Clinical trials: sponsored by Georgetown University
Migraine
Dietary Intervention for Migraine Relief
The goal of this clinical trial is to evaluate whether a low-glutamate diet can improve migraine symptoms in adults with migraine and to explore possible biological changes associated with dietary improvement.
- Trial name
- NCT07360405
- Testing
- Dietary training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- American University
Hematologic Malignancy, Stem Cell Transplant
Mosaic Trial for Stem Cell Transplant Recipients
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared…
- Conditions
- Hematologic Malignancy, Stem Cell Transplant, Bone Marrow Transplant, Leukemia
- Trial name
- Mosaic (NCT06960993)
- Testing
- Intervention website, Enhanced Usual Care (Control) Website
- Where
- 3 sites in United States
- Volunteers
- 356 people
- Sponsor
- Northwestern University
Rett Syndrome
Technology-supported Motor Rehabilitation for People With Rett Syndrome
This study focuses on improving purposeful arm use while simultaneously reducing engagement in stereotypies. It is typically expected that the training period for this study will last about 6 months.
- Trial name
- TeMoRett (NCT07418905)
- Testing
- computer gaming
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Georgetown University
Rett Syndrome
Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing…
- Trial name
- NCT05012475
- Testing
- Modified Virtual Reality Gaming
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgetown University
Advanced Biliary Tract Cancer
NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer
This is a study to evaluate the clinical activity of the combination of fluorouracil, leucovorin, and nanoliposomal irinotecan as second-line treatment in patients with advanced biliary tract cancers following gemcitabine and…
- Trial name
- NCT04005339
- Testing
- Nanoliposomal Irinotecan, Leucovorin, Fluorouracil
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Georgetown University
Insomnia
Assessing the Feasibility of Web-based Insomnia Treatment Among Prostate Cancer Survivors
This pilot study will recruit Black/African American prostate cancer survivors into a clinical trial and will randomize each person to 1 of 2 possible treatments - an internet-based treatment for insomnia called Sleep Healthy…
- Trial name
- SIESTA-P (NCT07128927)
- Testing
- Sleep Healthy Using the Internet (SHUTi), Patient education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgetown University
Childhood Cancer, Survivorship
A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship
More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but <20% receive recommended survivorship care offered at cancer center survivorship clinics.
- Conditions
- Childhood Cancer, Survivorship, Health Care Utilization, Health Knowledge, Attitudes, Practice
- Trial name
- BRIDGES (NCT05448560)
- Testing
- Multi-level Intervention of shared model of survivorship care, Comparison Group
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Georgetown University
Social Determinants of Health, Breast Cancer
Social Risk Factors and Discrimination in Cancer Survivorship
The objective of the proposed study is to scale social risk factor screening and referral for cancer survivors and to solidify information exchange between clinical and community settings in order to improve survivor health and…
- Conditions
- Social Determinants of Health, Breast Cancer, Prostate Cancer, Health Equity
- Trial name
- NCT05301114
- Testing
- Community Health Worker support
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Medstar Health Research Institute
Ovarian Cancer Stage IV, Ovarian Cancer Stage III
A Combination Therapy Strategy to Prevent Anti-PD-1 Therapy Resistance in Metastatic Ovarian Cancer Patients
This is an open label, non-randomized, 2-stage phase II, single arm study to determine the efficacy of New York esophageal squamous cell carcinoma 1 (NY-ESO-1) peptide vaccine as a priming mechanism to prevent anti-PD1 resistance…
- Conditions
- Ovarian Cancer Stage IV, Ovarian Cancer Stage III, Ovarian Cancer Stage 3
- Trial name
- NCT05479045
- Testing
- NY-ESO-1 Peptide vaccine, Toripalimab-tpzi
- Sponsor
- Georgetown University
High Grade Gliomas, Glioblastoma
Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well.
- Conditions
- High Grade Gliomas, Glioblastoma, Astrocytoma, Oligodendroglioma
- Trial name
- PRC (NCT07439172)
- Testing
- Pre-radiation temozolomide.
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cooper Health System
Spirometry
The INTERvening for LUNG Health Trial
This research study is being done to find out whether a community health volunteer-delivered, multi-component program can improve lung health for people at risk of chronic respiratory diseases (such as asthma or COPD) in…
- Trial name
- INTERLUNG (NCT07540000)
- Testing
- Community health worker-delivered multi-component respiratory health intervention
- Where
- 2 sites in United States, Nepal
- Volunteers
- 800 people
- Sponsor
- Johns Hopkins University
Lung Cancer
A Patient and Provider Intervention to Address Health Disparities in Lung Cancer Screening
To test the impact of a multilevel intervention on primary (provider-patient communication, intentions, and knowledge) and secondary (screening referrals and completion) outcomes.
- Trial name
- NCT04675476
- Testing
- Provider Prompt & Patient Outreach and Education
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Colon Adenocarcinoma, Rectal Adenocarcinoma
Evaluating Novel Therapies in ctDNA Positive GI Cancers
This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric, PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall…
- Conditions
- Colon Adenocarcinoma, Rectal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma
- Trial name
- MRD-GI (NCT05482516)
- Testing
- Atezolizumab, Bevacizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Non-small Cell Lung Cancer Stage III
Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node or Other High Risk Features
The goal of this clinical trial is to learn about neoadjuvant cemiplimab with histology-specific chemotherapy followed by resection and adjuvant cemiplimab in stage 3 non-small cell lung cancer (NSCLC) with select N3 lymph node…
- Trial name
- NEO-SURG (NCT06449313)
- Testing
- Cemiplimab-Rwlc
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Georgetown University
Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
RISK-ADAPT Protocol in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
This is a prospective, interventional, non-randomized, phase 2 study to assess oncologic outcomes of metastatic hormone-sensitive prostate cancer (mCSPC) patients who receive a risk-adapted treatment approach followed by…
- Trial name
- RISK-ADAPT (NCT07645326)
- Testing
- Androgen Deprivation Therapy (ADT), Androgen Receptor Pathway Inhibitor (ARPI), Prostate Radiation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Georgetown University
Gulf War Syndrome, Gulf War Illness
Confirmation of Diet as a Treatment for Gulf War Illness
This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention.
- Trial name
- NCT05675878
- Testing
- Dietary Intervention
- Where
- 3 sites in United States
- Volunteers
- 111 people
- Sponsor
- American University
Hepatitis E
Seroprevalence of Hepatitis E in People With an Organ Transplant
Background: The hepatitis E virus causes an acute hepatitis that usually goes away by itself. Researchers in France studied people who received a liver or kidney transplant.
- Trial name
- NCT02190253
- Where
- 3 sites in United States
- Volunteers
- 447 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Nonsmall Cell Lung Cancer Stage
SBRT for Ultra-Central NonSmall Cell Lung Cancer
The goal of this clinical trial is to find out if Five-fraction CyberKnife stereotactic body radiation therapy (SBRT) with real-time Synchrony® motion tracking can treat ultra-central nonsmall cell lung cancer while reducing the…
- Trial name
- STELLAR IIT (NCT07852247)
- Testing
- SBRT
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Georgetown University
Spinal Stenosis Cervical, Radiculopathy, Cervical Region
Hard Cervical Collar Use Following Posterior Cervical Fusion
Postoperative immobilization with a hard cervical collar following posterior cervical fusion remains common practice despite limited evidence demonstrating improved clinical outcomes.
- Conditions
- Spinal Stenosis Cervical, Radiculopathy, Cervical Region, Posterior Cervical Fusion, Spondylosis, Cervical
- Trial name
- NCT07789288
- Testing
- Hard Cervical Collar
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Georgetown University
Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Adenocarcinoma
Gemcitabine, Cisplatin and Nab-Paclitaxel as Neoadjuvant Treatment for Patients With Resectable or Borderline Resectable Pancreatic Cancer
This phase II trial tests how well gemcitabine, cisplatin and nab-paclitaxel given before surgery (neoadjuvant) works in treating patients with pancreatic cancer that can be removed by surgery (resectable) or that is borderline…
- Conditions
- Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Adenocarcinoma, Stage I Pancreatic Cancer AJCC v8, Stage II Pancreatic Cancer AJCC v8
- Trial name
- NCT06423326
- Testing
- Biopsy, Biospecimen Collection, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Georgetown University