Clinical trials: sponsored by UMC Utrecht
Colorectal Cancer Metastatic
Radioembolization in Elderly/ Fragile Patients With mCRC
Radioembolization (RE) is a minimally invasive treatment with administration of radioactive microspheres into the hepatic artery via a microcatheter.
- Trial name
- CAIRO7 (NCT05092880)
- Testing
- radioembolization, Standard of care first-line systemic therapy
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- UMC Utrecht
Metastatic Colorectal Cancer, Metastatic Cancer to Liver
FAPI Molecular Imaging for Diagnosis of the CMS4 Unfavorable Colorectal Cancer Subtype
Colorectal cancer (CRC) is the 3rd most common cancer worldwide and accounts for ~14,000 new diagnoses and ~5,000 deaths in the Netherlands yearly (1.9 million and 935 thousand on a global level).
- Trial name
- FoCus (NCT06191120)
- Testing
- [18F]-ALF-FAPI-74 PET/CT scan
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- UMC Utrecht
Circulating Tumor DNA, Recurrence
Circulating Tumor DNA Based Adjuvant Chemotherapy in Stage II Colon Cancer Patients: the MEDOCC-CrEATE Trial
Patients in the Prospective Dutch ColoRectal Cancer cohort (PLCRC) with non-metastatic colon cancer that gave consent for additional blood withdrawals are enrolled in the observational PLCRC-MEDOCC substudy.
- Conditions
- Circulating Tumor DNA, Recurrence, Colon Cancer Stage II
- Trial name
- CrEATE (NCT06434896)
- Testing
- ctDNA analysis after surgery
- Where
- 29 sites in Netherlands
- Volunteers
- 1,320 people
- Sponsor
- UMC Utrecht
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Behcet's Disease, Idiopathic Inflammatory Myopathies
Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases
Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) is limited due to small patient populations.
- Conditions
- Behcet's Disease, Idiopathic Inflammatory Myopathies, IgG4-related Disease
- Trial name
- DRIMID (NCT06285539)
- Testing
- Filgotinib
- Where
- 6 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Breast Cancer
Supplemental Screening for Women With Extremely Dense Breast Tissue: the DENSE-2 Trial
Women with extremely dense breasts (nearly all glandular and connective tissue, little fatty tissue) have a 3-6 times higher risk of breast cancer than women with very low breast density.
- Trial name
- DENSE-2 (NCT06636370)
- Testing
- Contrast-enhanced mammography (CEM), Abbreviated MRI (AB-MRI)
- Where
- Netherlands
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- C.H. van Gils
Doxorubicin Induced Cardiomyopathy, Chemotherapeutic Toxicity
Mitochondrial dysfUnction: a Key Player in Doxorubicin-induced Skeletal and Cardiac muscLE Damage
The goal of this observational study is to demonstrate the ability of using non-invasive Phosphorus (31P) Magnetic Resonance Spectroscopy (MRS) to monitor changes of in-vivo markers of mitochondrial function in skeletal and…
- Conditions
- Doxorubicin Induced Cardiomyopathy, Chemotherapeutic Toxicity, Anthracyclines
- Trial name
- MUSCLE (NCT05731375)
- Testing
- 31-MRS at 7 Tesla (T)
- Where
- 4 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Metastatic Breast Cancer
Effects of Exercise in Patients With Metastatic Breast Cancer
Currently, the effect of exercise on metastatic breast cancer has not been extensively studied, even though the benefits are evident in the curative setting.
- Trial name
- EFFECT (NCT04120298)
- Testing
- Supervised exercise
- Where
- Netherlands
- Volunteers
- 357 people
- Sponsor
- UMC Utrecht
Neoplasms
Personalized Live-remote Exercise Training for Cancer Survivors
Background Many people with cancer face ongoing problems from their disease and treatments, like fatigue, reduced physical fitness, feeling anxious or down, and neuropathy.
- Trial name
- LION (NCT06270628)
- Testing
- Exercise group
- Where
- Netherlands
- Volunteers
- 350 people
- Sponsor
- UMC Utrecht
Osteoarthritis, Knee
3D Joint Space Evaluation in Knee Osteoarthritis: The Importance of Weight-bearing and Flexion
Rationale: Osteoarthritis (OA) is mainly characterized by cartilage degeneration. In knee OA, measuring the distance between the tibia and femur, known as the joint space width (JSW), is an often-used method to quantify the…
- Trial name
- 3DJSW-MRI (NCT05950854)
- Testing
- Weight-bearing MRI
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Mylène Jansen
Cleft Palate Children, Cleft Alveolar Ridge
Alveolar Cleft Repair Using Osteoinductive Ceramics
In this study, patients with unilateral cleft lip and palate are enrolled in a multicenter stepped wedge randomized trial ithat compares alveolar cleft closure using autologous bone harvested form the mandibular symphysis with an…
- Conditions
- Cleft Palate Children, Cleft Alveolar Ridge, Cleft Lip and Palate
- Trial name
- ACROSTIC (NCT05331456)
- Testing
- Unilateral alveolar cleft repair
- Where
- 4 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- UMC Utrecht
Monoclonal Gammopathy of Uncertain Significance
Zanubrutinib Treatment in Patients With IgM Monoclonal Gammopathy and Antri-MAG Related Polyneuropathy
The objective of this investigator-initiated phase II single-arm open-label clinical trial is to investigate neurological response rate, safety and tolerability of Zanubrutinib 320 mg daily in combination with Rituximab 375 mg/m2…
- Trial name
- MAGNAZ (NCT05939037)
- Testing
- Zanubrutinib Oral Product
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Spinal Metastases
Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases
The BLEND RCT aims to evaluate the (cost-)effectiveness of same-day SBRT and surgical stabilization with or without decompression for the treatment of symptomatic, unstable spinal metastases on physical functioning four weeks…
- Trial name
- BLEND (NCT05575323)
- Testing
- Same-day SBRT and spinal surgery, Standard of care
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
GastroEsophageal Cancer, Incurable Disease
The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
The survival of patients with incurable gastroesophageal cancer can extend over a year with anticancer therapy. However, the number of patients with deteriorating quality of life in this patient group steadily decreases over time…
- Trial name
- RADICES (NCT06138223)
- Testing
- Exercise intervention, Nutrition intervention
- Where
- 22 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Breast Cancer
Cancer Of the BReast Asanas Study (COBRA)
Rationale: Women with hormone-receptor positive breast cancer are usually prescribed endocrine therapy for a period of 5-10 years. This treatment reduces the risk of recurrence and improves overall survival in these women.
- Trial name
- COBRA (NCT06480513)
- Testing
- live yoga, live remote yoga
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- UMC Utrecht
Staphylococcus Aureus Bacteremia
Staphylococcus Aureus Network Adaptive Platform Trial
The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with…
- Trial name
- SNAP (NCT05137119)
- Testing
- Cefazolin, Penicillin, Clindamycin
- Where
- 161 sites in United States, Australia and 11 more
- Volunteers
- 8,000 people
- Sponsor
- University of Melbourne
Haemophilia, Hemophilia A
Synovial Proliferation on Routine Ultrasound: Active or Inactive?
There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to…
- Conditions
- Haemophilia, Hemophilia A, Hemophilia B
- Trial name
- 2BEGIN (NCT06809972)
- Testing
- Ultrasound imaging
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Van Creveldkliniek
Recurrent Pancreatic Ductal Adenocarcinoma
Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
A randomized controlled trial, nested within an existing prospective cohort (Dutch Pancreatic Cancer Project; PACAP) according to the 'trials within cohorts' (TwiCs) design in which the effect of additional local ablative therapy…
- Trial name
- ARCADE (NCT04881487)
- Testing
- Additional stereotactic body radiation therapy
- Where
- 3 sites in Netherlands
- Volunteers
- 174 people
- Sponsor
- UMC Utrecht
Diffuse Midline Glioma, H3 K27-Altered
Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)
This study is for people (children and adults) with a rare and aggressive brain tumor called H3K27-altered diffuse midline glioma (DMG) located in the pons, a deep part of the brainstem.
- Trial name
- FIDES (NCT07562971)
- Testing
- Focused Ultrasound (FUS) Blood-Brain Barrier Opening, Temozolomide (TMZ)
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht