Clinical trials: sponsored by Shirley Ryan AbilityLab
Stroke, Healthy
Effects of Vibration on Motor Function of Survivors of Chronic Stroke
The aim of this study is to evaluate how vibration of the tendons enhances arm and hand training in survivors of chronic stroke.
- Trial name
- NCT06663501
- Testing
- Assisted Motion with Enhanced Sensation training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Resilience in Persons Following Spinal Cord Injury
This study aims to quantify resilience in survivors of a spinal cord injury. The study will consist of structured interviews and self-reported surveys.
- Trial name
- NCT04544761
- Testing
- Structured Interview
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shirley Ryan AbilityLab
Multiple Sclerosis, Multiple Sclerosis-Relapsing-Remitting
Intermittent Hypoxia in Persons With Multiple Sclerosis
This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis-Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06276634
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Weakness, Muscle
EMG Training for Altering Activation Patterns After Stroke
Evaluation of a new EMG controlled game to improve hand function in chronic stroke survivors.
- Conditions
- Stroke, Weakness, Muscle, Coordination Lack
- Trial name
- NCT03619772
- Testing
- Bilateral, Unilateral
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Healthy
Effect of Intermittent Hypoxia in Healthy Individuals
The use of acute intermittent hypoxia (AIH) has been examined in animal and human studies to gain an understanding of its effect on spinal excitability and synaptic strength.
- Trial name
- NCT04691518
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Assessing Upper Extremity Function in Chronic Stroke Survivors Through Acute Intermittent Hypoxia
Here we aim to observe effects of acute intermittent hypoxia in persons who have experienced a single stroke. We have previously shown this technique to be safe and effective at increasing strength in persons with disabilities…
- Trial name
- NCT07113457
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Validation of a Spasticity Measurement Tool
The objective of this project is to investigate the validity of a handheld spasticity measurement tool against standard clinical measurements of spasticity.
- Trial name
- NCT05374174
- Testing
- Tardieu Scale for Spasticity
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Noninvasive Spinal Stimulation in Stroke
This is a randomized control trial that will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
- Trial name
- NCT03714282
- Testing
- Noninvasive spinal stimulation with gait training, Conventional gait training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Corticospinal Function After Spinal Cord Injury
The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal…
- Trial name
- NCT02451683
- Testing
- Electrophysiology Assessment of Time Domain, Electrophysiology Assessment of Location, Training with some stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Acute
Harmony Scapulohumeral Rhythm (SHR) Reliability and Efficacy Study
The purpose of this study is to assess the safety, reliability, and efficacy of the use of the Harmony Scapulohumeral Rhythm (SHR) upper extremity robotic rehabilitation system for persons with impaired functional use of one or…
- Trial name
- NCT05251077
- Testing
- Harmony SHR, Traditional Occupational Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Shirley Ryan AbilityLab
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
The Synergistic Effects of AIH and FES in Persons With MS
The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06413602
- Testing
- Acute Intermittent Hypoxia, Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population.
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06390930
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries, Traumatic
Acute Intermittent Hypoxia in Traumatic Brain Injury
This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors.
- Trial name
- AIH (NCT04890639)
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries (SCI), Spinal Cord Disease
Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing
The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI/D) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are…
- Trial name
- NCT07364773
- Testing
- Motivational Interviewing
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Shirley Ryan AbilityLab
Motor Delay, Neurodevelopmental Disorders
Wearable Sensors and Video Recordings to Monitor Motor Development
The objective of this study is to develop an automated, precise, quantitative assay for detecting atypical motor behavior and development in infants using data from wearable sensors and video recordings.
- Conditions
- Motor Delay, Neurodevelopmental Disorders, Developmental Disability
- Trial name
- NCT03770832
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries, Spinal Cord Diseases
SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training
This is a single blind, sham controlled crossover trial that will evaluate the effectiveness of acute intermittent hypoxia therapy (AIH) combined with transcutaneous (non-invasive) spinal cord stimulation on gait and balance…
- Trial name
- NCT03922802
- Testing
- Acute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait Training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation
Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users
The goal of this research is to analyze data from smartphone-based and wearable sensors, using advanced machine-learning and data-mining techniques, and to combine this information with performance-based measures…
- Trial name
- NCT03930199
- Testing
- Needs-based intervention (physical, psychological, or both)
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Parkinson Disease
Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk
The purpose of this study is to evaluate the feasibility and efficacy of a smart airbag system that detects and mitigates fall-related impact in individuals with high fall risk.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury
- Trial name
- NCT05076565
- Testing
- Airbag Belt Fall Protection System
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs.
- Trial name
- NCT03930056
- Testing
- C-Brace II, Traditional Care KAFO intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Shoulder Pain
Multimodal Treatment for Hemiplegic Shoulder Pain
Hemiplegic shoulder pain (HSP) affects up to 60% of moderate to severely impaired stroke survivors. HSP is associated with poor rehabilitation outcomes, including interference with activities of daily living (ADLs) and poor…
- Trial name
- NCT02893267
- Testing
- Peripheral Nerve Stimulation, Physical Therapy
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- MetroHealth Medical Center