Clinical trials: sponsored by University of Minnesota
Alzheimer's Disease
Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability
Patients with Alzheimer's disease (AD) can have seizures in addition to losing their memory and other mental functions (referred to as cognitive functions).
- Trial name
- LEV-AD (NCT02002819)
- Testing
- levetiracetam
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Hypothalamic Obesity
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
The proposed multicenter study will test the effect of glucagon-like peptide (GLP)-1 agonist exenatide once weekly extended-release (ExQW, Bydureon®) on clinical outcomes and metabolic parameters in a double-blind…
- Trial name
- ECHO (NCT02664441)
- Testing
- Exenatide
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Seattle Children's Hospital
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Not Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients randomized 1:1 to daily losartan or placebo for 10 days or treatment failure (hospital admission).
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04311177
- Testing
- Losartan
- Where
- 4 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Minnesota
Small Intestine Bacteria
Small Bowel Microbiota Characterization in Healthy Individuals Before and After Consumption of a Western Diet
Does the small bowel microbiota in healthy individuals change after consumption of a Western diet?
- Trial name
- Microbiota (NCT03266536)
- Testing
- Western diet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Pain
Liposome Bupivacaine Interscalene Total Shoulder
This is a randomized prospective outcomes study comparing two groups of patients. One group will receive liposomal bupivacaine plus bupivacaine and the other will receive bupivacaine alone in interscalene blocks when undergoing…
- Trial name
- NCT03587636
- Testing
- liposome bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypoplastic Left Heart Syndrome
Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
This is a Phase I study to determine the safety and feasibility of injections of autologous umbilical cord blood (UCB) cells into the right ventricle of Hypoplastic Left Heart Syndrome (HLHS) children undergoing a scheduled Glenn…
- Trial name
- NCT01883076
- Testing
- autologous cell-based delivery
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Timothy J Nelson, MD, PhD
Smoking, Tobacco Use
COMET2 Project 1 Filter Ventilation Study
Phase III randomized, 2 x 2 design, open label, multi-center study that will assess the removal of filter ventilation on smoking behavior and biomarkers in a tobacco and nicotine product marketplace simulation of a real world…
- Trial name
- NCT03637972
- Testing
- Ventilated cigarettes only, Unventilated cigarettes only, Access to Experimental Marketplace: Ventilated cigarettes + alternative nicotine delivery systems
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Tobacco Use Disorder
Novel Medication as a Potential Smoking Cessation Aid
The purpose of this study is to provide preliminary information assessing if levomilnacipran may be effective at increasing smoking cessation rates.
- Trial name
- NCT02265367
- Testing
- Levomilnacipran
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Minnesota
Dementia, Memory Loss
Social Support Aid For People With Dementia
The goal of this study is to determine the acceptability, utility, and preliminary effectiveness of a facial recognition technology for persons with memory concerns and their family care partners.
- Trial name
- NCT03645694
- Testing
- Social Support Aid
- Volunteers
- 48 people
- Sponsor
- University of Minnesota
Motivational Interviewing, BMI, OHI
Brief Motivational Interviewing (BMI)
The goal of this research study is to determine if the utilization of brief motivational interviewing (BMI) during continuous care is superior compared to traditional oral hygiene instruction (OHI) to reduce patients' plaque…
- Trial name
- NCT03571958
- Testing
- BMI
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
HPV-associated Cancer
Multi-Level Communication Strategies for HPV Vaccination in Hmong Adolescents
The specific aims are: 1) to design a multilevel, theory-driven, highly interactive, culturally and cognitively tailored hAppy app intervention to facilitate HPV vaccination completion among Hmong adolescents and their parents…
- Trial name
- NCT04017143
- Testing
- HPV app intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pregnancy Complications, Birth Injuries
SMS Maama Project COVID-19
The study's purpose is to demonstrate the ability of an mHealth platform as a feasible way of sharing information in a time of restricted movement in order to inform future studies.
- Trial name
- NCT04739462
- Testing
- mHealth Platform
- Where
- 2 sites in United States, Uganda
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Transplantation Infection, Epstein-Barr Virus Infections
ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation
Our study will compare all kidney transplant recipients receiving valganciclovir vs. valacyclovir for one year following kidney transplant and compare: 1.
- Conditions
- Transplantation Infection, Epstein-Barr Virus Infections, Cytomegalovirus Infections
- Trial name
- NCT01972035
- Testing
- Valacyclovir, Valganciclovir
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia
Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy
This is a prospective, observational study to establish the connection between periodontitis and BSI in AML patients planning to receive intensive chemotherapy.
- Trial name
- NCT04858594
- Testing
- Planned Chemotherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Healthy
YouTube-Delivered Physical Activity Intervention
This study will be an 8-week randomized controlled trial examining the effects of a YouTube-delivered aerobic and muscle strengthening physical activity intervention on university students' physical activity, fitness, sleep…
- Trial name
- NCT04499547
- Testing
- YouTube-delivered aerobic and muscle-strengthening physical activity intervention
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
COVID-19
Study of FT516 for the Treatment of COVID-19 in Hospitalized Patients With Hypoxia
This is a Phase I study with the primary objective of identifying the maximum tolerated dose (MTD) of FT516 using 3 dose-escalation strategies (number of doses and cell dose) for the treatment of coronavirus disease 2019…
- Trial name
- NCT04363346
- Testing
- FT516
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Lateral Elbow Tendinopathy, Elbow Pain
Isometric Intervention for Lateral Elbow Tendinopathy
This study will be looking at people with lateral elbow tendinopathy (elbow pain). The goal is to determine if a one-time isometric intervention will positively change the level of pain and strength as compared to baseline…
- Conditions
- Lateral Elbow Tendinopathy, Elbow Pain, Elbows Tendonitis, Elbow Sprain
- Trial name
- NCT03756155
- Testing
- isometric intervention
- Where
- United States
- Sponsor
- University of Minnesota
COVID, COVID-19
Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)
This protocol will serve as a platform for assessing treatments for adult patients hospitalized for medical management of COVID-19 without related serious end-organ failure.
- Conditions
- COVID, COVID-19, SARS-CoV-2, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- NCT04546581
- Testing
- Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG), Remdesivir
- Where
- 39 sites in United States, Denmark and 5 more
- Volunteers
- 593 people
- Sponsor
- University of Minnesota
Allogeneic HCT Survivors
Improving Self-Efficacy, Resolving Inflammaging Allo HSCT Survivors in Personal Training
This protocol is a pilot study of a personalized and supervised 10-week strength training program to improve self-efficacy and resolve biomarkers of inflammaging in a cohort of allogeneic hematopoietic transplant (HCT) long-term…
- Trial name
- NCT03609203
- Testing
- 10 Weeks of Strength Trailing, Group Nutrition Discussion: week 1, week 5 and week 10
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Quality of Life, Anxiety
CBT and Quality of Life of People With HIV, COVID-19 and Anxiety or Depression
Experimental open-label randomized clinical trial to determine the effect of virtual Cognitive Behavioral Therapy (CBT) on the quality of life of patients with HIV, COVID-19 and anxiety or depression.
- Conditions
- Quality of Life, Anxiety, Depression
- Trial name
- COVIHMENT-19 (NCT05185921)
- Testing
- Trial-based Cognitive therapy
- Where
- Peru
- Volunteers
- 182 people
- Sponsor
- Universidad Peruana Cayetano Heredia
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