Clinical trials: not yet recruiting
Osteopenia, Osteoporosis
Exercise and Fall Prevention for Fracture Reduction
According to the current guideline of the German Osteology Association (DVO), pharmacological treatment is a cornerstone of osteoporosis-related fracture prevention, effectively increasing bone mineral density and reducing…
- Conditions
- Osteopenia, Osteoporosis, High Fall Risk
- Trial name
- OsteoApp (NCT07897929)
- Testing
- Guideline-based home exercise training
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Wolfgang Kemmler, PhD
Obesity & Overweight, Respiratory Depression
Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs
Drug overdose is a national crisis. The primary cause of death associated with opioids is opioid-induced respiratory depression.
- Conditions
- Obesity & Overweight, Respiratory Depression, Intranasal Drug Administration, Oxytocin
- Trial name
- ORCHID (NCT07902752)
- Testing
- Intranasal Oxytocin 40 i.u.
- Volunteers
- 100 people
- Sponsor
- George Washington University
Gastric/Gastroesophageal Junction Adenocarcinoma, Oligometastatic Peritoneal Metastasis
Serplulimab, DOS and Lenvatinib Combine With PIPAC in the Oligometastatic Peritoneal Metastasis of Gastric/Gastroesophageal Junction Adenocarcinoma
This study is a prospective, multicenter, open-label, exploratory phase II clinical trial aimed at evaluating the efficacy and safety of serplulimab combined with DOS, lenvatinib, and PIPACS in patients with oligometastatic…
- Trial name
- NCT07902648
- Testing
- Serplulimab, Docetaxel, Oxaliplatin, S1, and Lenvatinib combined with PIPAC
- Volunteers
- 42 people
- Sponsor
- Fujian Cancer Hospital
Infection, Surgical Site
Povidone-Iodine and Ozonated Distilled Water Irrigation in the Management of Maxillofacial Space Infections
Maxillofacial space infections are among the most common infections encountered in oral and maxillofacial surgery and may progress to severe, life-threatening complications if not properly managed, making their treatment a…
- Trial name
- NCT07904143
- Testing
- Incision and drainage + Povidone-iodine irrigation, Incision and drainage + ozonated distilled
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Neurosyphilis
Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis
Study Objective: Neurosyphilis remains a major clinical challenge: despite standard first-line therapy with intravenous penicillin G, as recommended by international and Chinese guidelines, approximately 30% of patients have…
- Trial name
- MIN-ADD (NCT07904533)
- Testing
- Minocycline, Aqueous crystalline penicillin G
- Where
- China
- Volunteers
- 778 people
- Sponsor
- Beijing Ditan Hospital
Tear Disorder, Resectable Locally Advanced Non-Squamous NSCLC
A Prospective Trial of SFI Plus PD-1 Inhibitors and PBC in Resectable NSCLC (SFI-NSCLC)
This prospective, single-center clinical trial will enroll 30 treatment-naïve patients with locally advanced, resectable stage II-IIIA non-small cell lung cancer (NSCLC) to receive neoadjuvant Shenqi Fuzheng Injection (SFI) in…
- Trial name
- SFI-NSCLC (NCT07843251)
- Testing
- Shenqi Fuzheng Injection
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Cancer Hospital
Pre Diabetes
Effects of Mango on Insulin Sensitivity in Prediabetes
The purpose of this study is to determine whether daily mango consumption for 6 weeks can improve glucose utilization in individuals with prediabetes.
- Trial name
- MG4 (NCT07886372)
- Testing
- Mango juice, Control Beverage
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Chronic Subacromial Impingement Syndrome
Spencer vs Positional Release Techniques for Chronic Subacromial Impingement
Chronic Subacromial Impingement Syndrome (SIS) is a common musculoskeletal condition characterized by shoulder pain, reduced range of motion, impaired proprioception, and functional disability.
- Trial name
- NCT07905170
- Testing
- spencer technique, positional release technique
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Management and Technology Lahore
Hyperglycemias, Prediabetes
Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With Hyperglycemia
This study will evaluate the effects of pA1c®HI, a heat-inactivated postbiotic derived from the bacterium Pediococcus acidilactici, on blood glucose regulation and other aspects of metabolic health in adults with elevated blood…
- Trial name
- CR2027 (NCT07903870)
- Testing
- Postbiotic
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genbioma Aplicaciones SL
Non-specific Chronic Low Back Pain
Effects of Dead Bug Exercises With and Without Diaphragmatic Breathing in Patients With Chronic Non-specific Low Back Pain.
This study outlines a Randomized Clinical Trial (RCT) evaluating whether combining diaphragmatic breathing with Dead Bug exercises provides superior benefits compared to Dead Bug exercises alone for individuals suffering from…
- Trial name
- NCT07905222
- Testing
- Dead Bug Exercises with Diaphragmatic Breathing, Dead Bug Exercises Only
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- University of Management and Technology Lahore
Hepatitis B
A Study to Compare Blood Levels of Bepirovirsen and Safety Using Different Methods of Injecting in Healthy Adult Participants
This is an open-label study being done to compare two different methods of study medicine bepirovirsen is given in healthy adults.
- Trial name
- NCT07905157
- Testing
- Bepirovirsen
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients
Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disease, often compounded by obesity, that leads to serious long-term health complications.
- Trial name
- NCT07728318
- Testing
- Tirzepatide + Standard Therapy (Intervention Group), Standard Oral Antidiabetic Drugs (OADs)
- Volunteers
- 52 people
- Sponsor
- Akhtar Saeed Medical and Dental College
Post Traumatic Stress Disorder PTSD, Hazardous Alcohol Use
Multimodal Intervention for Individuals With Posttraumatic Stress Disorder (PTSD) and Hazardous Alcohol Use
This project will test the effectiveness of a stepped-care talk therapy model for patients with PTSD and Hazardous Alcohol use (HAU).
- Trial name
- NCT07903974
- Testing
- Written Exposure Therapy (WET), Clinician Supported PTSD Coach App (CS-PTSD), Phone follow up
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Sarcopenia, Obesity Type 2 Diabetes Mellitus
Sarcopenia Risk in Obese T2DM Patients
This study aims to measure handgrip strength, walking speed, and the risk of muscle wasting in obese patients who have had diabetes for 5 years or longer, and to evaluate the relationship of these measures with factors that may…
- Trial name
- NCT07905274
- Testing
- physical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bandırma Onyedi Eylül University
Anterior Cruciate Ligament Injuries, Recovery Quality
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Background: Arthroscopic anterior cruciate ligament reconstruction (ACLR) is a common orthopedic surgery. Postoperative pain, inflammatory response and opioid-related adverse events impair early recovery quality.
- Conditions
- Anterior Cruciate Ligament Injuries, Recovery Quality, Auricular Vagus Nerve Stimulation
- Trial name
- NCT07904949
- Testing
- Experimental-Active taVNS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Core Muscle Weakness, Postural Control Deficit
"CORE Training for Musculoskeletal Health: A Study on Adaptive Exercise Protocols"
This study aims to evaluate the effects of an adaptive core training protocol that integrates core stability, core strength, and high-intensity core power exercises on muscle activation, hypertrophy, balance, and quality of life.
- Conditions
- Core Muscle Weakness, Postural Control Deficit, Trunk Stability Impairment, Functional Performance Limitation
- Trial name
- RCT-EMG-US-QoL (NCT07025395)
- Testing
- - Core Training Protocol, Control Group Core Routine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ioannis Tsartsapakis
Nasopharyngeal Cancinoma (NPC)
Risk-Adapted Anlotinib and PD-L1 for Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to evaluate the efficacy and safety of a risk-adapted treatment strategy incorporating induction therapy (Gemcitabine + Cisplatin) with Anlotinib plus Benmelstobart, followed by treatment allocation…
- Trial name
- RAPID (NCT07904819)
- Testing
- Anlotinib Hydrochloride Capsules, Benmelstobart, Gemcitabine (GEM)
- Volunteers
- 214 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma, Hepatocellular Carcinoma (HCC)
Immune-Related Adverse Events and Clinical Outcomes of First-Line Immunotherapy in Egyptian Patients With Unresectable Hepatocellular Carcinoma
The goal of this observational study is to evaluate how well first-line immunotherapy works and investigate its association with immune-related adverse events (irAEs) in Egyptian adults with unresectable hepatocellular carcinoma…
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Carcinoma (HCC), Hepatocellular Carcinoma Non-Resectable, Hepatocellular Carcinoma Metastatic
- Trial name
- NCT07904494
- Testing
- Atezolizumab plus bevacizumab, Durvalumab Plus Tremelimumab
- Where
- 4 sites in Egypt
- Volunteers
- 294 people
- Sponsor
- Assiut University
Lupus Erythematosus, Systemic
CD19-Directed CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system mistakenly attacks the body's own tissues and organs.
- Trial name
- CLEVER-SLE (NCT07659704)
- Testing
- Autologous CD19-Directed CAR-T Cells Manufactured at Ribeirão Preto Blood Center
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
LGCMN, Large and Giant Congenital Melanocytic Nevi
Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults
Background: Large and giant congenital melanocytic nevi (LGCMN) are dark birthmarks (moles). They can grow to 8 inches or more across.
- Conditions
- LGCMN, Large and Giant Congenital Melanocytic Nevi, NF1, Solid Tumor
- Trial name
- NCT07891286
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
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