Clinical trials: sponsored by Shirley Ryan AbilityLab
Stroke, Acute, Gait, Hemiplegic
Focused Intensive Repeated Stepping During Inpatient Rehabilitation Poststroke - A Quality Improvement Project
The purpose of this quality improvement project was first to monitor usual physical therapy care (types \& cardiovascular intensity of interventions and amount of stepping practice provided) and outcomes.
- Trial name
- FIRST-IN (NCT05393661)
- Testing
- inpatient physical therapy poststroke
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Indiana University
Spinal Cord Injuries or Similar Neurological Weakness
EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)
This study seeks to test the safety and efficacy of the Esko device in SCI population and in populations with similar neurological weakness to the SCI population.
- Trial name
- EKSO (NCT01701388)
- Testing
- Ekso exoskeleton
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Healthy
WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity
This study is to develop, test, and optimize a soft hip wearable robot for individuals with stroke, Parkinson's, multiple sclerosis, or older adults with no neurologic deficits.
- Trial name
- NCT07061691
- Testing
- WIM Robotic Exoskeleton
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Inpatient Stroke Recovery Using Sensors
This observational trial seeks to assess the feasibility of using non-invasive, portable, real-time body-worn sensors to continuously monitor, quantify, and interpret recovery during inpatient treatment of stroke
- Trial name
- NCT04219670
- Testing
- Wearable sensors
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Multiple Sclerosis, Fibromyalgia
Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain
The purpose of this study is to to explore the safety and efficacy of the EXOPULSE Mollii suit, a full-body electrostimulation suit, for individuals with neurological or neuromuscular conditions that cause spasticity…
- Conditions
- Multiple Sclerosis, Fibromyalgia, Neurologic Disorder, Neuromuscular Disorders
- Trial name
- NCT07132775
- Testing
- Active full-body stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait…
- Trial name
- NCT05167786
- Testing
- Noninvasive spinal stimulation with gait training, Conventional gait training, Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Shirley Ryan AbilityLab
Cardiovascular Risk Factor
South Asian Healthy Lifestyle Initiative (SAHELI)
Research show that South Asians (SA) have a high burden of Cardiovascular Disease (CVD) risk factors of which, poor diet and physical inactivity remain the major lifestyle risk factors in SA.
- Trial name
- SAHELI (NCT03336255)
- Testing
- South Asian Healthy Lifestyle Initiative (SAHELI)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy Control, Spinal Cord Injury
Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control.
- Trial name
- NCT07814313
- Testing
- CST PAS, RST PAS
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injuries
Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients
This study will investigate whether viewing and identifying meaningful shapes or images hidden within nature pictures (pareidolia) can improve motivation and engagement in rehabilitation therapy for adults with mild to moderate…
- Trial name
- NCT07867119
- Testing
- Therapeutic Benefits of Pareidolia, Active Comparator #1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Motor Delay, Infant Development
Wearable Sensor Toolkit for Infant Motor Development
The purpose of this study is to develop and test a fully automated, wireless sensor-based toolkit for infants that can capture early indicators (0-3 months) of motor deficits during activities of daily life and track motor…
- Conditions
- Motor Delay, Infant Development, Motor Development of Premature Infants, Motor Coordination or Function; Developmental Disorder
- Trial name
- NCT07866495
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Shirley Ryan AbilityLab
Prosthesis User, Prosthesis
Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis
This study is focused on optimizing methods for controlling upper-limb myoelectric prosthetic arms. If you are enrolled in this study you would be expected to visit one of the research sites for approximately 5 in-lab visits…
- Conditions
- Prosthesis User, Prosthesis, Prosthetic, Upper Limb Amputation
- Trial name
- NCT07850544
- Testing
- Condition A: Electrode Configuration, Condition B: Electrode Configuration, Condition C: Electrode Configuration
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Liberating Technologies, Inc.
Stroke
Self-Directed Upper Extremity Gaming in Inpatients With Stroke
STRIVE uses a camera mounted on the in-room TV and a connected laptop to track arm and hand movements during gameplay via markerless motion capture.
- Trial name
- NCT07806097
- Testing
- Self-Directed Therapeutic Rehab using In-room Virtual Entertainment (STRIVE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milap Sandhu
Stroke
Motor rECovery witH eArly imagiNg In STroke
This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a…
- Trial name
- MECHANIST (NCT04165616)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Prosthetic
Sensory Feedback for Touch and Proprioception With Prosthetic Limbs
Upper limb amputation is a devastating injury that leaves many thousands of typically young and active individuals in the US to rely on artificial arms and hands to help restore their lost function.
- Trial name
- NCT02189031
- Testing
- Tactor array, Bypass Tactor
- Where
- 4 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Disabled Persons
Our Peers - Empowerment and Navigational Support - Community Living (OP-ENS-CL): A Peer Navigator Intervention for Adults With Acquired Physical Disabilities
The goal of this clinical trial is to learn if a remote peer navigator intervention (OP-ENS - CL) for people with newly acquired physical disabilities returning to community living after rehabilitation improves self-reported…
- Trial name
- OP-ENS-CL (NCT06941233)
- Testing
- Our Peers - Empowerment and Navigational Support - Community Living (OP-ENS - CL)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Susan Magasi
Stroke, Acute
Progressive Abduction Loading Therapy
This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm.
- Trial name
- PRALINE (NCT04118998)
- Testing
- Abduction Loading, Supported Reaching
- Where
- 3 sites in United States
- Volunteers
- 86 people
- Sponsor
- Northwestern University
Hypoesthesia
Multimodal Haptic Feedback for Plantar Sensory Substitution
The study will explore the use of a haptic device for sensory substitution in individuals with a movement disorder that has caused loss of plantar sensation. The haptic device consists of two components.
- Trial name
- NCT06232512
- Testing
- Haptic Device
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Motor Delay, Premature Birth
Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit
Study Aims Pilot study: Due to the large recruitment goal and length of the project, the study team/PIs will evaluate the first cohort of 6-10 participants to refine study procedures and study-related materials.
- Conditions
- Motor Delay, Premature Birth, Intraventricular Hemorrhage, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05568264
- Testing
- Physical Therapy intervention
- Where
- 3 sites in United States
- Volunteers
- 222 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries (SCI)
Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI).
- Trial name
- DOSA-SCI (NCT07739992)
- Testing
- Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milap Sandhu
Essential Tremor, Healthy Individuals
Impact of Sensory Electrical Stimulation on Sensation and Tremor
The purpose of this study is to understand the acute, short-term and long-term impact of transcutaneous and/or percutaneous electrical stimulation with afferent-specific electrical stimulation (asES) on proprioception and fine…
- Trial name
- NCT06428526
- Testing
- Continuous stimulation strategy, Closed-loop stimulation strategy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab