- Volunteers
- 345 people
- Sponsor
- University of California, Los Angeles
Myocardial Infarction
Randomized Evaluation of Intracoronary Transplantation of Bone Marrow Stem Cells in Myocardial Infarction
This research is being done because currently there is no effective way in regenerating or replacing the heart muscle that has been damaged after a heart attack.
- Trial name
- REVITALIZE (NCT00874354)
- Testing
- Intracoronary Transplantation of Bone Marrow Stem Cells
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Cedars-Sinai Medical Center
Hypertension
Default BP Medication Intensification
High blood pressure leads to heart attacks and strokes which can be prevented by blood pressure-lowering medication. However, the current office-based prescription of one pill and one dose at a time is ineffective.
- Trial name
- NCT01994408
- Testing
- default intensification
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Allograft Vasculopathy
Angiotensin Converting Enzyme (ACE) Inhibition and Cardiac Allograft Vasculopathy
Cardiac transplantation is the ultimate treatment option for patients with end stage heart failure. Cardiac allograft vasculopathy remains a leading cause of morbidity and mortality after transplantation.
- Trial name
- NCT01078363
- Testing
- ramipril
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Stanford University
Hypertension
Sodium Healthy Living Project
Subjects will participate in a 12-week church-based intervention with five separate components: 1) participation in weekly group sessions; 2) daily use of Fitbit activity tracker; 3) daily, twice a day blood pressure monitoring…
- Trial name
- SoHELP (NCT03027791)
- Testing
- Virtual Reality, Group Sessions
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease (CMT) Infant Scale (INC-6611)
The purpose of this study is to develop and validate a clinical outcome measure to evaluate disability and disease progression of children 3 years of age and younger (infants and toddlers) with various types of…
- Trial name
- NCT02979145
- Testing
- No intervention involved
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sydney Children's Hospitals Network
Prostate Cancer
Effects of Sulforaphane on Normal Prostate Tissue
The investigators proposed to identify the biological effects of a high-sulforaphane broccoli sprout extract in normal prostate tissue.
- Trial name
- PHASE (NCT00946309)
- Testing
- High Sulforaphane Extract (Broccoli Sprout Extract)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fred Hutchinson Cancer Center
Pain, Constipation
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs.
- Conditions
- Pain, Constipation, Nausea, Vomiting
- Trial name
- NCT01114997
- Testing
- Lidocaine, Esmolol, Lidocaine + Esmolol (Combo)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Cedars-Sinai Medical Center
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Venous Thromboembolism
Prospective Study on Preoperative Versus Postoperative Venous Thromboprophylaxis in Patients Undergoing Major Colorectal Surgery
Patients undergoing major colorectal surgery are at increased risk for VTE (deep venous thrombosis) compared with patients undergoing other general surgical procedures (Bergqvist et al. Dis. Col. Rectum.
- Trial name
- NCT01976988
- Testing
- Heparin
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- Cedars-Sinai Medical Center