Clinical trials: sponsored by Duke University
Streptococcus Pyogenes Pharyngitis, Streptococcus Infection
A Strep Throat Controlled Human Infection Trial in Healthy Adults
This aim of this study is to further develop a new way to study the bacteria that causes pharyngitis (strep throat). The scientific name for this bacterium is Streptococcus pyogenes and it is commonly known as Strep A.
- Trial name
- CHIVAS-M1 (NCT06992141)
- Testing
- Streptococcus pyogenes M1UK strain MCRI0102
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Insomnia, Posttraumatic Stress Disorder
An Evaluation of Insomnia Treatment to Reduce Cardiovascular Risk in Patients With Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a chronic, debilitating psychiatric disorder that is associated with an increased risk of death due to cardiovascular disease (CVD). Most individuals with PTSD also have Insomnia Disorder.
- Conditions
- Insomnia, Posttraumatic Stress Disorder, Cardiovascular Risk Factor
- Trial name
- NCT04498754
- Testing
- Cognitive Behavior Therapy for Insomnia, Weekly phone contacts
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Fever, Adverse Event Following Immunisation
Safety of RSV Preventive Monoclonal Antibody
This is a prospective, randomized, open-label clinical trial to evaluate the safety of administration of respiratory syncytial virus (RSV) preventive monoclonal antibody and other routine childhood vaccines given simultaneously…
- Trial name
- NCT07158814
- Testing
- Respiratory Syncytial Virus (RSV) Preventive Monoclonal Antibody
- Where
- 6 sites in United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Duke University
Advanced Breast Cancer, Advanced Prostate Cancer
Engage Psychosocial Intervention for Cancer Symptoms
The goal of this clinical trial is to test the efficacy a new psychosocial symptom management intervention called ENGAGE for patients with Stage IV breast, prostate, lung, or colorectal cancer.
- Conditions
- Advanced Breast Cancer, Advanced Prostate Cancer, Advanced Lung Cancer, Advanced Colorectal Carcinoma
- Trial name
- Engage (NCT06555588)
- Testing
- ENGAGE, Supportive Care
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Duke University
Sickle Cell Disease
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-40 years…
- Trial name
- ZnSCD (NCT06260891)
- Testing
- 25 mg/day zinc, 40 mg/day zinc
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Francisco
Obesity in Pregnancy, Labor Complication
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0
Obesity increases the risk of pregnancy complications, including puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- NCT06488781
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 787 people
- Sponsor
- University of Oklahoma
Alcohol Drinking, Suicide
mHealth-supported Skills Training for Alcohol-Related Suicidality Phase 3
Suicide is a high priority public health problem and an increasingly prevalent alcohol-related consequence. One-third of people who die by suicide consume alcohol at hazardous rates in the year preceding death.
- Trial name
- mSTARS (NCT05847582)
- Testing
- Standard inpatient psychiatric care, Inpatient Skills Training, mHealth-supported Skills Training for Alcohol-Related Suicidality (mSTARS)
- Volunteers
- 35 people
- Sponsor
- Duke University
HIV/AIDS, Cardiovascular Diseases
Pathways to Cardiovascular Disease Prevention (DCRI Central and Statistical Coordinating Center)
The goal of this research is to generate evidence-based recommendations for the management of cardiovascular disease (CVD) risk in People Living with HIV (PLWH).
- Trial name
- NCT04025125
- Where
- United States
- Volunteers
- 2,039 people
- Sponsor
- Duke University
Epilepsy
Systematic Evaluation of VNS Parameters
The goal of this study is to measure the activation of the vagus nerve and the side effects of vagus nerve stimulation (VNS) (neck muscle contractions, changes in heart rate) across a range of stimulation parameters typically…
- Trial name
- NCT05395026
- Testing
- electrical stimulation of vagus nerve
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Prostate Cancer
Molecular Studies and Clinical Correlations in Human Prostatic Disease
The Genitourinary Oncology/Urology Services at Memorial Sloan-Kettering Cancer Center (MSKCC) participates in research for the control, treatment, and cure of cancer.
- Trial name
- NCT00578240
- Where
- United States
- Volunteers
- 5,290 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Uterine Cancer
Trans-Rectal Ultrasound of the Female Pelvis for Real-Time MRI-US Fusion Based Needle Tracking
The purpose of this study is to utilize transrectal ultrasound (TRUS) images of the intact and post-hysterectomy female pelvis in order to provide feasibility information for a Magnetic Resonance Imaging (MRI)-TRUS fusion based…
- Trial name
- (TRUS) (NCT05977621)
- Testing
- Transrectal ultrasound (TRUS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Cervical Cancer
Pilot Study for Speculum Free Cervical Cancer Screening
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- Calla (NCT04107181)
- Testing
- Introducer "calla" device, Interviews only
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Duke University
Autism, Autism Spectrum Disorder
SenseToKnow Autism Screening Device Validation Study
This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow device for the detection of autism spectrum disorder in children 16-36 months of age.
- Trial name
- NCT05874466
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Cancer
Cervical Cancer Detection Using Optical Spectroscopy
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- NCT00900575
- Testing
- Optical Spectroscopy Bench-Top System, Portable Optical Spectrometer, Transvaginal colposcope
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
Disruptive Behavior, Pediatrics
Tele-PCIT for Healthy Relationships in Families At-Risk
The study will examine Parent Child Interaction Therapy (PCIT) delivered via telehealth (Tele-PCIT) for young children at risk for adverse childhood experiences and/or trauma exposure.
- Trial name
- NCT07225010
- Testing
- Telehealth Parent Child Interaction Therapy, Telehealth Parent Child Interaction Therapy (Delayed Start)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Shoulder Adhesive Capsulitis, Shoulder Pain
Dry Needling for Shoulder Adhesive Capsulitis
This study evaluates the addition of dry needling to exercise as part of physical therapy for the treatment of shoulder adhesive capsulitis. There will be two groups.
- Conditions
- Shoulder Adhesive Capsulitis, Shoulder Pain, Frozen Shoulder
- Trial name
- NCT03861923
- Testing
- Dry needling, Therapeutic Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Hypophosphatasia
Natural History Study of Patients With Hypophosphatasia (HPP)
Hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by defective bone and teeth mineralization caused by mutations of the ALPL gene, which encodes for the tissue-nonspecific alkaline phosphatase (TNSALP)…
- Trial name
- NatHisHPP (NCT02237625)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Pompe Disease
Cognitive and Neurological Pathologies in Pompe Disease
The purpose of this study is to better understand the long-term health effects of Pompe disease and to determine if there are any abnormal changes in the brain and peripheral nerves.
- Trial name
- CNS (NCT04639336)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Sickle Cell Disease
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain
The investigators will conduct a hybrid type 1 effectiveness implementation trial to assess the effectiveness of acupuncture and guided relaxation on 360 people with Sickle Cell Disease (SCD), while observing and gathering…
- Trial name
- GRACE (NCT04906447)
- Testing
- Guided Relaxation, Acupuncture
- Where
- 5 sites in United States
- Volunteers
- 379 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
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