Clinical trials: sponsored by Massachusetts General Hospital
Substance Use Disorders, HIV/AIDS
Project Matter: Intervention to Improve HIV Self-care Among Men Who Have Sex With Men (MSM) With Substance Use Disorders
This study will implement a pilot randomized controlled trial (RCT, N=60) to assess the feasibility and acceptability a refined emotion regulation intervention designed to improve engagement in HIV-care among substance using HIV+…
- Conditions
- Substance Use Disorders, HIV/AIDS, Homosexuality, Male
- Trial name
- NCT03899220
- Testing
- Project Matter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Psychological Stress
Resiliency Program for Medical Interpreters
To develop and test a 4-session program to teach resiliency skills to Medical Interpreters.
- Trial name
- CARE (NCT02378597)
- Testing
- Behavioral: Resiliency Intervention
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation New Onset
A Pharmaco-surgical Approach to Reduce Postoperative Atrial Fibrillation After Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery with an estimated incidence around 35%.
- Trial name
- NCT05780320
- Testing
- Prophylactic amiodarone and posterior pericardiotomy
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital
HPV Positive Oropharyngeal Squamous Cell Carcinoma
ctDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca)
The purpose of this study is to test a new liquid biopsy assay for detecting residual disease after surgery in patients with HPV-associated head and neck cancer.
- Trial name
- Clear-HPVca (NCT06730412)
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Colorectal Cancer
ASPirin Intervention for the REDuction of Colorectal Cancer Risk
This research study is investigating the use of aspirin as a potential chemopreventive agent to reduce risk of colorectal cancer
- Trial name
- ASPIRED (NCT02394769)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Perinatal Depression, Perinatal Anxiety
Prospective Study Evaluating a Novel Mobile App Based Preventive Behavioral Intervention for Perinatal Mood Disorders
The primary aim of the study is to investigate whether a novel mobile App-based behavioral intervention in pregnant women can: (1) prevent and/or decrease the incidence of perinatal mood disorders (2) decrease the severity and/or…
- Trial name
- NCT04914299
- Testing
- App-based "positive intelligence" intervention, Standard of care
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Endothelial Dysfunction, Hemolysis Intravascular
Effects of Nitric Oxide on the Endothelium During Hemolysis.
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899.
- Conditions
- Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- NCT03748082
- Testing
- Nitric Oxide, Reactive Hyperemia Index, Endothelial Cells Collection
- Where
- 2 sites in United States
- Sponsor
- Massachusetts General Hospital
PTSD, Cardiovascular Disease
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel)…
- Conditions
- PTSD, Cardiovascular Disease, Cardiovascular Disease Risk Factors
- Trial name
- NCT07260032
- Testing
- Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Oxidative Stress
Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899.
- Conditions
- Cardiovascular Diseases, Oxidative Stress, Endothelial Dysfunction
- Trial name
- NCT04022161
- Testing
- Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide
- Where
- 2 sites in United States, United Kingdom
- Sponsor
- Massachusetts General Hospital
Pneumonia, Aspiration
Validation of Aspiration Markers in Intubated Patients
The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube [ETT] cuff leakage) in mechanically ventilated, critically ill patients.
- Trial name
- NCT02598713
- Testing
- Aspiration Marker
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Morbid Obesity, Respiratory Failure
Comparison of Esophageal Manometry and CT Scan Measurements
The goal of this study is to determine the relationship between esophageal pressure (Pes) and superimposed pressure (SP) in subjects with morbid obesity.
- Trial name
- NCT04213911
- Testing
- low-dose chest CT scan, insertion of esophageal balloon
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Subjects
Methemoglobin Concentration in High Dose Inhaled Nitric Oxide
The goal of this clinical trial is to learn about the kinetic of methemoglobin in healthy subjects breathing high dose inhaled nitric oxide.
- Trial name
- NCT05612074
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Laryngeal Dystonia, Spasmodic Dysphonia
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
- Trial name
- NCT05150093
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Anarthria, Dysarthria
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to…
- Conditions
- Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Speech-02 (NCT06094205)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Quality of Life
Nurse-Led Quality of Life Study-Phase I
The purpose of this study is to pilot test a brief, population-specific nurse-led, quality of life (QOL) intervention with early phase cancer clinical trial (EP-CT) participants.
- Trial name
- NCT05853614
- Testing
- Quality of Life Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Lung Neoplasms, Esophageal Lesion
Near-Infrared Perfusion During Minimally Invasive Thoracic Surgery Download
This will be a prospective, (NSR), single-center feasibility study of the Olympus VE2 NIR Imaging System to assess perfusion using NIR during minimally invasive esophagectomy and pulmonary segmentectomy.
- Trial name
- NCT05346380
- Testing
- Olympus VE2 NIR Imaging System, Indocyanine green
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Adolescent Drinking, Adolescent Substance Use
Optimizing and Advancing SBIRT in Schools
The goal of this clinical trial is to establish whether brief interventions for alcohol use can be delivered in schools for both indicated prevention and selected prevention, determine if an expanded workforce is an effective…
- Conditions
- Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
- Trial name
- OASIS (NCT06206161)
- Testing
- Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
- Where
- United States
- Volunteers
- 21,000 people
- Sponsor
- Massachusetts General Hospital
Port-Wine Stain
Tolerability of 532 nm Laser Treatment of Port Wine Stains
The goal of this study is to learn about treatment of port wine birthmarks treated with an FDA-approved 532 nm laser. The main questions it aims to answer are: How well are the treatments tolerated? Are there differences in…
- Trial name
- NCT05841628
- Testing
- 532 nm laser treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
The primary objective of this study is to evaluate the safety and efficacy of CNTX-6970 for the treatment of pain related to OA of the knee compared to placebo.
- Trial name
- NCT05025787
- Testing
- CNTX-6970
- Where
- 16 sites in United States
- Volunteers
- 55 people
- Sponsor
- Maurizio Fava, MD
Multiple Myeloma, Waldenstrom Macroglobulinemia
Covid-19 Vaccine Responsiveness in MM and Waldenstrom
This research is being done to see if the immune (defense) system of people with Multiple Myeloma and Waldenstrom's Macroglobulinemia reacts to the COVID-19 vaccine.
- Conditions
- Multiple Myeloma, Waldenstrom Macroglobulinemia, Immune System Disorder, Covid19
- Trial name
- NCT04830046
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Massachusetts General Hospital
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