Clinical trials: sponsored by Icahn School of Medicine at Mount Sinai
Major Depressive Disorder, Depression
Cognitive Training for Mood and Anxiety Disorders
The purpose of this study is to investigate the effects of a computerized cognitive training program (an attention and memory exercise performed on a computer) on thinking and memory in individuals with mood and anxiety…
- Conditions
- Major Depressive Disorder, Depression, Bipolar Disorder, Post-traumatic Stress Disorder
- Trial name
- NCT02256566
- Testing
- emotional memory training exercise, memory training exercise
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Cognitive Training for Depression II
This study is evaluating the effects of two brain training exercises on: memory, cognitive processing and depression symptoms.
- Trial name
- NCT01934491
- Testing
- Cognitive Training A, Cognitive Training B
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mitral Valve Insufficiency, Coronary Artery Disease
Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation
Coronary artery bypass grafting (CABG) is a procedure that people with coronary artery disease (CAD) may undergo to increase blood flow to the heart.
- Trial name
- NCT00806988
- Testing
- Mitral Valve Repair, CABG
- Where
- 27 sites in United States, Canada and 1 more
- Volunteers
- 301 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Relapse Multiple Myeloma, Refractory Multiple Myeloma
Study of High Dose Carfilzomib in Multiple Myeloma Patients Who Have Progressed On Standard Dose Carfilzomib
The purpose of this study is to determine the safety and activity of the investigational drug known as carfilzomib in the treatment of multiple myeloma (MM) when it is given at doses above the usual dose after the standard dosing…
- Trial name
- NCT01775553
- Testing
- Carfilzomib
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ajai Chari
Spine Metastases
Minimally Invasive Surgery (MIS) for Spine Metastases
The purpose of this study is to collect information on the effect of minimally invasive spine tumor decompression on treated patients.
- Trial name
- NCT02367378
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Surrogate Decision Maker, After Death of Patient
The Surrogate Project (Surrogate Storytelling)
Research Protocol Abstract: This is a phase II controlled trial (RCT) of a "storytelling" intervention compared to no treatment among surrogates who have participated in a decision to limit life-sustaining treatment in the ICU…
- Trial name
- NCT01902784
- Testing
- Storytelling Interview
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Pittsburgh
External Cephalic Version
Study to Evaluate is ECV Success is Improved and the Side Effects Reduced With the Use of IV NTGL Versus Terbutaline
Breech presentation of a term pregnancy is a common occurrence. A procedure known as external cephalic version (ECV) is frequently used by obstetricians to turn the baby into the vertex position prior to delivery in order to…
- Trial name
- NCT02115256
- Testing
- Intravenous Terbutaline, Intravenous Nitroglycerine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yaakov Beilin
Induction of Labor
Foley Labor Induction Trial at Term and in PROM
This study is considering current standard oxytocin dosing regimen in combination with Foley bulb for cervical ripening is associated with improved outcomes including greater percentage of women delivered within or less than 24…
- Trial name
- NCT02098421
- Testing
- Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clopidogrel
Does Continued Use of Clopidogrel Into Surgery Cause Increased Perioperative Bleeding?
Patients who on taking clopidogrel are randomized to either continue clopidogrel into general surgery or discontinue clopidogrel 7 days before surgery. All patients resume clopidogrel after surgery.
- Trial name
- NCT01960296
- Testing
- Clopidogrel, Discontinue Clopidogrel
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Disease
Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy
The study will assess the regression of yellow plaque content of the lipid pool after aggressive lipid therapy by utilizing NIR spectroscopy.
- Trial name
- YELLOW (NCT01567826)
- Testing
- standard of care lipid therapy, Aggressive lipid therapy
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Annapoorna Kini
Multiple Sclerosis
Study to Evaluate Intravenous and Oral Steroids for Multiple Sclerosis Attacks
This clinical trial compares the relative efficacy of treating acute exacerbations of relapsing forms of Multiple Sclerosis with equivalent doses of oral and intravenous (IV) methylprednisolone.
- Trial name
- NCT00418145
- Testing
- megadose oral methylprednisolone, IV methylprednisolone
- Where
- 10 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fred Lublin
Bipolar Disorder
Treatment Study of Bipolar Depression
The purpose of this study is to determine whether a single intravenous administration of an N-methyl-D-aspartate antagonist is safe and effective for the acute treatment of bipolar depression.
- Trial name
- NCT00947791
- Testing
- ketamine, midazolam
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myelofibrosis
Study of Fludarabine Based Conditioning for Allogeneic Stem Cell Transplantation for Myelofibrosis
Stem cell transplantation is used to treat may types of diseases. There a 2 types of transplants, conventional (very intense) and reduced intensity-non-myeloablative, also called mini-transplants.
- Trial name
- NCT00572897
- Testing
- Fludarabine, Melphalan +/- ATG
- Where
- 12 sites in United States, Canada and 2 more
- Volunteers
- 66 people
- Sponsor
- John Mascarenhas
Prostate Cancer
Abiraterone Acetate Trial in African American Prostate Cancer Patients
This is a pilot study of abiraterone acetate in African American/Black patients with castration-resistant prostate cancer. The primary objective is to determine the correlation between germline polymorphisms and antitumor…
- Trial name
- NCT01735396
- Testing
- Abiraterone Acetate
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Neuroendocrine Tumors, Carcinoid Tumors
68Ga-Dotatoc Positron Emission Tomography (PET) for Somatostatin Receptor-Positive Neuroendocrine Tumors (NETs)
This study plans to demonstrate the safety and efficacy of [68Ga]-DOTA-tyr3-Octreotide ([68Ga]-DOTATOC) as an accurate imaging technique for diagnosis, staging, and monitoring of response to treatment in patients with…
- Trial name
- NCT02359500
- Testing
- 68Ga-DOTATOC PET
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Lale Kostakoglu
Gastric Cancer
Gastric In Vivo Study
The overall objective of this pilot study is to determine whether multispectral imaging increases the diagnostic accuracy of the current standard of high-definition white-light endoscopy for the detection of gastric neoplasia…
- Trial name
- NCT02207959
- Testing
- Proflavine Hemisulphate salt, White-light examination, Imaging with High Resolution Microendoscope
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Susana Gonzalez
Bipolar Disorder
Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder
This study will examine whether extended release galantamine, a drug approved by the Food and Drug Administration to reduce cognitive impairments in people with Alzheimer's disease, can perform the same function in stable people…
- Trial name
- NCT00741598
- Testing
- Galantamine-ER
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
HIV, Hepatitis C
Intervention to Improve HCV Treatment Uptake and Adherence in HIV/HCV Coinfection
End-stage liver disease, predominantly due to hepatitis C virus (HCV) infection, is one of the leading causes of death in person living with HIV infection.
- Conditions
- HIV, Hepatitis C, Co-Infection
- Trial name
- NCT02294136
- Testing
- Prep-C, Educational Control
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Actinic Keratoses
Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses
Sequential therapy with cryosurgery and ingenol mebutate may optimize the treatment of hypertrophic AKs and also treat non-hypertrophic AKs in this anatomic location.
- Trial name
- NCT02251652
- Testing
- Ingenol Mebutate, Cryotherapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pelvic Organ Prolapse
Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery
The purpose of this study is to determine the effectiveness of perineal pain control via injection of a local anesthetic to numb the pudendal nerve. The medication which is commonly used for this block is called marcaine.
- Trial name
- NCT02409498
- Testing
- pudendal block, no pudendal block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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