Clinical trials: sponsored by University of Alabama at Birmingham
Spinal Cord Injuries, Multiple Sclerosis
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
The UAB Institute for Arts In Medicine (AIM) is currently implementing an expressive emotional writing pilot project for adults with paralysis caused by neurological conditions such as traumatic head or spinal cord injury.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Transverse Myelitis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT04721717
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Older Adults
Making Intergenerational Connections Through Arts
The purpose of the study is to evaluate the impact on older adults' wellbeing of participating in a 10-week conversation about arts and culture with an international university student whose native language is not English.
- Trial name
- NCT05986149
- Testing
- Conversation about arts and culture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Breast Neoplasm
Improved Successful Retrieval Rate of HydroMARK Plus Breast Biopsy Site Marker in Comparison to HydroMARK as Well as Improved Surgeon Satisfaction
The purpose of the study is to test how successful the retrieval rate of the new HydroMARK Plus Breast Biopsy Site Marker in comparison to HydroMARK.
- Trial name
- NCT06294574
- Testing
- HydroMARK Plus Clip
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Hemianopia, Homonymous
Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia
This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training.
- Trial name
- NCT06638619
- Testing
- Biofeedback Fixation Training, Saccadic Reading Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
The goal of this clinical trial is to learn if the time an individual eats each day impacts neurological health in people with multiple sclerosis. The main questions the investigators are asking are: 1.
- Trial name
- Meal Time MS (NCT07475377)
- Testing
- Time Restricted Eating, Unrestricted eating
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Acellular Dermal Matrix, Alveolar Mucosa
Assessment of Two Soft Tissue Augmentation Using Acellular Dermis Around Dental Implants
This study aims to compare soft tissue grafting with acellular dermis at Phase I or Phase II dental implant surgery.
- Trial name
- NCT07512245
- Testing
- Phase I dental implant placement with acellular dermis, Phase II dental implant uncovery with acellular dermis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Dental Implant
To Compare the Two Implant Placement Protocols to Evaluate Placement Accuracy and Post-operative Healing of the Implant
The goal of this study is to evaluate two commonly utilized surgical guide protocols to determine dental implant placement accuracy compared to pre-operative computerized planning, post-operative healing and bone levels to…
- Trial name
- NCT07512258
- Testing
- Pilot Drill Guide (PDG), Fully Guided (FG)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer (H&N)
Evaluating Avive+ Soft Tissue Matrix for Prevention of Superficial Radial Nerve Morbidity Following Radial Forearm Free Flap Harvest
Radial forearm free flap (RFFF) reconstruction is commonly used for head and neck defects but is associated with donor-site morbidity, including neuropathic pain and sensory disturbance.
- Trial name
- NCT07558096
- Testing
- Standard Closure (Control), Avive+ Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Rheumatoid Arthritis
RA-PRO PRAGMATIC TRIAL
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab…
- Trial name
- RA-PROPR (NCT04692493)
- Testing
- targeted synthetic DMARD class, non-TNFi-biologic class
- Where
- 49 sites in United States, Canada
- Volunteers
- 924 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.
- Trial name
- NCT05482126
- Testing
- Intraoperative Behavioral Testing, Behavioral Testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
The purpose of the study is to see that in addition to existing therapy, how well an additional procedure named spinal cord stimulation might reduce blood vessel spasm from aneurysm rupture.
- Trial name
- NCT06443177
- Testing
- Vectris trial leads and stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Abdominal Abscess
Abdominal aBscess Catheter Sclerotherapy (ABCS)
This is a single center, two arm phase I/II clinical trial exploring the use of chemical sclerosants (ethanol and povidone iodine) in decreasing the time needed for catheter drainage for patients with non-fistulous intraabdominal…
- Trial name
- ABCS (NCT06906029)
- Testing
- Catheter Sclerotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Extreme Prematurity, Enteral Nutrition
High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants
This Phase II, parallel-group, masked, randomized clinical trial aims to evaluate whether a DHA/ARA-enriched, fortified human milk diet administered during the first 14 days of life reduces respiratory morbidity and improves lung…
- Conditions
- Extreme Prematurity, Enteral Nutrition, Bronchopulmonary Dysplasia
- Trial name
- MEND-BPD (NCT07307612)
- Testing
- High-energy group, Standard-energy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Pancreatitis, Acute
Safety and Tolerability of Pirfenidone in Acute Pancreatitis
The goal of the current pilot clinical trial is to evaluate the safety and tolerability of pirfenidone in patients with predicted moderately severe and severe acute pancreatitis.
- Trial name
- NCT05350371
- Testing
- Pirfenidone Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Protein and Resistance Exercise to Stop Sarcopenic Obesity Now
The purpose of this study is to examine the separate and combined effects of a high-protein (HP) diet and resistance training (RT) on body composition and potential biological moderators of body weight in women and men >50y.
- Trial name
- PRESS ON (NCT04014296)
- Testing
- High Protein Diet Counseling, Resistance Training Counseling, Intensify Initial Intervention
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Low Vision, Both Eyes
Virtual Reality-Base Intelligent Orientation and Mobility Specialists Trial
The human subject research is a randomized, controlled training trial that tests the effectiveness of three Virtual Reality-based Intelligent Orientation and Mobility Specialists (VR-IOMSs) in teaching orientation and mobility…
- Trial name
- VR-IOMS (NCT04639531)
- Testing
- Orientation and Mobility Training with VR-IOMSs, Orientation and Mobility Training with COMS, No Orientation and Mobility Training
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Alabama at Birmingham
Multiple Myeloma
Sequential Therapy in Multiple Myeloma Guided by MRD Assessments
This research study will determine the proportion of patients with lowest minimal residual disease (MRD) response obtainable after receiving 6 cycles of study treatment.
- Trial name
- MASTER-2 (NCT05231629)
- Testing
- Dara-VRd intensification, Dara-R maintenance, AHCT intensification, Dara-R maintenance, AHCT intensification, Tec-Dara consolidation, Tec-Dara maintenance
- Where
- 10 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2
Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)
Brief Summary: The FREEDOM study aims to develop a scalable intervention to improve type 2 diabetes mellitus control in low-income Black adults in the Deep South.
- Trial name
- FREEDOM (NCT05288452)
- Testing
- Digital Health Coaching, Food Box Delivery, Remote Patient Monitoring (RPM)
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Alabama at Birmingham
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Chronic Illness, Heart Failure - NYHA II - IV
An Optimization Pilot to Optimize An Early Palliative Care Intervention for Advanced Heart Failure
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this randomized factorial pilot trial is to identify feasibility, acceptability, and preliminary efficacy of components of an…
- Trial name
- UPHOLDS (NCT05879887)
- Testing
- UPHOLDS (Utilizing Palliative Care for Heart Failure Optimized using Lay Navigators to Decrease Suffering)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham