Clinical trials: sponsored by Duke University
Lung Cancer Metastatic
DBT for Metastatic Lung Cancer
Metastatic lung cancer patients experience significantly greater psychological distress (i.e., depression, anxiety) compared to other cancers.
- Trial name
- LiveWell (NCT04973436)
- Testing
- Dialectical Behavioral Therapy Skills Training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Heart Failure
Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)
The purpose of the OUTPATIENT-WHF study is to characterize the effectiveness of outpatient intravenous diuretic therapy as a treatment for worsening heart failure.
- Trial name
- NCT05704595
- Testing
- Initial outpatient management strategy, including outpatient IV diuretics in clinic, Initial hospitalization-based management strategy
- Where
- United States
- Sponsor
- Duke University
Type 2 Diabetes
Rural Area Pharmacist Intervention for Diabetes
The goal of the project is to inform the system leaders regarding the feasibility and utility of having an embedded telehealth-based clinical pharmacist at rural primary care practices for supportive disease management of…
- Trial name
- NCT05761886
- Testing
- telehealth-based clinical pharmacy intervention
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Wake Forest University Health Sciences
All-cause Mortality, Hospitalization
HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis
HiLo will be a pragmatic, open-label, multicenter, clinical trial with individual level randomization of ~4400 patients with ESRD undergoing in-center maintenance hemodialysis at 120-150 units maintained by two dialysis…
- Trial name
- NCT04095039
- Testing
- Hemodialysis
- Where
- 84 sites in United States
- Volunteers
- 793 people
- Sponsor
- Duke University
Diet, Healthy
Front-of-package Label Effects in Latine and Limited English Proficiency Populations
The goal of this experiment is to examine the effects of 4 types of front-of-package food labels among a sample of Latino adults.
- Trial name
- NCT06293963
- Testing
- Guideline Daily Amounts label, Interpretive text-only label, Interpretive magnifying glass icon label
- Where
- United States
- Volunteers
- 3,306 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Suicide, Suicidal Ideation
Telehealth to Reduce Suicidality and Improve HIV Care Engagement in Tanzania
The overall objectives of the proposed research are to develop a brief telehealth counseling intervention to provide support for people living with HIV and experiencing suicidal ideation, and to support HIV care engagement.
- Conditions
- Suicide, Suicidal Ideation, HIV Infections, Adherence, Medication
- Trial name
- NCT04696861
- Testing
- IDEAS for Hope, Enhanced Standard of Care (Safety Planning)
- Where
- 2 sites in Tanzania
- Volunteers
- 60 people
- Sponsor
- Duke University
Cardioversion, Atrial Fibrillation
Heart Watch Study: a Pragmatic Randomized Controlled Trial
This will be a prospective multi-center, randomized, controlled trial of 150 patients conducted to assess the impact of individual use of the Apple Watch compared to the Withings Move on patient-reported and clinical outcomes at…
- Trial name
- NCT04468321
- Testing
- Apple Watch, Withings Move
- Where
- 3 sites in United States
- Volunteers
- 105 people
- Sponsor
- Yale University
Surgery
Redesigning Pre-surgery Patient Journeys With Telehealth
Prior to surgery, patients undergo preanaesthesia assessment to ensure timely optimisation of medical conditions that could adversely impact perioperative outcomes.
- Trial name
- NCT05781789
- Testing
- Telehealth for preoperative evaluation
- Where
- Singapore
- Volunteers
- 258 people
- Sponsor
- KK Women's and Children's Hospital
Neovascular Age-Related Macular Degeneration
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (axitinib implant) in Subjects with Neovascular Age-Related Macular Degeneration
- Trial name
- NCT06223958
- Testing
- OTX-TKI (axitinib implant), Aflibercept
- Where
- 108 sites in United States, Argentina and 1 more
- Volunteers
- 344 people
- Sponsor
- Ocular Therapeutix, Inc.
Obesity, Overweight
Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care
Up to 50% of obese patients are not interested in, or ready for, weight loss. Clinical practice guidelines clearly recommend that these patients avoid gaining weight.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- D0479 (NCT03003403)
- Testing
- Intervention Program
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Duke University
Fertility Awareness, Childbearing Intentions
The Effect of Fertility Health Awareness Strategies on Fertility Knowledge and Childbearing in Young Married Couples
Singapore, like many developed countries, is experiencing low birth rates, which is coupled with increasing age at first marriage and birth.
- Trial name
- FertStart (NCT04647136)
- Testing
- Fertility Health Screening, Fertility Awareness Tools
- Where
- 2 sites in Singapore
- Volunteers
- 841 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Locally Advanced Esophageal and Gastric Cancers (EGC)
Pembrolizumab, Radiotherapy, and Chemotherapy in Neoadjuvant Treatment of Malignant Esophago-gastric Diseases (PROCEED)
This is a single-institution, prospective phase II trial with an initial safety run-in to evaluate the efficacy and safety of neoadjuvant pembrolizumab combined with chemoradiotherapy and adjuvant pembrolizumab in patients with…
- Trial name
- PROCEED (NCT03064490)
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Weight Loss, Obesity
Charge: A Text Messaging-based Weight Loss Intervention
This study evaluates different versions of a text messaging-based app for weight loss. This study will place participants to 1 of 32 experimental conditions that reflect different texting components and levels.
- Trial name
- NCT03254940
- Testing
- Charge
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Duke University
Hearing Loss
Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss
This study aims to evaluate the benefit of bilateral hearing aid use compared to a unilateral hearing aid. Patients with mild to moderate bilateral hearing loss who are considering the purchase of a commercially available hearing…
- Trial name
- NCT04739436
- Testing
- Hearing amplification
- Where
- 2 sites in United States
- Volunteers
- 278 people
- Sponsor
- Duke University
Peripheral ICC
Vascular Positioning System G4 Algorithm ECG Data Collection for Model Training Study
The objective of this study is to collect intravascular and extravascular echocardiogram (ECG) data from subjects receiving peripherally inserted central catheters (PICC) while using the Vascular Positioning System G4 and a 12…
- Trial name
- NCT05702515
- Testing
- Digital ECG Data Collection
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Teleflex
Overweight, Obesity
Pediatric Obesity Weight Evaluation Registry (POWER) Study
The main objective of this study is to establish a national pediatric obesity registry known as POWER (Pediatric Obesity Weight Evaluation Registry).
- Trial name
- POWER (NCT02121132)
- Where
- 38 sites in United States
- Volunteers
- 4,276 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiac Arrest
Vfib by ECG or Echo During Cardiac Arrest
The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm.
- Trial name
- REASON3-2021 (NCT04906252)
- Testing
- Echocardiography, Electrocardiogram (ECG)
- Where
- 6 sites in United States
- Volunteers
- 813 people
- Sponsor
- Romolo Gaspari
Organ Preservation
A Central Preservation and Assessment Service to Optimize Donor Kidney Allocation
This is a study to collect information to assess if transporting hard-to-place (HTP) donor kidneys to a central preservation and assessment facility with dedicated organ assessment capabilities increases allocation success to…
- Trial name
- OPTIMAL (NCT06263023)
- Testing
- Sub-Normothermic Machine Preservation and Assessment
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- 34 Lives, PBC
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Hereditary Hemorrhagic Telangiectasia (HHT)
Doxycycline for Hereditary Hemorrhagic Telangiectasia
This study will investigate the effectiveness of oral doxycycline for the treatment of recurrent nasal hemorrhage in Hereditary Hemorrhagic Telangiectasia (HHT) subjects.
- Trial name
- HHT (NCT03397004)
- Testing
- Doxycycline Hyclate
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto