Clinical trials: sponsored by Aarhus University Hospital
Ankle Fracture, Recovery
Physical Recovery During Bracing After Ankle Fracture (Re-BAF)
Ankle fractures are among the most common fractures and represent the second most frequent fracture type requiring surgery. Many patients experience long-term pain, stiffness, and reduced ankle function, which substantially…
- Conditions
- Ankle Fracture, Recovery, Physical Activity, Rehabilitation
- Trial name
- Re-BAF (NCT07521696)
- Testing
- Ankle stirrup, Foot-ankle brace
- Where
- Denmark
- Volunteers
- 280 people
- Sponsor
- Odense University Hospital
Chronic Obstructive Pulmonary Disease, Emphysema
The Lung Microbiome and Endobronchial Valve Treatment
Lung emphysema is an incurable disease and is often associated with chronic obstructive pulmonary disease (COPD). Dyspnea is the main, debilitating symptom and is relieved by inhaled bronchodilators and rehabilitation.
- Trial name
- NCT04932811
- Testing
- Endobronchial valve treatment
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aarhus University Hospital
Acute Ischemic Stroke
Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE
The goal of this phase II, placebo-controlled intervention study is to investigate whether tocilizumab, an interleukin-6 (IL-6) receptor inhibitor, may have a neuroprotective effect by reducing infarct growth in adults with acute…
- Trial name
- Illuminate (NCT07870681)
- Testing
- Tociliuzumab
- Where
- 6 sites in Denmark, Norway
- Volunteers
- 156 people
- Sponsor
- Oslo University Hospital
Delirium - Postoperative, Delirium Prevention
Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery
Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications.
- Conditions
- Delirium - Postoperative, Delirium Prevention, Dexmedetomidine, Dexmedetomidine Infusion
- Trial name
- DEXLIR (NCT07867899)
- Where
- Denmark
- Volunteers
- 242 people
- Sponsor
- Peter Gaarsdal Uhrbrand
Thyroid Nodule (Diagnosis), Thyroid Cancer
Thyroid Nodule Gene Sequencing in a Danish Population
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
- Trial name
- NCT05377736
- Testing
- Molecular analyses
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Obsessive Compulsive Behavior
Digital OC Training in Children and Adolescents
The project is an interventional trial that compares digital training programs with varying levels of therapeutic contact. All participating children and adolescents will receive a digital training program following a thorough…
- Trial name
- DOT-Y (NCT07864675)
- Testing
- Digital behavioral training
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
Knee Osteoarthritis
Anatomic Congruent Prosthetic Knee Design
This double-blinded randomized control study will use kinematic and kinetic measures to compare an anatomical congruent prosthetic knee design to a standard prosthetic knee design.
- Trial name
- NCT03633201
- Testing
- Cruciate Retaining, Medial Congruent
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
External Snapping Hip, Coxa Saltans External
Progressive Resistance Training for Adults With External Snapping Hip
External snapping hip is characterised by an audible and painful snap during hip movement among physical active people around 15-40 years old.
- Trial name
- Snappy Hip (NCT06924164)
- Testing
- Progressive resistance training, Waiting time, Self guided exercise
- Where
- 13 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Oligometastatic Cancer
Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease
This prospective observational study investigates the clinical utility of circulating tumor DNA (ctDNA) in patients with oligometastatic disease (OMD) undergoing definitive-intent local ablative treatment (LAT).
- Trial name
- NCT07426250
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Intensive Care Patients, Intensive Care Unit Patients
The Intensive Care Platform Trial
Among critically ill patients, many die, and many of the survivors and their family members struggle for years with reduced quality of life. Critically ill patients are treated in intensive care units (ICUs).
- Conditions
- Intensive Care Patients, Intensive Care Unit Patients, Critical Illness
- Trial name
- INCEPT (NCT06667999)
- Testing
- Albumin, No albumin use, LMWH in weight-adjusted dose
- Where
- 40 sites in Austria, Denmark and 5 more
- Volunteers
- 10,000 people
- Sponsor
- Anders Perner
Atrial Fibrillation (AF), Obesity & Overweight
Danish Trial of Weight Loss to Reduce Atrial Fibrillation Progression
Obesity is an important risk factor for the development and progression of atrial fibrillation. Sustainable weight loss likely reduces the burden of atrial fibrillation, which has yet to be proven in adequately sized randomised…
- Trial name
- DANWRAP (NCT07816744)
- Testing
- Structured weight loss program including behavioral support and optional meal re-placement or pharmacotherapy with Glucagon-like peptide-1 receptor agonists (GLP1-RA), Standard Care (in control arm)
- Where
- 2 sites in Denmark
- Volunteers
- 480 people
- Sponsor
- Axel Brandes
COPD, Breathlessness
Reducing Breathlessness With Dronabinol in COPD Patients
This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive…
- Conditions
- COPD, Breathlessness, Cannabis
- Trial name
- BONG (NCT06473701)
- Testing
- Dronabinol 2.5mg Capsule
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Aortic Valve Stenosis, Hypertension,Essential
Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis
The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis.
- Conditions
- Aortic Valve Stenosis, Hypertension,Essential, Heart Failure
- Trial name
- BP-AVALVE (NCT04613193)
- Testing
- Blood presssure reduction
- Where
- 6 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Henrik Wiggers
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
Systemic Sclerosis (SSc)
Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis
The goal of this randomised controlled trial is to evaluate whether a partially supervised, home-based exercise programme in addition to usual care improves health-related quality of life in adults with systemic sclerosis.
- Trial name
- ScleroStrong (NCT07840430)
- Testing
- Home-based exercise programme, Usual Care
- Where
- 3 sites in Denmark
- Volunteers
- 270 people
- Sponsor
- University of Aarhus
Kidney Cancer, Renal Cell Carcinoma Metastatic
Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial
BACKGROUND: For synchronous metastatic renal cell carcinoma (RCC), surgical resection of the primary tumor in the presence of distant metastases has been the standard of therapy for select patients followed by systemic therapy.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma Metastatic, Synchronous Neoplasm
- Trial name
- NORDIC-SUN (NCT03977571)
- Testing
- Cytoreductive nephrectomy, Tissue sampling
- Where
- 11 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Niels Fristrup
Urinary Catheters, Urinary Catheterization
Effectiveness of the NowCath Foley in Reducing Catheter-Associated UTIs and Blockages in Long-Term Indwelling Catheter Users (REDUCE)
People who rely on long-term indwelling urinary (Foley) catheters often experience recurrent urinary tract infections and catheter blockages that require unscheduled catheter changes, additional antibiotics, and emergency visits.
- Conditions
- Urinary Catheters, Urinary Catheterization, Catheter-Related Infections, Catheter Associated Urinary Tract Infection
- Trial name
- REDUCE (NCT07782762)
- Testing
- NowCath Foley, Conventional All-Silicone Foley Catheter
- Where
- 3 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Nowwell AS
Tonsillitis Recurrent
Tonsillectomy Versus Tonsillotomy in the Treatment of Recurrent Acute Tonsillitis
Background: recurrent acute tonsillitis (RT) is a frequent condition affecting teenagers and adults. Patients suffer from recurring throat symptoms, fever and impaired quality of life (QOL).
- Trial name
- NCT06606262
- Testing
- Tonsillotomy, Tonsillectomy
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Tejs Ehlers Klug
Preterm, Father-Child Relations
The SUPPORTED Study - First-time Fathers of Preterm Infants.
The purpose is to support first-time fathers of premature infants in early parenthood by promoting early paternal-infant relationships.
- Trial name
- NCT06116747
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 915 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Bodily Distress Syndrome, Functional Somatic Disorder
DISTRESS Trial Functional Disorders - the DISTRESS Trial
A Diagnostic Clinic for Functional Somatic Disorders (FSD) has been set up at the outpatient diagnostic center at Regionshospitalet Silkeborg.
- Trial name
- DISTRESS (NCT06025617)
- Testing
- Diagnostic evaluation at the Diagnostic Clinic for Functional Disorders, Diagnostic as usual
- Where
- Denmark
- Volunteers
- 290 people
- Sponsor
- Regionshospitalet Silkeborg
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