Clinical trials: sponsored by Case Comprehensive Cancer Center
Malignant Neoplasm of Prostate, Locally Advanced Prostate Cancer
STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer
The goal of this clinical trial is to is to investigate if it is possible to lower the chance of cancer reoccurrence and also preserve quality of life by using the drug Pluvicto instead of androgen-deprivation therapy to the…
- Trial name
- STARLiT (NCT06574880)
- Testing
- Lu-PSMA-617, 5-fraction Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Angela Y. Jia, MD PhD
Myelodysplastic Syndromes, MDS/MPN Crossover Syndromes
5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
Another term for myelodysplastic syndrome is bone marrow failure. The bone marrow is where components of blood such as red cells, platelets and white cells are made.
- Trial name
- NCT04187703
- Testing
- 5-azacytidine, Decitabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Benjamin Tomlinson
Multiple Myeloma, Multiple Myeloma in Relapse
UF-KURE-BCMA CAR-T Cells in Patients With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to determine if UF-KURE-BCMA (B-Cell Maturation Antigen) chimeric antigen receptor T cells (CAR-T cells) can be used to treat relapsed or treatment refractory multiple myeloma (RRMM).
- Conditions
- Multiple Myeloma, Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
- Trial name
- NCT06698744
- Testing
- UF-KURE-BCMA CAR T-cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Sponsor
- David Wald
Small-cell Lung Cancer, Large Cell Neuroendocrine Carcinoma of the Lung
Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC
The purpose of this study is to: Test how well the study medicine Abemaciclib, a CDK4/6 inhibitor, works to shrink lung cancer tumors in the body.
- Conditions
- Small-cell Lung Cancer, Large Cell Neuroendocrine Carcinoma of the Lung, Extrapulmonary Small Cell Carcinoma
- Trial name
- NCT04010357
- Testing
- Abemaciclib,
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
Liver Cancer, Hepatocellular Carcinoma
68Ga-PSMA-11 PET-directed Radioligand Therapy in Metastatic Hepatocellular Carcinoma (HCC)
The purpose of this study is to look at the effects (good and bad) of a drug called 177Lu-PSMA-617 (also known as the study drug) when given to participants who have prostate specific membrane antigen (PSMA) positive liver cancer.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Metastatic Liver Cancer
- Trial name
- NCT06852820
- Testing
- Lu-PSMA-617
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Melissa Lumish
Hepatocellular Carcinoma, Liver Cancer
Maintenance Zanzalintinib and Durvalumab in Participants With Advanced Hepatocellular Cancer
This research study is for people who were treated with tremelimumab and durvalumab for advanced liver cancer and who are currently receiving durvalumab. Participants in this study will receive a drug called zanzalintinib.
- Trial name
- NCT07226063
- Testing
- Durvalumab, Zanzalintinib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Amit Mahipal
Cutaneous Malignant Melanoma, Renal Cell Cancer
Low-Dose-Rate Brachytherapy Combined With Immune Checkpoint Inhibition in Cancer
This is a pilot study of combination low dose rate brachytherapy (LDR) added to standard of care (SOC) immunotherapy in stage III and IV melanoma, stage IV renal call cancer, and stage IV urothelial cancer.
- Conditions
- Cutaneous Malignant Melanoma, Renal Cell Cancer, Urothelial Cancer of Renal Pelvis
- Trial name
- NCT04620603
- Testing
- Low Dose Rate Brachytherapy (LDR), Standard-of-Care Immunotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Non Hodgkin Lymphoma
Evaluate the Safety of UF-KURE19 Cells in Non-Hodgkin Lymphomas
This study seeks to determine the safety and efficacy of the infusion of autologous CD19 CAR-T cells that are manufactured using an ultra-fast process.
- Trial name
- NCT05400109
- Testing
- UF-KURE19 CAR-T cells, Fludarabine, Cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- David Wald
Prostate Cancer
Improving Patient Understanding of Their Prostate Cancer Diagnosis Using AI
The purpose of this study is to determine if ChatGPT (an artificial intelligence driven chatbot) can help patients better understand their own pathology results and prostate cancer diagnosis.
- Trial name
- NCT07040501
- Testing
- Chat GPT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
The purpose of this study is to identify interventions that are designed to better serve women who are homeless, with a specific focus on increasing screening rates and decreasing late stage breast cancer diagnosis among this…
- Trial name
- NCT04348123
- Testing
- Survey, Education Session
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Case Comprehensive Cancer Center
Malignant Neoplasm, Cancer
Decreasing Chemotherapy Induced Distress Using Immersive Virtual Reality in Patients With Cancer
The goal of this clinical trial is to learn if the use of virtual reality during chemotherapy treatment helps participants achieve an improvement in distress, which may include unpleasant experience, anxiety, depression and/or…
- Trial name
- NCT06446115
- Testing
- Virtual Reality, Preferred activity, Questionnaires
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Robotic Telesurgery in Urology
The goal of this clinical trial is to confirm the safety and feasibility of robotic telesurgery when used for the surgical management of prostate cancer in participates undergoing treatment for prostate cancer.
- Trial name
- NCT07541066
- Testing
- High-Intensity Focused Ultrasound (HIFU) robotic device
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Treatment With Proton Beam Radiation Therapy
Proton Therapy Patient Registry
The purpose of this study is to establish a database (or "registry") of patients treated with proton beam therapy at the University Hospitals (UH) Proton Therapy Center.
- Trial name
- NCT02986048
- Testing
- Proton Beam Therapy
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Case Comprehensive Cancer Center
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors
The purpose of this research study is to determine whether testing of stool for a panel of markers will enable us to detect polyps and cancer compared to standard testing.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Stage I Colorectal Cancer, Stage II Colorectal Cancer
- Trial name
- NCT04624555
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Cleveland African American Prostate Cancer Project
The purpose of this research is to test intervention strategies that encourage and support Black or African American men who are 40 and older to complete prostate cancer screening, and specifically to complete a prostate-specific…
- Trial name
- NCT05469269
- Testing
- Passive Education, Education by Community Navigator, Education at Community Outreach Screening Event
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Effectiveness of AI Genetic Counseling Program vs In-person Genetic Counseling in Breast Cancer
The purpose of this study is to help better understand the uptake and impact of genetic testing for women diagnosed with breast cancer who do not meet National Comprehensive Cancer Network (NCCN) criteria for genetic testing.
- Trial name
- NCT04354675
- Testing
- Automated program (ChatBot), Genetics counselor, BCGCKQ Survey
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Cancer Patients
The purpose of this study is to learn whether an education and support program can help caregivers feel more confident in technical and communication skills needed to care for a person with cancer.
- Trial name
- NCT04055948
- Testing
- One-on-one support/educational sessions, Telephone booster contact
- Where
- 2 sites in United States
- Volunteers
- 484 people
- Sponsor
- Case Comprehensive Cancer Center
Somatic Mutation
Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
The goal of this study is to This research team is conducting this study to develop methods to measure the biological impact of exposure to the chemicals released following the February 3, 2023 train derailment on residents of…
- Trial name
- NCT06357845
- Testing
- Survey, Biological specimen collection, Communications about study updates and future research opportunities
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Barrett's Esophagus
Detection of Barrett s Esophagus in Patients Without GERD Symptoms
The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.
- Trial name
- NCT04880044
- Testing
- EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Case Comprehensive Cancer Center
Skin Cancer, Skin Carcinoma
Effects of Lavender Aromatherapy on Patient Anxiety During Mohs Micrographic Surgery
This study aims to improve patient comfort by exploring the potential of lavender aromatherapy in reducing anxiety and unpleasant odor perception during Mohs Micrographic Surgery (MMS).
- Trial name
- NCT06167096
- Testing
- Lavender essential oil, Water
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Case Comprehensive Cancer Center