Clinical trials: sponsored by Georgetown University
Immunosuppression Management, Biomarkers / Blood
PIONEER Trial (Post-Transplant Application of TruGraf and TRAC Molecular Panel in Renal Transplant Recipients)
This is an observational, prospective, multi-center trial designed to evaluate clinical outcomes in kidney transplant recipients undergoing TruGraf and TRAC monitoring. Approximately 15 U.S. sites
- Conditions
- Immunosuppression Management, Biomarkers / Blood, Subclinical Rejection, Biopsy
- Trial name
- PIONEER (NCT07231328)
- Testing
- There is no required Intervention for this Protocol. Based on Results for TruGraf/TRAC/TRAC ID Investigators may use the results in managing subjects Immunosuppression or rule out rejection.
- Volunteers
- 600 people
- Sponsor
- Transplant Genomics, Inc.
Metastatic Pancreatic Cancer
ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer
People are being asked to participate in this study who have metastatic pancreatic cancer (cancer that has spread to other parts of the body).
- Trial name
- NCT01489865
- Testing
- ABT-888, mFOLFOX-6
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Georgetown University
BRCA1 Mutation, BRCA2 Mutation
Genetic Education in BRCA Families
The primary goal of this research is to test a web-based genetic education intervention that is designed to educate men and women from hereditary cancer families about the personal relevance of genetic testing in order to help…
- Trial name
- NCT03544983
- Testing
- Web + Streamlined Telephone Genetic Information
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Georgetown University
Hereditary Cancer, Genetic Testing
Addressing Genomic Disparities in Cancer Survivors
The goal of this observational study is to increase genetic education and genetic testing for hereditary cancer risk among Black cancer survivors. The study will: 1.
- Trial name
- NCT06073626
- Testing
- Relational agent (RA) / Chatbot, Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Tobacco Use in Persons Living With HIV
A Trial of Positively Smoke Free Group Therapy for HIV-infected Smokers
The purpose of this study is to determine whether Positively Smoke Free group therapy is more effective at promoting cessation than standard care.
- Trial name
- NCT02072772
- Testing
- Positively Smoke Free group treatment, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- Montefiore Medical Center
Stress, Diabetes Mellitus, Type 2
Decreasing Stress in Diabetes
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared to an active control Stress Management…
- Conditions
- Stress, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- De-Stress (NCT04016415)
- Testing
- Mindfulness Based Stress Reduction, Stress Management Education
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Milton S. Hershey Medical Center
Peripheral Neuropathy, Monoclonal Gammopathy of Undetermined Significance
Daratumumab for Polyneuropathy Associated With MGUS
The goal of this clinical trial is to learn about daratumumab and hyaluronidase-fihj in patients with monoclonal gammopathy of undetermined significant (MGUS) who have been diagnosed with peripheral neuropathy suspected to be…
- Trial name
- Dara-MGUS (NCT06046287)
- Testing
- Daratumumab and hyaluronidase-fihj
- Where
- 2 sites in United States
- Sponsor
- Georgetown University
Breast Neoplasm Female, Early Detection of Cancer
The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI
The purpose of this study is to test the impact of a multilevel decision support intervention on informed decisions about breast MRI among high-risk Black and Latina women.
- Conditions
- Breast Neoplasm Female, Early Detection of Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT06892275
- Testing
- Enhanced Usual Care, Decision Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Georgetown University
DCIS
Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery
This is a feasibility study which will evaluate the effects of pre-operative treatment of DCIS of the breast with palbociclib. Patients with biopsy-proven DCIS are eligible for the study.
- Trial name
- WI223281 (NCT03535506)
- Testing
- Palbociclib
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Georgetown University
S. Aureus Transmission, Surgical Site Infection
Reducing Perioperative S. Aureus Transmission Via OR PathTrac
Healthcare-associated infections (HAIs) occur frequently and are associated with patient harm. It is important that healthcare facilities take the necessary steps to prevent the spread of resistant bacteria.
- Trial name
- NCT04657185
- Testing
- OR PathTrac Feedback Optimization
- Where
- United States
- Volunteers
- 804 people
- Sponsor
- Georgetown University
Metastatic Breast Cancer, Leptomeningeal Disease
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
A phase 2 non-randomized study to assess the safety and efficacy of the combination of tucatinib and trastuzumab with capecitabine for the treatment of leptomeningeal metastases in HER2-neu positive breast cancer.
- Trial name
- NCT03501979
- Testing
- Tucatinib, Trastuzumab, Capecitabine
- Where
- 9 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Alabama at Birmingham
Stage II-III Non-small Cell Lung Cancer
Real World Stage II-III NSCLC Patients Receiving Neoadjuvant Chemo-immunotherapy and no Surgical Resection
Neoadjuvant chemo-immunotherapy, with or without adjuvant immunotherapy, is currently the standard of care for resectable stage II-III NSCLC.
- Trial name
- NoSurgery (NCT07131163)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Parenting
Connect to Baby: A Pilot Study of a Parenting and Coparenting Program
The proposed project is a randomized control trial to assess a novel 6-session parenting and coparenting intervention for low-income parents of infants.
- Trial name
- CTB (NCT06179576)
- Testing
- Connect to Baby
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Georgetown University
HIV Infection
Observational Study of HIV+ Deceased Donor Transplant for HIV+ Recipients
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02602262
- Testing
- HIV-infected deceased donor organ
- Where
- 18 sites in United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University
Refractory Follicular Lymphoma, Relapsed Follicular Lymphoma
Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma
This is a phase I/II study in which patients will be enrolled in a standard 3+3 design. Once the maximum tolerated dose (MTD) is determined amongst patients with relapsed or refractory grade 1-3a follicular lymphoma, there will…
- Trial name
- NCT02956382
- Testing
- Ibrutinib, Venetoclax
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Georgetown University
Breast Cancer
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer
The purpose of this study is to study patients presenting with stage IV breast cancer. Stage IV means that the breast cancer has spread to another part of the body outside the breast.
- Trial name
- NCT00941759
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Kidney Diseases, Genetic Predisposition
APOL1 Genetic Testing Program for Living Donors, Part 2
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Trial name
- NCT04999436
- Testing
- APOL1 Counseling Training Program
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Northwestern University
Locally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma
Eryaspase With Modified FOLFIRINOX in Advanced Pancreatic Ductal Adenocarcinoma
This will be a single-arm, multi-center, open-label phase 1 study. The standard 3+3 design will be used to determine the maximum tolerated dose (MTD) from 4 possible dose levels of Eryaspase in combination with mFOLFIRINOX.
- Trial name
- NCT04292743
- Testing
- Eryaspase, FOLFIRINOX
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Georgetown University
Distress, Psychological, Depression - Major Depressive Disorder
Relief From Stress Via Social Protection in Senegal
Despite the growing prevalence of mental health disorders in low- and middle-income countries, significant barriers to seeking and accessing mental health services persist.
- Conditions
- Distress, Psychological, Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
- Trial name
- RESTORE (NCT06698471)
- Testing
- Community worker training, Referral to Health System
- Where
- Senegal
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Density, Breast Cancer Female
ENGAGED 2 Study: Experiences With Mammography Screening and Breast Density 2
This trial will test a decision support web based intervention for women at increased risk for breast cancer due to breast density and other risk factors (age, race/ethnicity, family history of breast cancer, history of prior…
- Trial name
- NCT03029286
- Testing
- Usual Care Arm, Personalized Web Intervention Arm
- Where
- United States
- Volunteers
- 995 people
- Sponsor
- Georgetown University