Clinical trials: sponsored by Duke University
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Parkinson Disease
Closed Loop DBS Implanted RC+S Study
This study involves patients who are already planning to have deep brain stimulation (DBS) surgery to treat the symptoms of severe Parkinson's Disease (PD). The study has two goals: 1.
- Trial name
- NCT03815656
- Testing
- STN alone, GPi alone, STN + GPi
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Dennis Turner, M.D.
Mobility, ICU
Designing a Virtual Reality Intervention to Improve Physical and Psychological Health in Intensive Care Units
The goal of this study is to explore if Virtual Reality helps patients in the cardiothoracic ICU move more and feel better. Participants will be asked to answer a survey about anxiety, depression, and loneliness.
- Conditions
- Mobility, ICU, Heart Surgery, Nursing
- Trial name
- GAMERS (NCT06797895)
- Testing
- VR assisted mobility
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Hiv, Sexual Health
Parent-focused Intervention to Reduce HIV Risk in Gay and Bisexual Adolescents
Gay and bisexual youth make up 80% of all new HIV infections among adolescents ages 14-19 in the United States, yet interventions to improve sexual health outcomes in these youth are extremely limited.
- Trial name
- NCT05852600
- Testing
- Parents and Adolescents Talking about Healthy Sexuality (PATHS), Lead with Love (LWL)
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- George Washington University
Optical Coherence Tomography of Retina
Comparative Study of High Performance Low-Cost Optical Coherence Tomography
The purpose of this study is to complete performance testing of our custom optical coherence tomography (OCT) device to verify it can deliver retinal images of similar quality to a commercial OCT device.
- Trial name
- NCT05530460
- Testing
- retinal imaging with low-cost OCT device, retinal imaging with commercial OCT device
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Duke University
ARFID, Picky Eating
Chompions! A Treatment Study for Childhood Avoidant/Restrictive Food Intake Disorder (ARFID)
Avoidant Restrictive Food Intake Disorder (ARFID) is a disorder that affects toddlers, children, adolescents, and adults. Individuals with ARFID are not able to consume an adequate amount or variety of food to a degree that it…
- Conditions
- ARFID, Picky Eating, Eating Disorders in Children
- Trial name
- NCT05105308
- Testing
- Family Assisted Diet (FAD), Feeling and Body Investigator_ARFID Division (FBI-ARFID)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Duke University
Cancer Metastatic to Lung
LiveWell: Adapted DBT Skills Training for Metastatic Lung Cancer
Patients are living longer with metastatic lung cancer (i.e., metavivors) due to therapeutic advances, but face significant challenges.
- Trial name
- NCT06464562
- Testing
- LiveWell: Adapted Dialectical Behavioral Therapy Skills Training
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Gastric Intestinal Metaplasia, Gastric Precancer
REVerse Intestinal Metaplasia in the Stomach (REVISE)
This study is designed to test the use of Pyrvinium vs placebo as a treatment for gastric intestinal metaplasia with features associated with increased risk of cancer.
- Trial name
- REVISE (NCT06590454)
- Testing
- Pyrvinium
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Katherine Garman
Falls Injury, Readmission Rates
Duke Virtual IntEgrated Workflow
This quality improvement initiative aims to evaluate the implementation, utilization, and impact of virtual care technologies and workflows being implemented at Duke University Health System (DUHS).
- Conditions
- Falls Injury, Readmission Rates, CLABSI - Central Line Associated Bloodstream Infection, Catheter Associated Urinary Tract Infection
- Trial name
- Duke VIEW (NCT07406074)
- Testing
- Co-Care
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
COVID-19, Cancer
Assessing the System for High-Intensity Evaluation During Radiotherapy During Changes in Response to COVID-19
The primary objective of this research study is to assess Radiation Oncology healthcare providers (i.e. faculty, residents and advanced practice providers (APPs) implementation and perception of telehealth for on treatment…
- Trial name
- CORONA-SHIELD (NCT04357574)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Hypertension, Rheumatoid Arthritis
Improving Hypertension Control in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a autoimmune disease associated with an increased risk of developing coronary artery disease (CAD) and premature death,.
- Trial name
- NCT05760898
- Testing
- Blood pressure intervention arm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Ocular Melanoma
Eye Plaque Brachytherapy for Ocular Melanoma
This prospective registry study will evaluate doses utilized in eye plaque brachytherapy for the treatment of ocular melanoma and their associated outcomes.
- Trial name
- PROMPT (NCT06432660)
- Testing
- Data collection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Oligometastasis, Metastatic Cancer
Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry
The purpose of this study is to provide a registry of participants in order to assess the acute adverse event rates following ablative radiotherapy for metastatic disease.
- Trial name
- NCT04085029
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Systemic Lupus Erythematosus (SLE)
Whole Health Empowerment for Endotypes of Lupus: Improving Quality of Life in SLE
For people living with people living with systemic lupus erythematosus (SLE) the symptoms with the largest impact on their quality of life - fatigue, pain, and brain fog - are not always addressed in rheumatology clinic visits.
- Trial name
- WHEEL (NCT06720584)
- Testing
- Health coach-led, online support program for people living with lupus
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry - Developmental Functional EValuation
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages
- Trial name
- NSR-DEV (NCT04337697)
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of California, San Francisco
Colorectal Cancer
Botensilimab and Balstilimab Optimization in Colorectal Cancer
This is a single-arm, interventional, pilot clinical trial. Fifteen evaluable patients will have tumor-informed ctDNA testing at baseline and start botensilimab and balstilimab treatment.
- Trial name
- BBOpCo (NCT06268015)
- Testing
- Botensilimab, Balstilimab, Oxaliplatin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nicholas DeVito, MD
Aortic Disorders
Duke Customized Aortic Aneurysm Repair With Endovascular Stent-grafts - Duke CARES Trial
The purpose of this study is to see if physician modified endovascular grafts (PMEG) can be used safely for the treatment of aortic disorders.
- Trial name
- NCT07064460
- Testing
- Physician Modified Endovascular Graft
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Chandler Long, MD
ADHD, Psychiatric Health
Preschool Attention and Sleep Support (PASS)
This study will be investigating two telehealth interventions for preschoolers with ADHD. The study is divided into two Aims. During Aim 1, caregivers of preschoolers with attention concerns, pediatric behavioral health…
- Trial name
- PASS (NCT05862727)
- Testing
- Telehealth Intervention
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Duke University
Osteoarthritis
Evaluation of Biomarkers in Human Synovial Fluid
Osteoarthritis is a condition that causes joints in the human body to deteriorate over time. This condition affects more than 250 million people around the globe.
- Trial name
- NCT02664870
- Testing
- Arthroscopy, Arthroplasty
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.