Clinical trials: sponsored by University Hospital, Lille
Critical Illness, Terminal Illness
Prospective National Survey of the Palliative Situation Among Inmates in French Prisons
PARME study had 3 objectives: To identify the specific number of incarcerated individuals with terminal illness in need of palliative care. To describe the health and penal situation of these prisoners.
- Trial name
- PARME (NCT02362295)
- Testing
- qualitative interview
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Stroke, Acute, Drug Toxicity
Outcome of Patients Treated by iv Rt-PA for Cerebral Ischaemia According to the Ratio Sc-tPA/Tc-tPA
intravenous rt-PA is effective to reduce the risk of death or dependency after ischaemic stroke. This effect is due to an early recanalization secondary to the lysis of the clot.
- Trial name
- OPHELIE (NCT01614080)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Lille
Pre Eclampsia
Study of Coagulation Activation Markers and Pre Eclampsia
The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
- Trial name
- PRESTIGE (NCT01261351)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Signet Ring Cell Carcinoma, Stomach Disease
Prognosis of Signet Ring Cells in Upper Digestive Neoplasms
Background • A major increase in incidence of signet ring cell adenocarcinomas (ADCI) of the upper digestive tract in western countries Discordant results in the literature concerning the prognosis value of the presence of signet…
- Conditions
- Signet Ring Cell Carcinoma, Stomach Disease, Oesophagus, Prognostic
- Trial name
- ADCI001 (NCT01249859)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Lille
Evaluation of Primary Prevention ICD in Real Life
Primary Prevention ICD French Registry
The indication of implantable cardioverter defibrillator (ICD) therapy for primary prevention of sudden cardiac death has been introduced later in France than in other parts of the World.
- Trial name
- DAI-PP (NCT01992458)
- Where
- France
- Volunteers
- 5,576 people
- Sponsor
- Clinique Pasteur
Hemodynamic Instability, Surgery
Effect of Intraoperative Volume Optimization on Outcome After Intrabdominal Surgery
The purpose of this study is to determine whether intraoperative goal-directed fluid management (with goal = cardiac stroke volume maximization) based on respiratory-induced pulse pressure variation monitoring may improve outcome…
- Trial name
- EVOLUTION (NCT00766519)
- Testing
- volume optimization, standard volume administration
- Where
- 6 sites in France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Lille
Mechanical Ventilation Complication, Tracheal Intubation Morbidity
Continuous Control of Polyurethane Tracheal-cuff Pressure: Efficiency of a Pneumatic Device
Underinflation and overinflation of tracheal cuff are common in intubated patients, including those intubated with polyurethane-cuffed tubes.
- Trial name
- Nosten (NCT01351259)
- Testing
- Pneumatic device, cylindrical or tapered cuff
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Schistosomiasis, Bilharziasis
Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis
The purpose of this clinical study is to evaluate safety and immunogenicity in adult healthy volunteers of the vaccine candidate against schistosomiasis named Bilhvax.
- Conditions
- Schistosomiasis, Bilharziasis, Urinary Schistosomiasis
- Trial name
- Bilhvax1a (NCT01512277)
- Testing
- rSh28GST
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Drug-naïve Patients With Parkinson's Disease, Apathy
Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi-center Study
Among the psychiatric symptoms observed in the premotor phase of Parkinson's disease (PD) and/or in "de novo" patients, apathy is relatively frequent (estimated to 23%).
- Trial name
- NCT01765257
- Testing
- AZILECT®
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Countermeasure Evaluation
Medium-term Bedrest Whey Protein (MEP)
The human being has shown that he can live and work in the space environment, but due to the lack of essential mechanical load on muscle and bone, the fluid-shift as well as alterations in the acid-base balance (mainly on account…
- Trial name
- MEP (NCT01655979)
- Testing
- Whey Protein + Potassium bicarbonate, Control
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Type 1 Diabetes, Hypoglycemia
Islet Allotransplantation With Steroid Free Immunosuppression
The restoration of endogenous insulin secretion carries significant hopes for shifting the paradigm of life long exogenous insulin therapy in selected groups of patients with type 1 diabetes(T1D).
- Conditions
- Type 1 Diabetes, Hypoglycemia, Metabolic Diseases
- Trial name
- NCT00446264
- Testing
- islet transplantation, daclizumab - sirolimus - tacrolimus
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease, Apathy
Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia
Apathy usually refers to a set of behavioural, emotional and cognitive features as a reduced interest and participation in main activities of daily life, a lack of initiative, a trend toward an early withdrawal from started…
- Conditions
- Parkinson's Disease, Apathy, no Dementia
- Trial name
- CHoPA-I (NCT00767091)
- Testing
- rivastigmine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Suicide, Attempted, Relatives
IMTAP : Impact of the Suicide Attempt on the Nearly Entourage in Term of Traumatic Stress and Medico-economic Impact
With 11.000 deaths and 150.000 attempts each year in France, the suicide represents an important public health problem. For each death by suicide, one can count 6 "direct" bereaved people and 20 people in more indirect connection…
- Trial name
- IMTAP (NCT01213797)
- Where
- 12 sites in France
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Polycystic Ovary Syndrome
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)
PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies.
- Trial name
- PERCING (NCT00378729)
- Testing
- Metformin and FSHr, Ovarian drilling by FERTILOSCOPY
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Tract Diseases, Nosocomial Infections
Impact of Antibiotic Treatment on Outcome in Patients With Ventilator-Associated Tracheobronchitis
The aim of this study is to determine whether antibiotic treatment could reduce mechanical ventilation duration in patients with nosocomial tracheobronchitis acquired under mechanical ventilation.
- Trial name
- NCT00122057
- Testing
- antibiotic treatment
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Lille
Alcoholic Hepatitis, Alcoholic Liver Disease
Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis
The treatment of severe forms of alcoholic hepatitis (AH) constitutes a major challenge for clinicians involved in the management of severe alcoholic liver disease.
- Trial name
- CorpentoxHAA (NCT01214226)
- Testing
- Pentoxifylline
- Where
- 28 sites in Belgium, France
- Volunteers
- 278 people
- Sponsor
- University Hospital, Lille
Renal Transplantation
Daclizumab Versus Thymoglobulin in Renal Transplant Recipients With High Immunological Risk
To compare renal allograft rejection rates during the first year among high-immunological risk recipients between patients who received either ATG or the anti-IL2R mAb daclizumab.
- Trial name
- TAXI (NCT00682292)
- Testing
- Thymoglobulin (ATG), Daclizumab
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Lille
Leukemia, Promyelocytic, Acute
A Randomized Trial Assessing the Roles of AraC in Newly Diagnosed APL Promyelocytic Leukemia (APL)
The first purpose of this randomized trial will be to compare the best treatment group of APL 93 trial (ATRA with early introduction of anthracycline-AraC chemotherapy, followed by 2 consolidation anthracycline-AraC courses and…
- Trial name
- NCT00591526
- Testing
- Arac
- Volunteers
- 250 people
- Sponsor
- Groupe d'etude et de travail sur les leucemies aigues promyelocytaires
Colorectal Obstruction, Left Colonic Adenocarcinoma
Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A Randomized, Controlled Study
To evaluate wether colorectal stenting carry a significant clinical advantage
- Trial name
- NCT00514332
- Testing
- stent
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Amyotrophic Lateral Sclerosis
Effects of Gastrostomy on Amyotrophic Lateral Sclerosis
Results about effects of symptomatic treatment on QoL appears conflicting in ALS patients. Moreover no clear effects of gastrotomy have be shown on survival.
- Trial name
- NCT00337402
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Clermont-Ferrand