Clinical trials: sponsored by Duke University
Long COVID, Long COVID-19
RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs…
- Conditions
- Long COVID, Long COVID-19, Long COVID19
- Trial name
- NCT05965752
- Testing
- BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE
- Where
- 24 sites in United States
- Volunteers
- 328 people
- Sponsor
- Duke University
Breast Cancer
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer
The purpose of this study is to study patients presenting with stage IV breast cancer. Stage IV means that the breast cancer has spread to another part of the body outside the breast.
- Trial name
- NCT00941759
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spinal Metastases
Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
The purpose of this study is to determine if quantitative magnetic resonance imaging (qMRI) can objectively measure changes in the tumor/vertebral body and adjacent spinal cord following stereotactic body radiation therapy (SBRT)…
- Trial name
- NCT04248543
- Testing
- qMRI with Gadoteridol contrast agent
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Urinary Bladder, Underactive
Amplifying Sensation in Underactive Bladder
The purpose of this study is to determine the influence of intravesical (bladder) electrical stimulation and intraurethral electrical stimulation on bothersome symptoms and bladder function in neurologically-intact adult women…
- Trial name
- AMPLIFY (NCT04516434)
- Testing
- Neurometer Neurotron CPT, Cystometry, Pressure-flow study
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Malaria, P. Falciparum
Permethrin-treated Baby-wraps for the Prevention of Malaria in Children
The scientific objective of this study is to test the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.
- Trial name
- NCT05391230
- Testing
- Permethrin-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malignant Glioma
Lerapolturev in Recurrent Malignant Glioma
This is a phase 2 study of lerapolturev, an oncolytic polio/rhinovirus recombinant, in adult patients with recurrent World Health Organization (WHO) grade IV malignant glioma.
- Trial name
- NCT02986178
- Testing
- lerapolturev, Lomustine
- Where
- 6 sites in United States
- Volunteers
- 121 people
- Sponsor
- Istari Oncology, Inc.
Pregnancy
Observational Maternal COVID-19 Vaccination Study
This is a prospective, observational study. During the study, pregnant women will be followed post COVID-19 vaccination. Injection-site (local) and systemic reaction data will be assessed on vaccination day and during the 7 days…
- Trial name
- NCT04826640
- Testing
- Observational
- Where
- 4 sites in United States
- Volunteers
- 146 people
- Sponsor
- Duke University
Emergency Department Waiting Room Congestion
Emergency Department Re-evaluation Software Pilot Study
This is a research study to determine a method in improving emergency department waiting room care by using new software program.
- Trial name
- NCT05831046
- Testing
- ED management software
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer
Trimodality Approach of Low Dose iOnizing Radiation With or Without Neoadjuvant Pembrolizumab and Prostatectomy for Men With Intermediate/High Risk Prostate Cancer (TALON)
This study will enroll prostate cancer patients with an unfavorable intermediate- or high-risk diagnosis. The purpose of this study is to determine whether a regimen of pembrolizumab and low dose prostate radiation or low dose…
- Trial name
- TALON (NCT04569461)
- Testing
- pembrolizumab, Low dose prostate radiation, Radical Prostatectomy
- Where
- United States
- Sponsor
- Duke University
Intracerebral Hemorrhage
Recovery and Outcomes From Stroke
The investigators will perform follow-up on 500 cases of deep and lobar intracerebral hemorrhage to perform advanced neuroimaging before 45 days post stroke, and evaluations of motor and cognitive function at baseline, 3 months…
- Trial name
- ROSE (NCT04007757)
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- State University of New York at Buffalo
Functional Abdominal Pain
Feeling and Body Investigators for Pediatric Abdominal Pain
This study will provide tools to develop and pilot an intervention for Functional Abdominal Pain (FAP) using a ten session intervention with children ages 5-8.
- Trial name
- FBI (NCT02075437)
- Testing
- Feeling and Body Investigators with Functional Abdominal Pain, Treatment Strategies
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Critical Limb Ischemia
BEST vCLI Registry
For subjects with critical limb ischemia, identify patient, physician/hospital, and geographic factors associated with variations in treatment strategies; compare treatments and outcomes, including quality of life, cost and cost…
- Trial name
- BEST (NCT04191746)
- Where
- United States
- Volunteers
- 1,009 people
- Sponsor
- Duke University
Autism Spectrum Disorder
ABC-CT Pre-School Feasibility Study
This is a multicenter study that aims to determine whether the EEG and ET experiments studied in the ABC-CT Phase 1 and ABC-CT Confirmation studies can be successfully used with 3-5-year-old children and to determine the…
- Trial name
- NCT06413316
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Emotional Distress, Anxiety
Five Session Unified Protocol for Older Adults With Emotional Distress and Reduced Mobility
Research suggests older adults report wide-ranging emotional distress (e.g., symptoms of anxiety, depression) that negatively impacts their physical and mental health and is associated with a reduction in daily activity.
- Conditions
- Emotional Distress, Anxiety, Depression
- Trial name
- NCT04837521
- Testing
- Unified Protocol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
COPD, Anxiety
Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)
Objective: Determine whether treatment of perceived stress, anxiety, and depression with anti-depressant therapy improves dyspnea scores, 6-minute walk (6MW) distance and quality of life (QoL) in patients with Chronic Obstructive…
- Conditions
- COPD, Anxiety, Depression, Stress
- Trial name
- SAD-COPD (NCT02813447)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Congenital Heart Disease
Partial Heart Transplantation
The purpose of this study is to determine if a partial heart transplantation in patients with congenital heart disease is safe and feasible.
- Trial name
- NCT06055556
- Testing
- Partial Heart Transplantation, Freshly procured valve
- Where
- United States
- Sponsor
- Duke University
Cancer, Young Adult
Symptom Management for YA Cancer Survivors
Symptom interference is common for survivors of young adult cancer (aged 18-39 at diagnosis) and impacts their abilities to achieve normative life goals (e.g., education, careers, independence, romantic/social relationships) as…
- Conditions
- Cancer, Young Adult, Pain, Psychological Distress
- Trial name
- NCT04035447
- Testing
- Behavioral Symptom Management for Young Adult Cancer Survivors
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Depression
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Depression Trial)
This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Trial name
- ADOPT PGx (NCT05966155)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 14 sites in United States
- Volunteers
- 1,572 people
- Sponsor
- Duke University
Low Back Pain, Veterans Family
Improving Veteran Access to Integrated Management of Back Pain
The purpose and objective of this pragmatic trial is to examine the effectiveness of two different quality improvement care pathways for low back pain (LBP); a sequenced, integrated care pathway (ICP) and 2) a coordinated, care…
- Trial name
- AIM-BACK (NCT04411420)
- Testing
- Pain modulation with physical pain treatment, Telephone delivered self-management counseling for increasing physical activity, Telephone delivered behavioral treatment for participants with high risk for continued disability
- Where
- United States
- Volunteers
- 1,817 people
- Sponsor
- Duke University
Weight Loss Maintenance
Enhancing Physical Function in the Long-term for Older Adults
The intervention being studied is a 12-week nutrition and physical activity intervention, delivered using videoconference technology by registered dietitian clinicians to maintain weight loss and functional gains in older adults…
- Trial name
- NCT04490356
- Testing
- Legacy Intervention
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
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