Clinical trials: sponsored by University of Florida
Fibromyalgia, Pain
Spinal and Supra-Spinal Pain Mechanisms in Patients With Fibromyalgia
Fibromyalgia (FM) patients have increased windup (WU). However, WU of FM patients is only quantitatively but not qualitatively different from healthy controls (HC).
- Trial name
- NCT03464292
- Testing
- Capsaicin Patch 8% or 0.1% Capsaicin Cream, Vehicle Patch
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pelvic Organ Prolapse, Stress Urinary Incontinence
Lidocaine for Pessary Check Pain Reduction
The primary objective of this study is to estimate the effect of lidocaine jelly on patient pain at the time of office pessary removal.
- Trial name
- NCT05493735
- Testing
- Lidocaine Hcl 2% Jelly
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Sickle Cell Disease
iCanCope With Sickle Cell Pain
The project will test a tailored web and smartphone-based application (iCanCope with SCD) to improve pain self-management and functioning in youth (aged 12-18) with sickle cell disease.
- Trial name
- NCT03201874
- Testing
- Pain self-management, Education
- Where
- 4 sites in United States, Canada
- Volunteers
- 137 people
- Sponsor
- Seattle Children's Hospital
Pneumonia
BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia
The study plans to randomize a total of 240 patients infected with Gram-negative bacterial pneumonia to receive beta-lactam (meropenem, cefepime, or piperacillin/tazobactam) continuous or intermittent infusion and collect…
- Trial name
- NCT05102162
- Testing
- Cefepime, Meropenem, or Piperacillin/Tazobactam
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Other and Unspecified Complications of Amputation Stump
Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis
The purpose of this study is to determine if transfemoral amputees of varied etiology will demonstrate increased function, safety and quality of life following accommodation with a new knee prosthesis as compared to their former…
- Trial name
- NCT01473992
- Testing
- Otto Bock C-Leg, Otto Bock Genium
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jason Highsmith
Anxiety, Type 1 Diabetes
Mindfulness Training in Adolescents With Type 1 Diabetes
Creation of an adaptation of a mindfulness-based stress reduction mobile health application specifically designed for adolescents living with Type 1 diabetes.
- Conditions
- Anxiety, Type 1 Diabetes, Quality of Life
- Trial name
- NCT06140030
- Testing
- Mindfulness training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Covid19
Swallowing Impairment After COVID-19 Infection
This is an observational study, in which people recovering from COVID-19 infection will attend an outpatient clinic for a comprehensive swallowing assessment.
- Trial name
- NCT04537650
- Testing
- Videofluoroscopic Swallowing Study (VFSS)
- Where
- 2 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Alcohol Use Disorder (AUD), Subjective Response to Alcohol (SR)
Impulsivity and Alcohol Response
Impulsivity, a well-known risk factor predicting negative outcomes, refers broadly to a proclivity towards rapid action with a suboptimal regard for future consequences.
- Trial name
- IDEA (NCT03736343)
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Florida
Poor Quality Sleep
Sleep Well for Healthy Brain
The purpose of this study is to slow down the aging of the participant's brain by improving sleep quality.
- Trial name
- NCT04583033
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty Biomechanics
In total knee arthroplasty (TKA), the relationship between implant design, soft tissue balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction and functional outcomes is highly complex and…
- Trial name
- NCT03671954
- Testing
- Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments
- Where
- 4 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Florida
Non-specific Low Back Pain
Gamified Rehab vs Take-home Packet Rehab for Non-specific Low Back Pain
Two groups with non-specific low back pain will be completing the same exercise protocol. The leaderboard group will have a gamified experience and the take-home packet group will be using a paper take-home packet.
- Trial name
- NCT05573932
- Testing
- Leaderboard, Take-home packet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Central Florida
Obesity in Childhood
The Baby Act Trial (BAT): a Multimodal Lifestyle Intervention
Childhood obesity is increasing, particularly among Hispanics. Rapid weight gain during childhood increases the risk of obesity in childhood and in adulthood, also increasing the risk of chronic diseases such as diabetes and…
- Trial name
- BAT (NCT03517891)
- Testing
- WIC+
- Where
- Puerto Rico
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Post Traumatic Stress Disorder
Written Exposure Therapy to Improve Lives After Stress Exposure
The main objective of this study is to determine whether remote delivery of written exposure therapy after motor vehicle collision reduces incidence and severity of posttraumatic stress symptoms in high risk individuals.
- Trial name
- WISE (NCT05390775)
- Testing
- Written Exposure Therapy (WISE), Non-emotional Writing
- Where
- 6 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Spinal Cord Injuries
Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury
This study will examine if acute intermittent hypoxia (brief episodes of breathing lower oxygen), which has been shown to enhance plasticity and motor output, can enhance functional outcomes and muscle activation in individuals…
- Trial name
- NCT03071393
- Testing
- Hypoxia via Hypoxico Hyp-123
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Urethral Stricture
Clostridium Histolyticum Collagenase Injection for Urethral Disease
The purpose of this study is to assess the efficacy of clostridium histolyticum collagenase (XIAFLEX®) in treating urethral strictures.
- Trial name
- NCT02948842
- Testing
- Clostridium Histolyticum Collagenase, Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of South Florida
HIV Infections, Methamphetamine-dependence
Stimulant Use and Methylation in HIV
This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.
- Conditions
- HIV Infections, Methamphetamine-dependence, Methamphetamine Abuse
- Trial name
- NCT05916989
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Florida International University
Smoking, Tobacco, Tobacco-Related Carcinoma
The Lung Screening, Tobacco and Health Project
The purpose of this study is to compare intensive telephone counseling (ITC) plus the nicotine patch vs. standard telephone counseling plus the nicotine patch (Usual Care; UC) among current smokers undergoing lung cancer…
- Conditions
- Smoking, Tobacco, Tobacco-Related Carcinoma, Tobacco Use, Lung Cancer Screening
- Trial name
- NCT03200236
- Testing
- Intensive Telephone Counseling (8 sessions) with nicotine replacement, Usual Care: Telephone counseling (3 sessions) with nicotine replacement
- Where
- 7 sites in United States
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Osteoporosis, Osteopenia or Osteoporosis
Assessment of Cortical Bone Mechanics Technology (CBMT) Fracture Discrimination Capability
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility (i.e., weakness) and an increased risk for fracture.
- Conditions
- Osteoporosis, Osteopenia or Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Risk
- Trial name
- STRONGER (NCT05721898)
- Testing
- Cortical Bone Mechanics Technology
- Where
- 5 sites in United States
- Volunteers
- 394 people
- Sponsor
- Ohio University
Autologous Haemopoietic Stem Cell Transplant
Beta-glucan and Fatigue in HSCT Survivors
This is a single-center, randomized, double-blind, placebo-controlled study exploring the effects of a yeast-derived β-glucan on clinically significant fatigue among survivors of autologous HCT due to multiple myeloma.
- Trial name
- NCT05524688
- Testing
- Beta-glucan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Mild Cognitive Impairment
Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and…
- Trial name
- TVNS MCI (NCT03359902)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Florida
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