Clinical trials: sponsored by Tang-Du Hospital
Myasthenia Gravis, Generalized
The Safety and Efficacy of S103 in the Treatment of Refractory Generalized Myasthenia Gravis
This study is a single-center, open-label, single-arm, dose-exploration study to evaluate the safety and preliminary effectiveness of BCMA CAR-T（S103） in the treatment of refractory, generalized myasthenia gravis.
- Trial name
- NCT06958939
- Testing
- Dose level 1 group, Dose level 2 group, Dose level 3 group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ting Chang, MD
NSCLC (Non-small Cell Lung Cancer)
Serplulimab Monotherapy in Elderly Patients With NSCLC and PD-L1 TPS ≥ 50%
This prospective clinical study aims to evaluate and observe the efficacy and safety of Serplulimab Monotherapy in Elderly Patients with NSCLC and PD-L1 TPS ≥ 50% using a multicenter, single-arm, phase II design.
- Trial name
- NCT07596121
- Testing
- Serplulimab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Ossification of Posterior Longitudinal Ligament, Cervical Spondylosis With Myelopathy
Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
The purpose of this study is to compare the efficacy, safety and imaging outcomes between Anterior Controllable Antedisplacement and Fusion (ACAF) and Laminoplasty in the treatment of severe ossification of cervical posterior…
- Trial name
- NCT04968028
- Testing
- ACAF, Laminoplasty
- Where
- 12 sites in China
- Volunteers
- 167 people
- Sponsor
- Shanghai Changzheng Hospital
Traumatic Brain Injury, Neurocritical Care
Effect of Semi-elemental Enteral Nutrition on Gastrointestinal Tolerance in Patients With Traumatic Brain Injury.
Study Objective This clinical trial primarily aims to investigate whether semi-elemental enteral nutrition (SEN) improves gastrointestinal tolerance in patients with severe traumatic brain injury (TBI) and to evaluate its impact…
- Conditions
- Traumatic Brain Injury, Neurocritical Care, Enteral Feeding Intolerance
- Trial name
- SEMINAR (NCT07092423)
- Testing
- Semi-elemental formula, Standard formula
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Carcinoma, Non-Small-Cell Lung (NSCLC), Neoplasm Staging
Iparomlimab and Tuvonralimab Plus Chemotherapy Before Surgery for Stage III Lung Cancer
Background: For patients with resectable stage III-N2b non-small cell lung cancer (NSCLC), optimal perioperative treatment strategies remain an area of active investigation.
- Conditions
- Carcinoma, Non-Small-Cell Lung (NSCLC), Neoplasm Staging, Lymphatic Metastasis
- Trial name
- NCT07538193
- Testing
- Iparomlimab and Tuvonralimab combined with Platinum-Based Chemotherapy (Pemetrexed/Carboplatin for Non-squamous; Nab-paclitaxel/Carboplatin for Squamous)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Tang-Du Hospital
Head & Neck Cancer
Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma
This is a prospective, single-arm, Phase II clinical trial designed to evaluate the efficacy and safety of vibecotamab combined with putelimab in the treatment of locally advanced laryngeal carcinoma.
- Trial name
- NCT07538206
- Testing
- Vibecotamab Injection
- Volunteers
- 10 people
- Sponsor
- Tang-Du Hospital
Gastric Cancer (GC), Gastric Adenocarcinoma
Laparoscopic Staging for Stage III Gastric Cancer
This study aims to determine, through a multicenter randomized controlled design, the impact of precision treatment guided by laparoscopic staging on overall survival (OS), surgical conversion rate, and peritoneal metastasis rate…
- Trial name
- CGCA202501 (NCT07533825)
- Testing
- Laparoscopic Staging-Guided Therapy, Without Laparoscopic Exploration
- Where
- China
- Volunteers
- 968 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Intracerebral Hemorrhage, Stroke-Associated Pneumonia (SAP)
An Open-Label, Dose-Escalation Study on the Safety, Tolerability and Preliminary Efficacy for Preventing SAP by Intravenous Pump-Delivered Propranolol in Patients With ICH
This is an open-label, dose-escalation study on the safety, tolerability and preliminary efficacy for preventing stroke-associated pneumonia of propranolol in patients with intracerebral hemorrhage.
- Trial name
- PROCHASE-DoE (NCT07528235)
- Testing
- Intravenous Pump-Delivered Propranolol
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage/contusions.
- Trial name
- NCT06065046
- Testing
- Baricitinib 4 MG, Standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Ischemia Stroke, Thrombectomy
Intra-arterial Methylprednisolone After Endovascular Thrombectomy
The purpose of IMPACT-LVO trial is to investigate the efficacy and safety of early adjunctive intra-arterial combined with intravenous administration methylprednisolone sodium succinate after successful endovascular thrombectomy…
- Conditions
- Ischemia Stroke, Thrombectomy, Large Vessel Occlusion
- Trial name
- IMPACT-LVO (NCT07516522)
- Testing
- The methylprednisolone sodium succinate group
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Tang-Du Hospital
NSCLC (Non-small Cell Lung Cancer)
Neoadjuvant Therapy With Ensartinib Combined With Chemotherapy for ALK-positive Non - Small Cell Lung Cancer (NSCLC)
The goal of this clinical trial is to learn if Ensartinib combined with chemotherapy works as a neoadjuvant treatment for patients with stage II-IIIB (N2) ALK-positive non-small cell lung cancer (NSCLC).
- Trial name
- TD-ENSEMBLE (NCT07354061)
- Testing
- Ensartinib + Chemotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tang-Du Hospital
Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Efficacy and Safety of Fully Resorbable Sinus Drug-eluting Stents in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps After Surgery: A Prospective, Randomized Controlled Trial
This study consists of two parts evaluating the efficacy and safety of a fully degradable sinus drug-eluting stent in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP).
- Trial name
- NCT07498374
- Testing
- the fully degradable sinus stent, intranasal corticosteroids, oral corticosteroids
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Tang-Du Hospital
Infertility
Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility
The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility.
- Trial name
- NCT07494877
- Testing
- Routine Anticoagulant Therapy (Aspirin or Heparin Sodium)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tang-Du Hospital
Carotid Artery Stenosis, Cerebral Infarction
Bacteria in Atherosclerotic Plaques and Adverse Events
This study is a prospective, multicenter cohort study conducted in western China. The registry study is primarily conducted at the Department of Neurosurgery, Tangdu Hospital, with participation from the Departments of…
- Conditions
- Carotid Artery Stenosis, Cerebral Infarction, Diabetes, Bacteria
- Trial name
- NCT06935279
- Testing
- Carotid Endarterectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Alzheimer Disease, Familial Alzheimer Disease (FAD)
The Chinese Familial Alzheimer's Network
This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide.
- Trial name
- CFAN (NCT03657732)
- Where
- 65 sites in China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset
China Cognition and Aging Study
The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and…
- Conditions
- Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset, Familial Alzheimer Disease (FAD), Vascular Dementia (VaD)
- Trial name
- COAST (NCT03653156)
- Where
- 65 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Inflammatory Bowel Disease, Heart Rate Variability
Continuous HRV Monitoring for Predicting Response to Biologic Therapy in IBD
This is a prospective, multicenter, observational cohort study, which plans to enroll patients with active IBD who are scheduled to initiate IFX or VDZ treatment between October 2025 and October 2027 at Xijing Hospital, Tang-du…
- Conditions
- Inflammatory Bowel Disease, Heart Rate Variability, Biologics, Prediction
- Trial name
- NCT07475052
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Patients With Suspected Non-small Cell Lung Cancer (NSCLC) at Clinical Stage T1
Anesthesia Comparison in Early-stage Small NSCLC: A Multicenter RCT
This study is a prospective, randomized, controlled study, which intends to enroll patients with suspected early-stage NSCLC (non-small cell lung cancer) with a diameter of ≤ 3 cm as research subjects.
- Trial name
- NCT07327736
- Testing
- Non-intubated video-assisted thoracic surgery with spontaneous breathing (NIVATS)
- Volunteers
- 410 people
- Sponsor
- Tang-Du Hospital
Thymic Epithelial Tumor
Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence (CHOICE-2)
Hyperthermic intrathoracic chemotherapy (HITOC) offers a strategy to eliminate microscopic residual disease after surgical resection.
- Trial name
- NCT07383142
- Testing
- Surgery alone, Surgery+HITOC
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Squamous Cell Carcinoma, Ivonescimab
A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC
A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined with Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for Resectable, Locally Advanced Esophageal Squamous Cell Carcinoma
- Conditions
- Esophageal Squamous Cell Carcinoma, Ivonescimab, Neoadjuvant
- Trial name
- NCT07385001
- Testing
- AK112, AK112 + Neoadjuvant chemotherapy
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Tang-Du Hospital