Clinical trials: sponsored by IRCCS San Raffaele
Breast Cancer, Quality of Life
Toxicity and Outcome of Whole Breast Hypofractionated Radiotherapy: a Single Institution Experience
This is a homogeneous, single institution, observational, non-interventional, prospective study of 500 patients who will be treated according to the standard protocol of adjuvant hypofractionated radiotherapy after breast…
- Conditions
- Breast Cancer, Quality of Life, Radiotherapy; Adverse Effect, Dermatitis or Eczema, Survivorship
- Trial name
- Ipomammella (NCT03077191)
- Testing
- Quality of life measurement
- Where
- Italy
- Volunteers
- 410 people
- Sponsor
- IRCCS San Raffaele
Gynecologic Cancer, Radiotherapy Side Effect
Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)
This is an observational mono-institutional study. Patients with gynecologic tumors treated with advanced radiotherapy- Image Guided Radiotherapy (IGRT), Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy…
- Conditions
- Gynecologic Cancer, Radiotherapy Side Effect, Radiotherapy; Complications, Survivorship
- Trial name
- GYN-ART (NCT06306170)
- Testing
- Image Guided Radiotherapy
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Acute Myeloid Leukemia
Harnessing the Immunosuppressive Leukemic Microenvironment to Engineer T Cells With Enhanced Anti-tumor Functionality
This is a monocentric, retrospective and prospective study aimed to underline the potential of T-cell receptor (TCR)-mediated Ab recognition from the post transplant setting in acute myeloid leukemia (AML).
- Trial name
- SynT (NCT07743047)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Healthy, Parkinson Disease
Motion Capture in Box and Bloks Test
This study aims not only to develop a standardized protocol for performing the targeted BBT but also to assess synchronized parameters: kinematic (using IMUs) and electrophysiological (EMG) data.
- Conditions
- Healthy, Parkinson Disease, Stroke, Upper Extremity Paresis
- Trial name
- BBT_MOCAP (NCT07883174)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Autism Spectrum Disorder (ASD
Monitoring Daily Mobility in Children With Autism
Children with autism spectrum disorder (ASD) often show motor abnormalities and sleep disturbances that affect behavior, learning, and family quality of life.
- Trial name
- SIMBA (NCT07519369)
- Testing
- placement of a wearable wrist sensor
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Migraine Disorders
(Italian Migraine Registry, I-GRAINE-NEW)
Rationale Understanding the mechanisms and evolution of migraine is hampered by its nature as a chronic "evolutionary" condition.
- Trial name
- I-GRAINE-NEW (NCT07163416)
- Where
- Italy
- Volunteers
- 2,030 people
- Sponsor
- IRCCS San Raffaele Roma
Heart Failure
Drug Management in Heart Failure
Aim of the proposal is to create an interactive AI-based multicentre prospective database to provide information on how to improve the QoC for pts with HF.This will provide detailed information on pts characteristics,treatment…
- Trial name
- DRUM-HF (NCT06915584)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- IRCCS San Raffaele Roma
Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury
Powered Exoskeleton-Assisted Walking in Persons With Spinal Cord Injury
Spinal Cord Injury (SCI) represents a significant health challenge, particularly when it comes to the ability to walk. Among its many consequences, mobility impairment can not only directly impact quality of life but also cause a…
- Conditions
- Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury, Rehabilitation, Exoskeleton Device
- Trial name
- EKSO-SCI (NCT07884591)
- Testing
- Wearable Powered Exoskeleton
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- IRCCS San Raffaele Roma
Alzheimer Disease, Mild Cognitive Impairment
TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease
The goal of this study is to evaluate the effects of transcranial pulse stimulation (TPS) in modulating cognitive functions as well as structural and functional connectivity in individuals with mild cognitive impairment and early…
- Trial name
- TPSAlz (NCT07883148)
- Testing
- Transcranial pulse stimulation (TPS)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- IRCCS San Raffaele Roma
HSCT
Unraveling Dynamics and Clinical Impact of Tregs in Allogeneic HSCT With PTCy
This prospective and retrospective, observational, monocentric study aims to investigate the longitudinal dynamics, phenotype, and functional properties of regulatory T cells (Tregs) in patients affected by hematological…
- Trial name
- OSR_ReCARmune (NCT07883330)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ciceri Fabio
Stroke, Sabacute Stroke
Bilateral Robot-assisted Upper Extremity Rehabilitation on Motor Recovery in People With Subacute Stroke
The goal of this clinical trial is to study the clinical effects of a robotic rehabilitation treatment through a bilateral exoskeleton (Bilateral Robot-Assisted Therapy-BRAT) during standard rehabilitation, on motor recovery…
- Trial name
- BILAX (NCT06906588)
- Testing
- Experimental, Control
- Where
- 3 sites in Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease
Upper Limb Rehabilitation in People With Parkinson's Disease:
This study evaluates the effectiveness of upper limb rehabilitation using an end-effector robotic device with exercises designed to improve movements, strength, and coordination of the shoulder, elbow, and wrist in patients with…
- Trial name
- MOTORPARK (NCT06906679)
- Testing
- Experimental Group, control group
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele Roma
Hip Replacement, Total
Balance Rehabilitation Based on Serious Games
The effects of new technologies, particularly exergames, on the rehabilitation process of patients with hip arthroplasty have not yet been verified.
- Trial name
- BERTHA (NCT06908564)
- Testing
- Experimental: Interactive balance rehabilitation based on serious games., Active Comparator: conventional balance rehabilitation without the use of technological devices.
- Where
- 2 sites in Italy
- Volunteers
- 53 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke, Brain Injuries, Traumatic
Gait Training Through a Novel Over-ground Wearable Robotic System in People With Pyramidal Hemisyndromes
Over-ground exoskeletons for gait rehabilitation are studied enough in people suffering spinal cord injury, and its clinical use is escalating in the industrialized countries.
- Conditions
- Stroke, Brain Injuries, Traumatic, Brain Tumor Benign
- Trial name
- GAITGO (NCT04559724)
- Testing
- Indego Therapy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
HIV, Antiviral Agents
Antiviral Long Acting Drugs Landing in People Living With HIV
This is a monocentric, prospective, double-arm, randomized, open-label, implementation-effectiveness hybrid type III study aimed at comparing hospital-based and home-based administration of CAB LA + RPV LA treatment for…
- Trial name
- ALADDIN (NCT06468995)
- Testing
- Surveys completion, Home administration of CAB+RPV, Hospital administration of CAB+RPV
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
HIV Infections
Cohort Study of HIV-positive People, Treated With Long Acting Antiretroviral Therapy
Systematic, continuative collection of clinical and laboratory data on patients followed at lnfectious Diseases Unit of the IRCCS San Raffaele Hospital in Milan, receiving long-acting ART (Phase IV, single-center, prospective…
- Trial name
- SCohoLART (NCT05663580)
- Testing
- Cabotegravir 600mg/3mL, Rilpivirine 900mg/3mL
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Castagna Antonella
Clear Cell Renal Cell Carcinoma, VHL Syndrome
Overtaking Intra and Inter Tumoral Heterogeneity In Von Hippel-Lindau Related Renal Cancer
The goal of this study is to comprehensively map intra and inter tumor heterogeneity of ccRCC in VHL patients through the use of imaging, molecular biology and genomics techniques.
- Trial name
- ITHORinVHL (NCT06195150)
- Testing
- Blood collection
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- IRCCS San Raffaele
Stroke, Upper Extremity Paresis
The Efficacy of Upper Limb Rehabilitation With Exoskeleton in Patients With Subacute Stroke.
Loss of arm function is a common and distressing consequence of stroke. Neurotechnology-aided rehabilitation could be a promising approach to accelerate the recovery of upper limb functional impairments.
- Trial name
- PowerUPS-REHAB (NCT04697368)
- Testing
- Exoskeleton-Assisted Upper Limb Rehabilitation, Traditional Upper Limb Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele Roma
Down Syndrome, Hemiparesis
Kinematic Analysis of Manual Dexterity
The following study aims to standardize the instrumented BBT for the objective evaluation of upper limb joint kinematics using MoCap on a population of healthy subjects between 4 and 18 years of age.
- Conditions
- Down Syndrome, Hemiparesis, Healthy Subjects
- Trial name
- SUPERFUN (NCT07875127)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma