Clinical trials: sponsored by Duke University
Metastatic Breast Cancer
Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer
Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not always happen as early or as…
- Trial name
- TARGET-PC (NCT06795529)
- Testing
- Palliative Care Intervention, "TARGET-PC", Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Cognitive Health, mHealth Application
Cognitive Training RCT for Older Chinese Americans
The purpose of this study is to develop and pilot test a mHealth intervention for cognitive training that is culturally and linguistically relevant to older Chinese Americans
- Conditions
- Cognitive Health, mHealth Application, Experience-based Co-design, Cognitive Training
- Trial name
- NCT05355870
- Testing
- Cognitive Training Intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
Immunosuppression Management, Biomarkers / Blood
PIONEER Trial (Post-Transplant Application of TruGraf and TRAC Molecular Panel in Renal Transplant Recipients)
This is an observational, prospective, multi-center trial designed to evaluate clinical outcomes in kidney transplant recipients undergoing TruGraf and TRAC monitoring. Approximately 15 U.S. sites
- Conditions
- Immunosuppression Management, Biomarkers / Blood, Subclinical Rejection, Biopsy
- Trial name
- PIONEER (NCT07231328)
- Testing
- There is no required Intervention for this Protocol. Based on Results for TruGraf/TRAC/TRAC ID Investigators may use the results in managing subjects Immunosuppression or rule out rejection.
- Volunteers
- 600 people
- Sponsor
- Transplant Genomics, Inc.
Covid19
ACTIV-6: COVID-19 Study of Repurposed Medications
The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19.
- Trial name
- NCT04885530
- Testing
- Ivermectin, Fluvoxamine, Fluticasone
- Where
- 110 sites in United States
- Volunteers
- 10,956 people
- Sponsor
- Susanna Naggie, MD
Glioblastoma
Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
The main goal of this study is to provide foundational data to drive translational approaches for an entirely novel category of immunotherapy.
- Trial name
- LAMB-G (NCT04657146)
- Testing
- Biorepository
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Congestive Heart Failure Chronic
Eat Well Heart Failure
The purpose of this parallel pragmatic randomized controlled trial (RCT) is to evaluate the impact of Eat Well (an evidence-based 'Food is Medicine' produce prescription program) with varying levels of behavioral support on…
- Trial name
- NCT07101289
- Testing
- Personal health planning and nutritional coaching, Prescription Produce
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Duke University
Pregnancy Related, Hypertension
Testing Implementation Strategies to Support Clinic Fidelity to an Outpatient Hypertension Bundle
The goal of this clinical trial is to test an approach to improve care for pregnant and post-partum patients with high blood pressure.
- Trial name
- ACHIEVE (NCT06002165)
- Testing
- Usual Care, ACHIEVE Multi-component Implementation Strategy
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of North Carolina, Chapel Hill
Glaucoma
A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery
This is a pilot study, which will include approximately five eyes of 5 patients. This study proposes that a sustained release steroid insert (Yutiq)1 be implanted along with a glaucoma drainage device (Ahmed Glaucoma Valve (AGV)…
- Trial name
- NCT04918121
- Testing
- Yutiq 0.18 MG Drug Implant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sanjay Asrani
Bowel Dysfunction
Perioperative Tissue Penetration of Antimicrobials in Infants
This study aims to define the pharmacokinetic (PK) properties of a commonly used antibiotic to treat cIAI, metronidazole, in the intestinal wall tissue of healthy infants undergoing intestinal surgery to optimize intestinal wall…
- Trial name
- NCT04299867
- Testing
- Bowel Surgery with Metronidazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Diabetic Macular Edema, Diabetic Retinopathy
Imaging Parameters and DME Treatment Response
Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients. While anti-VEGF treatments and to a lesser extent corticosteroid and macular photocoagulation have improved outcomes in patients with DME…
- Trial name
- NCT02637245
- Testing
- No intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Adolescent and Young Adult Cancer Patient
Adolescents and Young Adults (AYAs) With Advanced Cancer
This study aims to develop and test the feasibility and acceptability of a psychosocial symptom management intervention designed to meet the unique needs of Adolescents and Young Adults (AYAs) with advanced cancer.
- Trial name
- NCT05593016
- Testing
- Symptom Management for Improved Physical and Emotional Wellbeing (SMILE), Education Control Arm
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Stem Cell Transplant
mPCST for BMT Patients
We used a small randomized controlled trial (n=36) to compare a Mobile Health Pain Coping Skills (mPCST) to Usual Treatment for patients having received hematopoietic stem cell transplant.
- Trial name
- NCT01984671
- Testing
- Mobile Pain Coping Skills Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Maternal Health, Pregnancy
Provider RCT PROMOTE
Research Aim 1: Determine the effectiveness of PROMOTE vs. usual care to increase patients' receipt of counseling about workplace accommodations and pregnancy.
- Conditions
- Maternal Health, Pregnancy, Employment
- Trial name
- NCT07126405
- Testing
- PROvider ReMote ObsTetric-Related Employment Education (PROMOTE)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Congenital Heart Disease, Single-ventricle
Ventripoint Single Ventricle Study
This study will validate a coordinate-based 3-dimensional echocardiographic technique for the assessment of cardiac size and function in children and young adults with functional single ventricles.
- Trial name
- NCT05262907
- Testing
- Transthoracic Echocardiogram or Cardiac MRI, Ventripoint Echocardiogram
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Chronic Disease
Patient Initiated Note About Goals
This is a randomized controlled trial of the Patient-Initiated Note about Goals (PING).
- Trial name
- PING (NCT05637489)
- Testing
- PING
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Other Cancer
Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly
In this research study, the investigators are working to help oncologists better serve patients by delivering more patient-centered, goal-concordant care that may improve health care delivery.
- Trial name
- ACP-PEACE (NCT03609177)
- Testing
- Clinician Communication Skills Training, Advance Care Planning (ACP) Decisions Videos Decisions Aids, Video Declarations (ViDec)
- Where
- 4 sites in United States
- Volunteers
- 13,800 people
- Sponsor
- Dana-Farber Cancer Institute
Mediastinal and Hilar Lymphadenopathy
Study of Procedural Efficiency in EBUS With Dual Versus Single NEEDLEs: Evaluating the Value of a Second Needle in EBUS as it Pertains to Economic and Environmental Impact
Currently, the EBUS bronchoscopy procedure uses either one or two needles to perform the biopsy of the lymph node based on physician preference.
- Trial name
- SPEED NEEDLE (NCT07218042)
- Testing
- We randomized patients to the two arms above; there was no specific intervention performed other than randomizing patients to one or two needles.
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- Christopher Kapp
Heart Failure
TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled.
- Trial name
- TRANSFORM-HF (NCT03296813)
- Testing
- Torsemide, Furosemide
- Where
- 60 sites in United States
- Volunteers
- 2,973 people
- Sponsor
- Duke University
Laparotomy, Colectomy
QL Block With Exparel in Colectomy
The purpose of this study is to determine if using a different type of injection of local anesthestic (pain medicine) in between the muscle layers of the abdominal wall (called a quadratus lumborum block) will improve pain…
- Trial name
- NCT03827291
- Testing
- Exparel, Thoracic epidural analgesia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
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