Clinical trials: sponsored by Duke University
Prostate Cancer, Prostate Adenocarcinoma
ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
- Trial name
- ARCTIC (NCT06141993)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Virtual Reality, Occupational Therapy
Motivating Occupational Virtual Experiences In Therapy for Kids
A rater-blinded randomized controlled trial (RCT) will be conducted to compare the efficacy of MOVE-IT use in a remotely supervised home exercise program (HEP) to usual care for recovery of upper extremity (UE) function in…
- Trial name
- MOVE-IT (NCT04510857)
- Testing
- MOVE-IT Intervention, UCT Control
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Barron Associates, Inc.
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Infections
Chlorhexidine Gluconate Bathing Education Video Among Hospitalized Patients
Chlorhexidine gluconate (CHG) bathing is an effective intervention to reduce hospitalized patient's risk of acquiring a central line-associated bloodstream infection (CLABSI).
- Trial name
- NCT06112626
- Testing
- CHG Skin Treatment Video
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Non-small Cell Lung Cancer
Phase II Clinical Trial of NIVO-IPI-TAXANE in Untreated Metastatic NSCLC
This is an open-label, non-randomized, phase II clinical research study designed to assess the safety and efficacy of nivolumab and ipilimumab in combination with paclitaxel in patients with treatment naïve NSCLC.
- Trial name
- TOP1705 (NCT03573947)
- Testing
- Nivolumab, Ipilimumab, Paclitaxel
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Jeffrey Clarke
Age Related Macular Degeneration
AREDS 2 Ancillary Spectral Domain Optical Coherence Tomography Study
The purpose of this study is to identify whether changes in age-related macular degeneration (AMD) over time as seen with spectral domain optical coherence tomography (SDOCT) imaging, can be used to predict vision loss and the…
- Trial name
- A2ASDOCT (NCT00734487)
- Where
- 4 sites in United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Duke University
Human Immunodeficiency Virus
Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults
This is a Phase I, randomized, double-blind, placebo-controlled clinical study to define the safety and immunogenicity resulting from a rapid dose-escalating vaccination schedule as compared to that of a co-administered…
- Trial name
- RV591 (NCT06205056)
- Testing
- Ad26.Mos4.HIV in CH505 TF chTrimer + ALFQ [Arm 1a], CH505 TF chTrimer + ALFQ [Arm 1a], Ad26.Mos4.HIV in CH505 TF chTrimer +ALFQ [Arm 2a]
- Where
- Uganda
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Cardiac Involvement With COVID-19
Hearts of Athletes
The Hearts of Athletes study is being conducted to determine the heart involvement with COVID-19 in athletes. This study aims to enroll any Adult (18 years of age or greater) Athlete is defined as NCAA Collegiate Athlete…
- Trial name
- NCT04736004
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Late-Onset Pompe Disease, Lysosomal Disease
High Dose Inspiratory Muscle Training in LOPD
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
- Trial name
- NCT05431127
- Testing
- IMT therapy using the Pr02 mobile device
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Duke University
Hematologic Malignancy
Survivorship Post-HCT Optimization Program
The purpose of this project is to investigate the effects of 12 weeks of high-intensity interval training (HIIT) and resistance training on several domains of health including physical function, cognitive function, mental health…
- Trial name
- S-POP (NCT05238376)
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Juvenile Idiopathic Arthritis, Rheumatoid Arthritis
Pharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With Arthritis
The purpose of this study is to learn more about how adult and children's bodies use etanercept and how bodyweight influences how well etanercept works.
- Conditions
- Juvenile Idiopathic Arthritis, Rheumatoid Arthritis, Obesity
- Trial name
- PRECISE (NCT04585711)
- Testing
- Etanercept Optimal dosing
- Where
- United States
- Sponsor
- Duke University
Consumer Behavior
Decoding the Interplay of Front-of-Pack Labels, Price, and Consumer Perceptions: Impact on Food Choices in Korea and Singapore
The global epidemic of obesity and chronic diseases has led to widespread use of front-of-package (FOP) nutrition labels. While existing research has established a link between FOP labels and consumer choices, the interplay…
- Trial name
- NCT07186270
- Testing
- Positively framed FOP labels (present versus absent) x Price (high versus low), Graded FOP labels (no label vs. high rating (grade A) vs. low rating (grade D)) x Price (average vs. premium)
- Volunteers
- 1,000 people
- Sponsor
- Duke-NUS Graduate Medical School
Primary Brain Tumor, Brain Tumor, Recurrent
Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)
The purpose of this research study is to determine if fluoxetine increases lysosomal stress in patients with recurrent IDHwt glioma by evaluating LAMP1 expression in tumor samples obtained pre-resection via biopsy and during…
- Trial name
- NCT05634707
- Testing
- Fluoxetine, Temozolomide
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Kidney Failure, Hemodialysis Fistula Thrombosis
Clopidogrel Prevention of Early Arteriovenous (AV) Fistula Thrombosis
The objective of the study is to determine whether clopidogrel reduces the early failure rate of native AV fistulae. This study was originally registered as NCT00067119 which included two protocols, this one and the GRAFT study)
- Trial name
- FISTULA (NCT03289520)
- Testing
- Clopidogrel
- Where
- 9 sites in United States
- Volunteers
- 877 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Autism Spectrum Disorder
The Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for…
- Trial name
- ABC-CT CS (NCT05294705)
- Where
- 5 sites in United States
- Volunteers
- 565 people
- Sponsor
- Yale University
Weight Loss
Food is Medicine: Pilot Study
The goal of this study is to determine whether shared medical visits also called "group visits" would be beneficial for patients who are under weight management care.
- Trial name
- NCT06797453
- Testing
- Shared Medical Visits, Full Plate Living
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Duke University
PreDiabetes, Older Adults
Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes
This research trial studies the effect of an online, live and interactive strength training program on physical function and strength in older adults with prediabetes.
- Conditions
- PreDiabetes, Older Adults, Muscle Loss, Muscle Weakness
- Trial name
- NCT05497960
- Testing
- Vivo workout
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eric Levian
Retinal Disease, Healthy Eyes
Evaluation of the Heidelberg Engineering SPECTRALIS With Flex Module for In-vivo Imaging in the Supine Position
This is a prospective clinical study conducted at one clinical site in the United States.
- Trial name
- NCT04661124
- Testing
- SPECTRALIS, SPECTRALIS with Flex Module
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Prostate Cancer
Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer
The primary goal is to prospectively estimate the median PFS of African American and Caucasian men with mCRPC taking apalutamide, abiraterone acetate, and prednisone.
- Trial name
- PANTHER (NCT03098836)
- Testing
- ARN-509, Abiraterone Acetate, Prednisone
- Where
- 14 sites in United States
- Volunteers
- 93 people
- Sponsor
- Daniel George, MD
COVID-19
PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED
The goal of this cluster randomized clinical trial is to test the efficacy of messaging interventions to increase booster vaccine uptake in adults in the emergency department(ED).
- Trial name
- PROBOOSTVAXED (NCT06156215)
- Testing
- Vaccine Messaging, Vaccine Acceptance Question
- Where
- 7 sites in United States
- Volunteers
- 919 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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