Clinical trials: not yet recruiting
Mental Health
Enlace Familiar: Supporting the Mental Health of Latino Adolescents
The goal of this clinical trial is to pilot and evaluate Enlace Familiar, a culturally responsive intervention designed to support Latino adolescents in discussing their mental health needs with caregivers or other trusted…
- Trial name
- NCT07547631
- Testing
- Enlace Familiar
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Michigan
Upper Tract Urothelial Carcinoma
Circulating Tumor DNA (ctDNA) in High Grade Upper Tract Urothelial Cancer (UTUC)
The study will evaluate the feasibility of collecting ctDNA data for UTUC patients in perioperative setting and if the data generated can help with design of future prospective trials for perioperative therapy in UTUC.
- Trial name
- NCT07793240
- Testing
- Signatera testing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Alcohol Use Disorder (AUD), Alcohol Abstinence
Investigation of the Gut-Brain Axis in Alcohol Use Disorder
A non-profit study involving patients with moderate-to-severe Alcohol Use Disorder (AUD), designed to investigate whether correcting intestinal dysbiosis through Fecal Microbiota Transplantation (FMT) from healthy abstinent…
- Trial name
- FMT-ACT (NCT07902635)
- Testing
- Fecal Microbiota Transplantation (FMT) Procedure and Cognitive Behavioral Therapy (CBT) Procedure
- Where
- Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Menopause, Menopausal Symptoms
A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-being
This study evaluates the effects of Primal Harvest's Primal Meno+ supplement on symptoms of menopause and overall well-being in females aged 40-60 who are currently menopausal and experiencing at least two menopausal symptoms.
- Conditions
- Menopause, Menopausal Symptoms, Hot Flashes, Night Sweats
- Trial name
- NCT07903480
- Testing
- Primal Meno+ Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Primal Harvest, LLC
Death, Spiritual Care
Curriculum Design and Effectiveness in Death and Spiritual Care
This study will be conducted using a randomized experimental design with a pre-test/post-test control group to determine the effectiveness of a curriculum on "Death and Spiritual Care in the Elderly"-developed for students in the…
- Conditions
- Death, Spiritual Care, Spiritual Care Education
- Trial name
- NCT07902531
- Testing
- Death and Spiritual Care Education, Control
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Alzheimer Disease
A Phase 2 Clinical Study of Simenafil Hydrochloride Tablets in the Treatment of Alzheimer's Disease
This study is a multicenter, randomized, double-Blind, placebo-controlled Phase 2 clinical study to evaluate the efficacy and safety of Simenafil Hydrochloride Tablets in the treatment of participants with Alzheimer's Disease
- Trial name
- NCT07905352
- Testing
- Simenafil Hydrochloride Tablets 2.5 mg, Simenafil Hydrochloride Tablets 5 mg, Simenafil Hydrochloride Tablets 10 mg
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Vigonvita Life Sciences
HCV Infection
Clinical Study to Evaluate the Performance of the INSTI® HCV Antibody Test for CLIA-Waived Use
multicenter prospective study to evaluate the clinical performance, usability and contrived result interpretation of the INSTI® HCV Antibody Test (INSTI HCV) with fingerstick (FS) whole blood specimens from participants with…
- Trial name
- NCT07904416
- Testing
- INSTI HCV Antibody Test
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
Anxiety, Depression
Mental Health INtervention With Digital APPlications (MIND-APP): Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps
The MIND-APP trial is a 3-arm randomized controlled trial (1:1:1 allocation) conducted fully remotely via a bespoke smartphone research platform.
- Trial name
- MIND-APP (NCT07627204)
- Testing
- Tankevirus, Grubl
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Stress Urinary Incontinence
Feasibility of Resisted Expiratory Muscle Training for Females Assigned at Birth With Stress Urinary Incontinence: A Pilot Study
The goal of this randomized pilot study is to determine whether adding expiratory muscle strength training (EMST) to standard pelvic floor muscle training (PFMT) is feasible and may help improve stress urinary incontinence (SUI)…
- Trial name
- NCT07905586
- Testing
- Pelvic floor muscle training, Expiratory muscle strength training
- Volunteers
- 24 people
- Sponsor
- Thomas Jefferson University
Acute Ischemic Stroke AIS
A Phase II/III Clinical Study of SIM0811 in the Treatment of Acute Ischemic Stroke
The study will evaluate the efficacy and safety of SIM0811 in participants with acute ischemic stroke who are present within 4.5 to 24 hours since last known well. The main questions it aims to answer are: 1.
- Trial name
- NCT07903701
- Testing
- SIM0811 Dose Level A (Phase II), SIM0811 Dose Level B (Phase II), SIM0811 Dose Level C (Phase II)
- Volunteers
- 1,092 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Stroke, Motor Dysfunction
Closed-Loop SCS-BCI for Post-Stroke Hemiplegia
This study evaluates a new closed-loop rehabilitation system for stroke survivors with arm weakness. The system combines a brain-computer interface (BCI, a special cap that reads brain signals), spinal cord stimulation (a…
- Conditions
- Stroke, Motor Dysfunction, Brain-computer Interface, Spinal Cord Stimulation (SCS)
- Trial name
- CL-SCS-BCI (NCT07903116)
- Testing
- Spinal Cord Stimulation, Non-invasive Brain-Computer Interface, Hand Exoskeleton
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Colo-rectal Cancer
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy Combined With Penpulimab and Fruquintinib for Advanced Colorectal Cancer
P (Population): Patients with advanced colorectal cancer who have failed at least two prior lines of therapy. I (Intervention): Radiotherapy, immunotherapy, and fruquintinib.
- Trial name
- PRIM-CRC3 (NCT07904130)
- Testing
- Personalized ultrafractionated stereotactic adaptive radiotherapy, Immunotherapy, Target Therapy
- Volunteers
- 32 people
- Sponsor
- West China Hospital
Cervical Spine Fractures
MALMOS Technique for Selected Subaxial Cervical Spine Fractures
This prospective study will evaluate the clinical and radiological outcomes of the MALMOS technique with neutralization H-plate fixation in patients with selected subaxial cervical spine fractures.
- Trial name
- MALMOS (NCT07905573)
- Testing
- Meshtawy's Anterior Ligamentotaxis and Miniplate Osteosynthesis (MALMOS) Technique With Neutralization H-Plate Fixation
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Plantar Fasciitis, Chronic
Radial vs Focused Shockwave Therapy for Plantar Fasciitis
The goal of this clinical trial is to learn whether focused extracorporeal shockwave therapy (ESWT) provides better outcomes than radial ESWT for adults with plantar fasciitis.
- Trial name
- NCT07827638
- Testing
- Focused Shockwave therapy, Radial shockwave therapy
- Volunteers
- 216 people
- Sponsor
- Homerton University Hospital NHS Foundation Trust
Therapeutic Communication
Culturally-Tailored AI Chatbot Simulation for Therapeutic Communication and Empathy in Psychiatric Nursing Students
Therapeutic communication and empathy are core competencies in psychiatric nursing, yet students often have limited opportunities to practise them safely with culturally realistic patients and families.
- Trial name
- AI-CHAT-PSY (NCT07905469)
- Testing
- Culturally-Tailored AI Chatbot Simulation, Instructor-Facilitated Peer Role-Play
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery.
- Conditions
- Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders, Deep Brain Stimulation
- Trial name
- NCT07903038
- Testing
- Lemborexant 5 mg, Placabo
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
Ulcerative Colitis (UC)
Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who Lost Response to 30 mg Maintenance Dose
ReCOUP is a multicenter clinical study designed to evaluate the efficacy of upadacitinib (Rinvoq®) in patients with ulcerative colitis whose disease has become active again despite maintenance treatment with upadacitinib 30 mg.
- Trial name
- ReCOUP (NCT07700446)
- Testing
- Upadacitinib
- Volunteers
- 100 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Macular Degeneration, Central Visual Impairment
Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss
Reading performance in patients with Central Vision Loss will be measured with and without missing text being remapped to different parts of the visual field in a variety of different reading tasks.
- Trial name
- NCT07216924
- Testing
- Personalised Remapping Training, RSVP personalized remappi, Reading text in the wild with remapping
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Minnesota
Food Effect in Healthy Volunteers
A Phase 1, Open-Label, Two-Stage, Food Effect Study to Assess the Safety, Tolerability, and Pharmacokinetics of EI-1071 Under Fasted or Fed Conditions in Healthy Volunteers
This is a phase 1, open-label, two-stage, sequential food effect study to evaluate the safety, tolerability, and PK of EI-1071 under fasted or fed conditions in HVs.
- Trial name
- NCT07903337
- Testing
- EI-1071
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Elixiron Immunotherapeutics Inc.
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