Clinical trials: sponsored by Shirley Ryan AbilityLab
Spinal Cord Injuries
Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
Currently, there are a variety of approaches utilized in attempts to improve upper extremity function, including: traditional therapy, neuroprostheses, botulinum toxin injections, or surgical interventions.
- Trial name
- NCT03643770
- Testing
- Upper extremity training/Armeo Spring
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to…
- Trial name
- NCT07223710
- Testing
- Paired Associative Stimulation, Locomotor Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury, Traumatic Brain Injury (TBI)
Spinal Stimulation and Gait Training to Improve Mobility in TBI
The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI), Hemiplegia and Hemiparesis
- Trial name
- DOD SS (NCT06886152)
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Stroke, Acute Stroke
Soft Exosuits for Functional Gait Recovery in Acute Stroke Rehabilitation
The purpose of this study is to develop and evaluate the use of soft exosuits in patients post stroke.
- Trial name
- NCT06231511
- Testing
- Hip flexion soft exosuit, ReWalk ReStore soft exosuit, Conventional physical therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Shirley Ryan AbilityLab
Upper Limb Hemiparesis Following Stroke
Transcutaneous Electrical Stimulation for Stroke Patients
This study aims to evaluate the feasibility and impact of transcutaneous electrical stimulation of the spinal cord (TESS) on the recovery of post-stroke individuals who have upper limb hemiparesis.
- Trial name
- NCT06950593
- Testing
- Task Specific Training (TST), Transcutaneous electrical spinal cord stimulation (TESS)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Healthy
Lower Limb ExoNET: Development and Evaluation for Gait Assistance With Stroke Survivors
Stroke-related gait impairments, such as poor limb coordination, imbalance, and reduced push-off strength, are often addressed using robotic systems or electrical stimulation, which can be costly, invasive, or insufficient for…
- Trial name
- NCT06999213
- Testing
- Assist, Resist, Slack
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
A Multi-Center Clinical Trial in Individuals With Spinal Cord Injury
The overall objective of this project is to investigate the effectiveness of daily acute intermittent hypoxia therapy (dAIH), coupled with massed practice training, to improve upper-extremity function in individuals with chronic…
- Trial name
- HANDS (NCT03644277)
- Testing
- Acute Intermitted Hypoxia, Massed Practise, Rapael Glove
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Self-Catheterization Mirror System for Female Patients
The purpose of this study is to test a modified mirror system for female patients to use during self-catheterization.
- Trial name
- NCT05406258
- Testing
- Modified Self-Catheterization Mirror, Standard Self-Catheterization Mirror
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Shirley Ryan AbilityLab
Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist
Functional Importance of a Powered Multifunction Wrist Protocol
The focus of this study is to conduct a clinical study in individuals with transradial amputations to compare function using a 1-DOF or 2-DOF wrist.
- Conditions
- Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Amputation, Amputation; Traumatic, Limb
- Trial name
- NCT04069793
- Testing
- Commercially available device, Non FDA registered device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy, Contracture
Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy
In this controlled dose-escalation study, we will study the initial safety, biological properties, and potential efficacy of 5-azacytidine (AZA).
- Trial name
- NCT06377085
- Testing
- 5-Azacytidine 10mg/m^2
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Osteoarthritis, Knee Osteoarthritis
Impact of Different Exercise Programs on Knee OA
This study will examine and compare the changes in serum biomarkers, joint kinematics, and thigh muscle strength based on three different 8-week exercise protocols in individuals with knee pathology: Lower-body positive-pressure…
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases
- Trial name
- NCT05844124
- Testing
- Exercise for Knee Osteoarthritis Recommendations (Control group), Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking), Exercise for Knee Osteoarthritis - (Aquatic Walking)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Limb Deficiencies
Assessing the DSR Ankle
This research is being done to conduct a preliminary investigation into a new prosthetic microprocessor controlled (MPC) ankle, called the Damping, Stiffness, and Repositioning (DSR) ankle.
- Trial name
- NCT05955378
- Testing
- DSR Ankle, Predicate Ankle
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Synchro Motion LLC
Amputation, Amputation, Traumatic
Neuromusculoskeletal Interface for Bionic Arms
The overall objective of this proposal is to perform a first-in-human home trial of the Electronic Osseoanchored Prostheses for the Rehabilitation of Amputees (e-OPRA) implant system in individuals with transhumeral amputations…
- Conditions
- Amputation, Amputation, Traumatic, Amputation, Surgical, Upper Limb Amputation Above Elbow (Injury)
- Trial name
- NCT07032753
- Testing
- eOPRA, OPRA, eOPRA with sensory feedback
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Amputation; Traumatic, Limb
Low Cost Socket for Lower Limb Amputees
The purpose of this research is to test an investigational fabrication system for transtibial prostheses. This fabrication method will be tested for comfort and function to determine feasibility of use for amputees in developing…
- Conditions
- Amputation, Amputation; Traumatic, Limb, Amputation, Traumatic
- Trial name
- NCT04725461
- Testing
- Low cost lower limb prosthetic socket
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
- Trial name
- NCT02991248
- Testing
- robotic training, spinal cord electrical stimulation, treadmill
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Shirley Ryan AbilityLab
Child Behavior
Neuromuscular Mechanisms of Specific Trunk Interventions in Children With CP
Determine the effect of repeated pelvis perturbation training on trunk posture and locomotor function in children with CP.
- Trial name
- NCT05805410
- Testing
- robotic hippotherapy, Conventional physical therapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Constraint Induced Movement Therapy for Walking in Individuals Post Stroke
To compare the effect of constraint induced movement therapy (CIMT) vs. treadmill training only on walking function in individuals post-stroke, a 6 week, single-blind, randomized training study will be conducted with three…
- Trial name
- NCT03264261
- Testing
- robotic training, treadmill training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia
Modulating Intensity and Dosage of Aphasia Scripts
The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia…
- Trial name
- MIDAS (NCT04138940)
- Testing
- Script Training
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Arm and Leg Cycling for Accelerated Recovery From SCI
The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in…
- Trial name
- NCT05619146
- Testing
- Motor-assisted arms and legs cycling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Incomplete Spinal Cord Injury
Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
The purpose of the project is to compare intensity (minutes in target heart rate zone) and steps per session across three gait training modalities, including body-weight supported treadmill training (BWSTT), overground gait…
- Trial name
- NCT06169657
- Testing
- Body-weight-supported treadmill training (BWSTT), EksoNR exoskeleton gait training, Overground gait training
- Where
- United States
- Sponsor
- Shirley Ryan AbilityLab