Clinical trials: sponsored by KU Leuven
Pregnant Women With Type 1 Diabetes
Risk for Ketonaemia in Type 1 Diabetes Pregnancies With Sensor-augmented Pump Therapy
The ROKSANA study is an open-label crossover RCT with the aim to evaluate whether sensor-augmented pump therapy (SAP) with predictive low glucose suspend technology is associated with an increased risk for ketonaemia during type…
- Trial name
- ROKSANA (NCT04292509)
- Testing
- SAP with stop before low, SAP with stop on low
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
PTSD, Stress, Psychological
The Efficacy of a Physical Activity Counselling Intervention on Mental Health in Firefighters
Objectives: The aim of this project will be to evaluate the efficacy of a lifestyle PA counselling program for physically inactive first responders with at least mild symptoms of either anxiety, depression or stress and their…
- Conditions
- PTSD, Stress, Psychological, Depressive Symptoms, Anxiety Disorders and Symptoms
- Trial name
- NCT05061225
- Testing
- Physical activity counselling
- Volunteers
- 60 people
- Sponsor
- KU Leuven
Bariatric Surgery Candidate
Impact of Bariatric Surgery on the Gut Environment
The purpose of this study is to investigate the impact of bariatric surgery on the gut health. Patients operated with Roux-en-Y gastric bypass or sleeve gastrectomy and obese patients who want too loose weight with a traditional…
- Trial name
- IMPORTUNE (NCT04345328)
- Where
- Belgium
- Volunteers
- 151 people
- Sponsor
- KU Leuven
Leadership, Identification
The 5R Shared Leadership Program in Older Adult Walking Groups
To test the efficacy of the 5R Shared Leadership program in older adults on participants' identification with their walking group, group cohesion, walking activity, and well-being, compared to a regular group walking program, the…
- Conditions
- Leadership, Identification, Empowerment
- Trial name
- NCT05038423
- Testing
- 5R Shared Leadership Program, 12-week structured walking program
- Where
- Belgium
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- KU Leuven
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Low Back Pain
Predictors of Work Resumption After Back Surgery
This prospective, longitudinal study aims to identify modifiable predictors of return to work after back surgery.
- Trial name
- WABS (NCT04747860)
- Where
- 9 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- KU Leuven
Social Behaviour, Brain Neoplasms
Social Cognition in Children Treated for a Brain Tumour
There is ample evidence that children treated for a brain tumour (BT) often develop deficits in social and emotional functioning. The investigators wish to examine the cause of these deficits, i.e.
- Conditions
- Social Behaviour, Brain Neoplasms, Cystic Fibrosis
- Trial name
- NCT01599052
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Appetitive Behavior
Food Structure of Pulses and Satiety
Diets containing (whole) pulses have been associated with the potential to increase satiety (and acute food intake). In vitro digestion studies of pulses have shown that (thermal) processing has the potential to modulate…
- Trial name
- NCT04922125
- Testing
- Pulse flour, Pre-processed pulse flour
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Exergame, Major Neurocognitive Disorder
Intervention Study of an Individualized Exergame Training for People With Major Neurocognitive Disorder
This study evaluates the feasibility of the intervention and the study design.
- Conditions
- Exergame, Major Neurocognitive Disorder, Long-term Care Facility, Nursing Home
- Trial name
- NCT04436315
- Testing
- Motor-cognitive training device, Active control condition
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Davy Vancampfort
Covid19
Long-term Effects of COVID-19: a Comparative Cohort Study
This study is a longitudinal cohort study which investigates the effect of COVID-19 in ambulatory care. This study aims to assess the effect of COVID-19 beyond the acute phase, i.e.
- Trial name
- CoCo (NCT05002205)
- Testing
- Questionnaires, spirometry, ECG
- Volunteers
- 180 people
- Sponsor
- KU Leuven
Multiple Sclerosis, Fatigue
Physiological Responses in Experimentally Induced Cognitive Fatigue in People With Multiple Sclerosis (MS)
The current study will add to the current knowledge by combining several electrophysiological techniques to examine the relationship between physiological responses and cognitive fatigue and daily activity performance in a…
- Conditions
- Multiple Sclerosis, Fatigue, Stress
- Trial name
- PREFIMS (NCT05003375)
- Testing
- High-challenging cognitive protocol to provoke stress and (cognitive) fatigue
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease, Freezing of Gait
The Effect of Split-belt Treadmill Training on Gait in Parkinson's Disease
People with Parkinson's disease (PD) often show gait impairments such as, shuffling gait, short steps and gait asymmetry and irregularity.
- Trial name
- NCT04176263
- Testing
- SBT, TBT
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 52 people
- Sponsor
- KU Leuven
Adverse Effects
Emergency Department Crowding in Relation to In-hospital Adverse Medical Events
Since the report "To Err is Human" by the Institute of Medicine (IOM) in 1999, attention was brought to the general public that adverse events in medicine are common and are one of the leading causes of morbidity and mortality…
- Trial name
- NCT01116323
- Where
- Belgium
- Volunteers
- 104,000 people
- Sponsor
- KU Leuven
Influenza With Pneumonia, Aspergillosis Invasive
Invasive Pulmonary Aspergillosis Complicating Influenza Infection
Study the incidence and outcome of invasive pulmonary aspergillosis (IPA) in ICU patients with severe influenza and in influenza-negative control patients with severe community-acquired pneumonia
- Trial name
- NCT03391492
- Where
- 2 sites in Belgium
- Volunteers
- 298 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Quality Improvement, Hip Fractures
Care Pathways for Benchmarking on Fragile Hip Fractures Rapid Recovery
The aim of this project is to build an international community of centers of excellence in the care for Fragile Hip Fracture Rapid Recovery patients.
- Trial name
- NCT03941353
- Testing
- Usual care
- Where
- Belgium
- Volunteers
- 298 people
- Sponsor
- European Pathway Association
Wheezing
Bronchodilators for Wheeze in Young Children Presenting to Primary Care: a Randomised, Placebo-controlled, Multicentre, Parallel Group Trial
Ten percent of infants are prescribed short-acting bronchodilators (i.e. salbutamol) for wheezing every year, yet evidence to support this treatment in children younger than two years old is scarce.
- Trial name
- KIWI (NCT04584034)
- Testing
- Salbutamol
- Sponsor
- UMC Utrecht
Operation Time, Complication of Surgical Procedure
CAS Versus Traditional Freehand Technique for Mandibular Reconstruction With Free Vascularized Fibular Flap
A total of 153 patients who underwent mandibular reconstruction by VFF were included from Jan 1999 to Dec 2019. The mandibular resection and reconstruction were performed by four experienced oral and maxillofacial surgeons.
- Trial name
- NCT04965441
- Testing
- Computer-assisted surgery
- Where
- Belgium
- Volunteers
- 153 people
- Sponsor
- KU Leuven
Head and Neck Cancer
Survival Analysis of Oral Cancer Patients
This study aims to assess the survival rate of oral squamous cell carcinoma (OSCC) patients following immediate mandibular reconstruction with vascularized fibula flap (VFF) and to identify risk factors influencing the overall…
- Trial name
- NCT04967638
- Testing
- tumor resection and mandible reconstruction
- Where
- Belgium
- Volunteers
- 74 people
- Sponsor
- KU Leuven
Ciliary Motility Disorders, Primary Ciliary Dyskinesia
Nasal Nitric Oxide Across Mutations in Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and…
- Trial name
- nNO_PCD (NCT04949308)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
Non-allergic Rhinitis
Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis
Chronic rhinitis is affecting more than 200 million people worldwide. Its prevalence is estimated to be as high as 30% of the Western population.
- Trial name
- NCT02288156
- Testing
- Capsaicin
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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